Senescence and immunogenicity in medulloblastoma models are regulated by protein phosphatase 2A

In this episode, Rongze Olivia Lu, explains that the manuscript's findings identify PP2A as a regulator of immunogenic senescence in MB and support PP2Ac targeting as a therapeutic strategy.

Poststroke outcomes and glymphatic function in mice are improved by chronotherapy

In this episode, Lauren Hablitz describes how the manuscript's findings suggest that reinforcing normal daily rhythmicity after stroke can markedly enhance neurological recovery, even when interventions are initiated several days after stroke onset.

Crimean-Congo hemorrhagic fever virus glycoprotein 38 in mice is targeted with human antibodies

In this episode, James Crowe describes how these studies support the development of CCHFV countermeasures to induce protection against GP38 in vivo.

Wolfram syndrome and a phase II trial of sodium phenylbutyrate and taurursodiol

In this episode, Fumihiko Urano describes how the manuscript reports 24- and 48-week results from the ongoing HELIOS trial (ClinicalTrials.gov NCT05676034), a single-center, single-arm, open-label, phase II trial of PB&TURSO. Collectively, these results support continued development of PB&TURSO.

Distal wound healing is regulated by peritoneal macrophages via endocrine release

In this episode, Guido Beldi and Lilian Salm explain how their findings suggest that large peritoneal macrophages (LPMs), strategically positioned in the peritoneal cavity, serve as a source of circulating fibronectin, promoting matrix formation and accelerating wound healing at distant sites.