Pulmonary artery endothelial function and hypertension are impacted by RAB7 deficiency

In this episode, Laszlo Farkas explains that the results of this study indicate that reduced endothelial expression of endolysosomal RAB7 causes dysregulation of autophagy, mitochondrial dysfunction and endothelial senescence, and induces spontaneous PH.

Microglial activation and tau transmission aggravated by Galectin-3 in tauopathy

In this episode, Yijuang Chern and Jian Jing Siew discuss the novel role of Gal3 in the regulation of extracellular vesicles, promotion of pathogenic tau fibrillation, and microglial activation.

Numerous shared tumor antigens in breast cancer immunopeptidomes

In this episode, Eralda Kina and Claude Perreault explain how using proteogenomics, their manuscript identifies tumor-specific antigens in primary human breast cancers. These antigens are more numerous in triple-negative tumors and represent attractive targets for immunotherapy.

Suppression by regulatory T cells and Foxp3-mediated blockage of ryanodine receptor 2

In this episode, Xiaobo Wang, Shuang Geng, and Junchen Meng explain how this work reestablished the suppressive functions in Tconvs absence of Foxp3 indistinguishable from Tregs by simply blocking RyR2 expression.

Predicting diabetic kidney disease and mediating kidney injury in patients with endogenous adenine

In this episode, Kumar Sharma explains that urine adenine/creatinine is a marker for kidney failure in patients with diabetes, and endogenous adenine plays a potential causative role in diabetic kidney disease.