Genetic epidemiological studies suggest that individual variation in susceptibility to schizophrenia is largely genetic, reflecting alleles of moderate to small effect in multiple genes. Molecular genetic studies have identified a number of potential regions of linkage and 2 associated chromosomal abnormalities, and accumulating evidence favors several positional candidate genes. These findings are grounds for optimism that insight into genetic factors associated with schizophrenia will help further our understanding of this disease and contribute to the development of new ways to treat it.
George Kirov, Michael C. O’Donovan, Michael J. Owen
Title and authors | Publication | Year |
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Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
Accept or refuse? A pilot study of patients' perspective on participating as imaginary research subjects in schizophrenia.
Kim JH, Kim D, Park SH, Nam J |
Psychiatry investigation | 2009 |
Whole genome association study in a homogenous population in Shandong peninsula of China reveals JARID2 as a susceptibility gene for schizophrenia.
Liu Y, Chen G, Norton N, Liu W, Zhu H, Zhou P, Luan M, Yang S, Chen X, Carroll L, Williams NM, O'Donovan MC, Kirov G, Owen MJ |
Journal of biomedicine & biotechnology | 2009 |
Genetic variation in the schizophrenia-risk gene neuregulin 1 correlates with brain activation and impaired speech production in a verbal fluency task in healthy individuals.
Kircher T, Krug A, Markov V, Whitney C, Krach S, Zerres K, Eggermann T, Stöcker T, Shah NJ, Treutlein J, Nöthen MM, Becker T, Rietschel M |
Human Brain Mapping | 2009 |
A MicroRNA gene is hosted in an intron of a schizophrenia-susceptibility gene.
Zhu Y, Kalbfleisch T, Brennan MD, Li Y |
Schizophrenia Research | 2009 |
Exploratory eye movement dysfunction as a discriminator for schizophrenia : a large sample study using a newly developed digital computerized system.
Suzuki M, Takahashi S, Matsushima E, Tsunoda M, Kurachi M, Okada T, Hayashi T, Ishii Y, Morita K, Maeda H, Katayama S, Kawahara R, Otsuka T, Hirayasu Y, Sekine M, Okubo Y, Motoshita M, Ohta K, Uchiyama M, Kojima T |
European Archives of Psychiatry and Clinical Neuroscience | 2009 |
SNAP-25 in neuropsychiatric disorders.
Corradini I, Verderio C, Sala M, Wilson MC, Matteoli M |
Annals of the New York Academy of Sciences | 2009 |