Chronic lymphocytic leukemia and the inducement of a nongenetic adaptation to ibrutinib

In this episode, Laura Ondrisova describes how this manuscript examines a non-genetic adaptation to BTK inhibitor therapy in chronic lymphocytic leukemia that involves Akt activation via FoxO1/Rictor axis.

Macrophage subtypes mediate the development of the ordered architecture of regenerative tissues

In this episode, Andreas Patsalos and Laszlo Nagy explain that their findings suggest that macrophage subtypes mediated the development of the highly ordered architecture of regenerative tissues, unveiling the principles of the structured yet dynamic nature of regenerative inflammation supporting effective tissue repair.

JCI’s Conversations with Giants in Medicine: JCI Editors in Chief

In this episode, Ushma Neill speaks with the living Editors in Chief of the Journal of Clinical Investigation. They were asked to reflect on their time as editors and their favorite memories.

A dynamic multilayered tissue architecture is revealed in skeletal muscle

In this episode, Laszlo Nagy and colleagues, explain that macrophages coordinate tissue repair by promoting regenerative inflammation. They discovered diverse myeloid cell subsets that organize in functional multilayered tissue zones, crucial for effective muscle repair.

Happy 100th birthday, JCI!

Former JCI editors in chief wish the Journal of Clinical Investigation a happy 100th birthday!