Sex- and age-specific differences revealed by mouse sarcopenia models

In this episode, Jose Garcia and Haiming Kerr describe how their study characterizes sarcopenia in aged mice using a clinically relevant definition, elucidating age-related changes in muscle mass and function, and the underlying molecular mechanisms in male and female mice.

Tet2 function and innate immune resistance to bacterial pneumonia

In this episode, Candice Quin explains how individuals with TET2-mutant CHIP are at increased risk of bacterial pneumonia due to innate immune impairments.

Prolonged transplant survival in preclinical models

In this episode, Leonardo Riella presents his manuscript detailing how a humanized mutein IL-2 selectively expands and boosts the function of mouse, non-human primate and human regulatory T cells, prolonging allograft survival.

A glycolysis/HIF1a axis in promoting G-MDSC activity and biofilm persistence during PJI is important

In this episode, Tammy Kielian, Kevin Garvin, Christopher Horn, and Prabhakar Arumugam describe how their study demonstrates the importance of a glycolysis/HIF1a axis in promoting G-MDSC anti-inflammatory activity and biofilm persistence during PJI.

Thrombotic microangiopathy is prevented in a case series of pig-to-human kidney xenotransplantation

In this episode, Jayme Locke and Maggie Jones-Carr explain the histologic outcomes of a series of brain-dead human recipients of a porcine kidney xenotransplant using exclusively FDA-approved medications, with and without anti-C5 monoclonal antibody.