Genetic epidemiological studies suggest that individual variation in susceptibility to schizophrenia is largely genetic, reflecting alleles of moderate to small effect in multiple genes. Molecular genetic studies have identified a number of potential regions of linkage and 2 associated chromosomal abnormalities, and accumulating evidence favors several positional candidate genes. These findings are grounds for optimism that insight into genetic factors associated with schizophrenia will help further our understanding of this disease and contribute to the development of new ways to treat it.
George Kirov, Michael C. O’Donovan, Michael J. Owen
Title and authors | Publication | Year |
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Glutamate and Schizophrenia: Beyond the Dopamine Hypothesis
JT Coyle |
Cellular and Molecular Neurobiology | 2006 |
Substance use disorders and schizophrenia: A question of shared glutamatergic mechanisms
JT Coyle |
Neurotoxicity Research | 2006 |
Segmental uniparental isodisomy on 5q32-qter in a patient with childhood-onset schizophrenia.
Seal JL, Gornick MC, Gogtay N, Shaw P, Greenstein DK, Coffey M, Gochman PA, Stromberg T, Chen Z, Merriman B, Nelson SF, Brooks J, Arepalli S, Wavrant-De Vrièze F, Hardy J, Rapoport JL, Addington AM |
Journal of medical genetics | 2006 |
Association of Huntington's disease and schizophrenia-like psychosis in a Huntington's disease pedigree.
Corrêa BB, Xavier M, Guimarães J |
Clinical practice and epidemiology in mental health : CP & EMH | 2006 |