Video abstracts
In this video collection, authors of findings published in The Journal of Clinical Investigation present personally guided tours of their results. The journal accepts video submissions from authors of recently accepted manuscripts. Instructions can be found on the Video Abstracts Guidelines page.
In this episode, Rafael Kramann, Konrad Hoeft, and Lars Koch explain that catalytically active ADAMTS12 controls fibrosis by restructuring ECM to enable activation and migration of a distinct injury-responsive fibroblast subset after injury.
In this episode, Jose Garcia and Haiming Kerr describe how their study characterizes sarcopenia in aged mice using a clinically relevant definition, elucidating age-related changes in muscle mass and function, and the underlying molecular mechanisms in male and female mice.
In this episode, Candice Quin explains how individuals with TET2-mutant CHIP are at increased risk of bacterial pneumonia due to innate immune impairments.
In this episode, Leonardo Riella presents his manuscript detailing how a humanized mutein IL-2 selectively expands and boosts the function of mouse, non-human primate and human regulatory T cells, prolonging allograft survival.
A glycolysis/HIF1a axis in promoting G-MDSC activity and biofilm persistence during PJI is important
In this episode, Tammy Kielian, Kevin Garvin, Christopher Horn, and Prabhakar Arumugam describe how their study demonstrates the importance of a glycolysis/HIF1a axis in promoting G-MDSC anti-inflammatory activity and biofilm persistence during PJI.
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ISSN: 0021-9738 (print), 1558-8238 (online)