Videos
In this episode, Hugo Bellen explains how these findings establish the AMG pathway as a mechanistic framework for identifying digenic etiologies in epilepsy and highlight potential therapeutic targets.
The American Society for Clinical Investigation (ASCI) honors Arul M. Chinnaiyan, MD, PhD, and Charles L. Sawyers, MD, with the 2026 ASCI/Harrington Prize for Innovation in Medicine. Drs. Chinnaiyan and Sawyers are recognized for their discoveries defining the molecular drivers of prostate cancer and pioneering precision therapies that have reshaped the diagnosis and treatment of prostate cancer worldwide. Dr. Chinnaiyan is the S.P. Hicks Endowed Professor of Pathology and Section Head, Michigan Center for Translational Pathology, at the University of Michigan, and a Howard Hughes Medical Institute (HHMI) Investigator. He was elected to the ASCI in 2006. Dr. Sawyers is the Marie-Josée and Henry R. Kravis Chair in Human Oncology and Pathogenesis and Chair, Human Oncology and Pathogenesis Program, at Memorial Sloan Kettering Cancer Center, as well as an HHMI Investigator. He was elected in 1999. ASCI Secretary-Treasurer Goutham Narla, Louis Newburgh Research Professor of Internal Medicine at the University of Michigan School of Medicine, interviewed the award recipients in June 2026.
The American Society for Clinical Investigation (ASCI) honors Kevin N. Sheth, MD, with the 2026 ASCI/Bruce F. Scharschmidt and Peggy S. Crawford Translational Medicine Award. Dr. Sheth is recognized for his transformative work deploying portable, low-field MRI systems allowing a safe, patient-centered bedside diagnosis. He is director of the Yale Center for Brain and Mind Health and vice chair for Clinical and Translational Research in the Departments of Neurology and Neurosurgery. Dr. Sheth was elected to the ASCI in 2020. Immediate Past President Dr. Anna Greka of the Broad Institute, Harvard Medical School, and Brigham & Women’s Hospital, interviewed Dr. Sheth at the ASCI/Association of American Physicians/American Physician-Scientists Association Joint Meeting in May 2026.
In this episode, Fouad Chebib explains that these findings support a vasopressin-independent urate/AMPK/AQP2 pathway that regulates renal water handling and, in a preclinical ADPKD model, can uncouple cyst growth attenuation from the dose-limiting aquaretic effects of V2R antagonism.
The American Society for Clinical Investigation (ASCI) honors Julie Zikherman, MD, with the ASCI/Marian W. Ropes, MD, Award. Dr. Zikherman is recognized for her outstanding research revealing the mechanisms of B cell tolerance that restrain autoimmunity and her dedication to mentorship. She is an Associate Professor in the Department of Medicine at UCSF and serves as Associate Chief for Basic Research in the Division of Rheumatology. Among other leadership positions, she serves on the UCSF Physician-Scientist Scholar Program Steering Committee and the Physician-Scientist Career Development Program Advisory Council. Dr. Zikherman was elected to the ASCI in 2021. ASCI President-Elect Dr. Julie A. Bastarache, Associate Professor in the Department of Medicine, Allergy, Pulmonary and Critical Care Medicine at Vanderbilt University Medical Center, interviewed Dr. Zikherman at the AAP/ASCI/APSA Joint Meeting in Chicago in April 2026.
Copyright © 2026 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)