Videos
In this episode, Stephen Chan, Satoshi Okawa, and Yinan Shi describe how connections between vascular and neurocognitive diseases are emerging but remain poorly defined. Cognitive impairment is increasingly recognized in pulmonary hypertension, a disease traditionally viewed as limited to the heart and lungs. Their findings identify NCOA7-linked inflammatory dysfunction in the cerebellar-frontal axis in PH, redefining this disease with neurologic consequences and thus offering neural targets for diagnostic, prognostic, and therapeutic development.
In this episode, Hugo Bellen explains how these findings establish the AMG pathway as a mechanistic framework for identifying digenic etiologies in epilepsy and highlight potential therapeutic targets.
The American Society for Clinical Investigation (ASCI) honors Arul M. Chinnaiyan, MD, PhD, and Charles L. Sawyers, MD, with the 2026 ASCI/Harrington Prize for Innovation in Medicine. Drs. Chinnaiyan and Sawyers are recognized for their discoveries defining the molecular drivers of prostate cancer and pioneering precision therapies that have reshaped the diagnosis and treatment of prostate cancer worldwide. Dr. Chinnaiyan is the S.P. Hicks Endowed Professor of Pathology and Section Head, Michigan Center for Translational Pathology, at the University of Michigan, and a Howard Hughes Medical Institute (HHMI) Investigator. He was elected to the ASCI in 2006. Dr. Sawyers is the Marie-Josée and Henry R. Kravis Chair in Human Oncology and Pathogenesis and Chair, Human Oncology and Pathogenesis Program, at Memorial Sloan Kettering Cancer Center, as well as an HHMI Investigator. He was elected in 1999. ASCI Secretary-Treasurer Goutham Narla, Louis Newburgh Research Professor of Internal Medicine at the University of Michigan School of Medicine, interviewed the award recipients in June 2026.
The American Society for Clinical Investigation (ASCI) honors Kevin N. Sheth, MD, with the 2026 ASCI/Bruce F. Scharschmidt and Peggy S. Crawford Translational Medicine Award. Dr. Sheth is recognized for his transformative work deploying portable, low-field MRI systems allowing a safe, patient-centered bedside diagnosis. He is director of the Yale Center for Brain and Mind Health and vice chair for Clinical and Translational Research in the Departments of Neurology and Neurosurgery. Dr. Sheth was elected to the ASCI in 2020. Immediate Past President Dr. Anna Greka of the Broad Institute, Harvard Medical School, and Brigham & Women’s Hospital, interviewed Dr. Sheth at the ASCI/Association of American Physicians/American Physician-Scientists Association Joint Meeting in May 2026.
In this episode, Fouad Chebib explains that these findings support a vasopressin-independent urate/AMPK/AQP2 pathway that regulates renal water handling and, in a preclinical ADPKD model, can uncouple cyst growth attenuation from the dose-limiting aquaretic effects of V2R antagonism.
Copyright © 2026 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)