Genetic epidemiological studies suggest that individual variation in susceptibility to schizophrenia is largely genetic, reflecting alleles of moderate to small effect in multiple genes. Molecular genetic studies have identified a number of potential regions of linkage and 2 associated chromosomal abnormalities, and accumulating evidence favors several positional candidate genes. These findings are grounds for optimism that insight into genetic factors associated with schizophrenia will help further our understanding of this disease and contribute to the development of new ways to treat it.
George Kirov, Michael C. O’Donovan, Michael J. Owen
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Shared and distinct alterations of white matter tracts in remitted and nonremitted patients with schizophrenia.
Huang JY, Liu CM, Hwang TJ, Chen YJ, Hsu YC, Hwu HG, Lin YT, Hsieh MH, Liu CC, Chien YL, Tseng WI |
Human Brain Mapping | 2018 |