Genetic epidemiological studies suggest that individual variation in susceptibility to schizophrenia is largely genetic, reflecting alleles of moderate to small effect in multiple genes. Molecular genetic studies have identified a number of potential regions of linkage and 2 associated chromosomal abnormalities, and accumulating evidence favors several positional candidate genes. These findings are grounds for optimism that insight into genetic factors associated with schizophrenia will help further our understanding of this disease and contribute to the development of new ways to treat it.
George Kirov, Michael C. O’Donovan, Michael J. Owen
Title and authors | Publication | Year |
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Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia
JE Lisman, JT Coyle, RW Green, DC Javitt, FM Benes, S Heckers, AA Grace |
Trends in Neurosciences | 2008 |
Association analyses of the interaction between the ADSS and ATM genes with schizophrenia in a Chinese population.
Zhang F, Xu Y, Liu P, Fan H, Huang X, Sun G, Song Y, Sham PC |
BMC Medical Genetics | 2008 |
Genomic convergence analysis of schizophrenia: mRNA sequencing reveals altered synaptic vesicular transport in post-mortem cerebellum.
Mudge J, Miller NA, Khrebtukova I, Lindquist IE, May GD, Huntley JJ, Luo S, Zhang L, van Velkinburgh JC, Farmer AD, Lewis S, Beavis WD, Schilkey FD, Virk SM, Black CF, Myers MK, Mader LC, Langley RJ, Utsey JP, Kim RW, Roberts RC, Khalsa SK, Garcia M, Ambriz-Griffith V, Harlan R, Czika W, Martin S, Wolfinger RD, Perrone-Bizzozero NI, Schroth GP, Kingsmore SF |
PloS one | 2008 |
An association study of ADSS gene polymorphisms with schizophrenia.
Zhang F, Sham PC, Fan H, Xu Y, Huang X, So H, Song Y, Liu P |
Behavioral and brain functions : BBF | 2008 |
Association of SNPs and haplotypes in APOL1, 2 and 4 with schizophrenia.
Takahashi S, Cui YH, Han YH, Fagerness JA, Galloway B, Shen YC, Kojima T, Uchiyama M, Faraone SV, Tsuang MT |
Schizophrenia Research | 2008 |
Association study in the 5q31-32 linkage region for schizophrenia using pooled DNA genotyping.
Zaharieva I, Georgieva L, Nikolov I, Kirov G, Owen MJ, O'Donovan MC, Toncheva D |
BMC psychiatry | 2008 |