Bone growth promotion in two FGFR3-driven models of chondrodysplasia

In this episode, Jacqueline Starrett and Will Charlton describe how TYRA-300, an FGFR3-selective kinase inhibitor, increases bone growth in mouse models of achondroplasia and hypochondroplasia.

The authors thank Rob Wishnowsky of Cruxio, Inc., and Fernando de Miguel for support creating the video abstract.

Response to immunotherapy in metastatic urothelial cancer and multimodal integration of blood

In this episode, Davide Croci, Sandra van Wilpe, and Niven Mehra explain that their manuscript predicts clinical benefit to immunotherapy by analyzing combined biomarkers from circulating tumor DNA and immune cell gene expression data in blood.

MD-PhD program admissions: application metrics and predicting outcomes

In this episode, Skip Brass and Myles Akabas explain how the results of their manuscript show that none of the applicant metrics, individually or collectively, predict in-program performance, future research effort, or eventual workplace choices even when comparisons were limited to those in the top and bottom quintiles.

Brain toxicity via kidney injury is potentially linked by quinolinic acid

In this Episode, Kumar Sharma and Afaf Saliba explain the potential link to kidney injury through brain toxicity due to quinolinic acid.

Gut inflammation in mice is alleviated by glucose-dependent insulinotropic polypeptide receptor

In this episode, Rola Hammoud explains that the paper demonstrates that activation versus loss of GIP action impacts the extent of experimental gut inflammation in mice.