Genetic epidemiological studies suggest that individual variation in susceptibility to schizophrenia is largely genetic, reflecting alleles of moderate to small effect in multiple genes. Molecular genetic studies have identified a number of potential regions of linkage and 2 associated chromosomal abnormalities, and accumulating evidence favors several positional candidate genes. These findings are grounds for optimism that insight into genetic factors associated with schizophrenia will help further our understanding of this disease and contribute to the development of new ways to treat it.
George Kirov, Michael C. O’Donovan, Michael J. Owen
Title and authors | Publication | Year |
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Brain structural correlates of familial risk for mental illness: a meta-analysis of voxel-based morphometry studies in relatives of patients with psychotic or mood disorders.
Zhang W, Sweeney JA, Yao L, Li S, Zeng J, Xu M, Tallman MJ, Gong Q, DelBello MP, Lui S, Nery FG |
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology | 2020 |
Shared and distinct alterations of white matter tracts in remitted and nonremitted patients with schizophrenia.
Huang JY, Liu CM, Hwang TJ, Chen YJ, Hsu YC, Hwu HG, Lin YT, Hsieh MH, Liu CC, Chien YL, Tseng WI |
Human Brain Mapping | 2018 |
Toward dissecting the etiology of schizophrenia: HDAC1 and DAXX regulate GAD67 expression in an in vitro hippocampal GABA neuron model.
Subburaju S, Coleman AJ, Ruzicka WB, Benes FM |
Translational Psychiatry | 2016 |
Association between upstream purine complexes of human caveolin-1 gene and schizophrenia in qazvin province of iran.
Najafipour R, Heidari A, Alizadeh SA, Ghafelebashi H, Rashvand Z, Javadi A, Moradi M, Afshar H |
Iranian Red Crescent Medical Journal | 2014 |
In vivo magnetic resonance studies reveal neuroanatomical and neurochemical abnormalities in the serine racemase knockout mouse model of schizophrenia.
Puhl MD, Mintzopoulos D, Jensen JE, Gillis TE, Konopaske GT, Kaufman MJ, Coyle JT |
Neurobiology of Disease | 2014 |
Association study of H2AFZ with schizophrenia in a Japanese case-control sample.
Jitoku D, Yamamoto N, Iwayama Y, Toyota T, Miyagi M, Enokida T, Tasaka Y, Umino M, Umino A, Uezato A, Iwata Y, Suzuki K, Kikuchi M, Hashimoto T, Kanahara N, Kurumaji A, Yoshikawa T, Nishikawa T |
Journal of neural transmission (Vienna, Austria : 1996) | 2014 |
Genetic variations of PIP4K2A confer vulnerability to poor antipsychotic response in severely ill schizophrenia patients.
Kaur H, Jajodia A, Grover S, Baghel R, Gupta M, Jain S, Kukreti R |
PloS one | 2014 |
A genome-wide association analysis of a broad psychosis phenotype identifies three loci for further investigation.
Bramon E, Pirinen M, Strange A, Lin K, Freeman C, Bellenguez C, Su Z, Band G, Pearson R, Vukcevic D, Langford C, Deloukas P, Hunt S, Gray E, Dronov S, Potter SC, Tashakkori-Ghanbaria A, Edkins S, Bumpstead SJ, Arranz MJ, Bakker S, Bender S, Bruggeman R, Cahn W, Chandler D, Collier DA, Crespo-Facorro B, Dazzan P, de Haan L, Di Forti M, Dragović M, Giegling I, Hall J, Iyegbe C, Jablensky A, Kahn RS, Kalaydjieva L, Kravariti E, Lawrie S, Linszen DH, Mata I, McDonald C, McIntosh A, Myin-Germeys I, Ophoff RA, Pariante CM, Paunio T, Picchioni M, Ripke S, Rujescu D, Sauer H, Shaikh M, Sussmann J, Suvisaari J, Tosato S, Toulopoulou T, Van Os J, Walshe M, Weisbrod M, Whalley H, Wiersma D, Blackwell JM, Brown MA, Casas JP, Corvin A, Duncanson A, Jankowski JA, Markus HS, Mathew CG, Palmer CN, Plomin R, Rautanen A, Sawcer SJ, Trembath RC, Wood NW, Barroso I, Peltonen L, Lewis CM, Murray RM, Donnelly P, Powell J, Spencer CC |
Biological Psychiatry | 2013 |
Clinical applications of schizophrenia genetics: genetic diagnosis, risk, and counseling in the molecular era.
Costain G, Bassett AS |
The Application of Clinical Genetics | 2012 |
The peroxisome: an update on mysteries.
Islinger M, Grille S, Fahimi HD, Schrader M |
Histochemistry and Cell Biology | 2012 |
Kynurenine 3-monooxygenase polymorphisms: relevance for kynurenic acid synthesis in patients with schizophrenia and healthy controls.
Holtze M, Saetre P, Engberg G, Schwieler L, Werge T, Andreassen OA, Hall H, Terenius L, Agartz I, Jönsson EG, Schalling M, Erhardt S |
Journal of psychiatry & neuroscience : JPN | 2012 |
Increased expression of receptor phosphotyrosine phosphatase-β/ζ is associated with molecular, cellular, behavioral and cognitive schizophrenia phenotypes.
Takahashi N, Sakurai T, Bozdagi-Gunal O, Dorr NP, Moy J, Krug L, Gama-Sosa M, Elder GA, Koch RJ, Walker RH, Hof PR, Davis KL, Buxbaum JD |
Translational Psychiatry | 2011 |
A brief review on recent developments in animal models of schizophrenia.
Trivedi MS, Jarbe T |
Indian journal of pharmacology | 2011 |
Association study between BDNF C-281A polymorphism and paranoid schizophrenia in Polish population.
Suchanek R, Owczarek A, Kowalski J |
Journal of molecular neuroscience : MN | 2011 |
Mean diffusivity and fractional anisotropy as indicators of disease and genetic liability to schizophrenia.
Clark KA, Nuechterlein KH, Asarnow RF, Hamilton LS, Phillips OR, Hageman NS, Woods RP, Alger JR, Toga AW, Narr KL |
Journal of Psychiatric Research | 2011 |
Genetic variation in G72 correlates with brain activation in the right middle temporal gyrus in a verbal fluency task in healthy individuals.
Krug A, Markov V, Krach S, Jansen A, Zerres K, Eggermann T, Stöcker T, Shah NJ, Nöthen MM, Georgi A, Strohmaier J, Rietschel M, Kircher T |
Human Brain Mapping | 2011 |
Dysregulation of presynaptic calcium and synaptic plasticity in a mouse model of 22q11 deletion syndrome.
Earls LR, Bayazitov IT, Fricke RG, Berry RB, Illingworth E, Mittleman G, Zakharenko SS |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2010 |
[Cognitive disorders in schizophrenic patients].
Volz HP, Reischies F, Riedel M |
Der Nervenarzt | 2010 |
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
Accept or refuse? A pilot study of patients' perspective on participating as imaginary research subjects in schizophrenia.
Kim JH, Kim D, Park SH, Nam J |
Psychiatry investigation | 2009 |
Whole genome association study in a homogenous population in Shandong peninsula of China reveals JARID2 as a susceptibility gene for schizophrenia.
Liu Y, Chen G, Norton N, Liu W, Zhu H, Zhou P, Luan M, Yang S, Chen X, Carroll L, Williams NM, O'Donovan MC, Kirov G, Owen MJ |
Journal of biomedicine & biotechnology | 2009 |
Genetic variation in the schizophrenia-risk gene neuregulin 1 correlates with brain activation and impaired speech production in a verbal fluency task in healthy individuals.
Kircher T, Krug A, Markov V, Whitney C, Krach S, Zerres K, Eggermann T, Stöcker T, Shah NJ, Treutlein J, Nöthen MM, Becker T, Rietschel M |
Human Brain Mapping | 2009 |
A MicroRNA gene is hosted in an intron of a schizophrenia-susceptibility gene.
Zhu Y, Kalbfleisch T, Brennan MD, Li Y |
Schizophrenia Research | 2009 |
Exploratory eye movement dysfunction as a discriminator for schizophrenia : a large sample study using a newly developed digital computerized system.
Suzuki M, Takahashi S, Matsushima E, Tsunoda M, Kurachi M, Okada T, Hayashi T, Ishii Y, Morita K, Maeda H, Katayama S, Kawahara R, Otsuka T, Hirayasu Y, Sekine M, Okubo Y, Motoshita M, Ohta K, Uchiyama M, Kojima T |
European Archives of Psychiatry and Clinical Neuroscience | 2009 |
SNAP-25 in neuropsychiatric disorders.
Corradini I, Verderio C, Sala M, Wilson MC, Matteoli M |
Annals of the New York Academy of Sciences | 2009 |
Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia
JE Lisman, JT Coyle, RW Green, DC Javitt, FM Benes, S Heckers, AA Grace |
Trends in Neurosciences | 2008 |
Association analyses of the interaction between the ADSS and ATM genes with schizophrenia in a Chinese population.
Zhang F, Xu Y, Liu P, Fan H, Huang X, Sun G, Song Y, Sham PC |
BMC Medical Genetics | 2008 |
Genomic convergence analysis of schizophrenia: mRNA sequencing reveals altered synaptic vesicular transport in post-mortem cerebellum.
Mudge J, Miller NA, Khrebtukova I, Lindquist IE, May GD, Huntley JJ, Luo S, Zhang L, van Velkinburgh JC, Farmer AD, Lewis S, Beavis WD, Schilkey FD, Virk SM, Black CF, Myers MK, Mader LC, Langley RJ, Utsey JP, Kim RW, Roberts RC, Khalsa SK, Garcia M, Ambriz-Griffith V, Harlan R, Czika W, Martin S, Wolfinger RD, Perrone-Bizzozero NI, Schroth GP, Kingsmore SF |
PloS one | 2008 |
An association study of ADSS gene polymorphisms with schizophrenia.
Zhang F, Sham PC, Fan H, Xu Y, Huang X, So H, Song Y, Liu P |
Behavioral and brain functions : BBF | 2008 |
Association of SNPs and haplotypes in APOL1, 2 and 4 with schizophrenia.
Takahashi S, Cui YH, Han YH, Fagerness JA, Galloway B, Shen YC, Kojima T, Uchiyama M, Faraone SV, Tsuang MT |
Schizophrenia Research | 2008 |
Association study in the 5q31-32 linkage region for schizophrenia using pooled DNA genotyping.
Zaharieva I, Georgieva L, Nikolov I, Kirov G, Owen MJ, O'Donovan MC, Toncheva D |
BMC psychiatry | 2008 |
Bioinformatic analysis of human CNS-expressed ion channels as candidates for episodic nervous system disorders
J Freudenberg, YH Fu, LJ Ptáček |
neurogenetics | 2007 |
Schizophrenia: from brain morphology to psychopathology.
Foster A, Usman M, Stirewalt E, Buckley P |
Current Psychiatry Reports | 2007 |
Comorbidity of substance abuse with other psychiatric disorders.
Palomo T, Archer T, Kostrzewa RM, Beninger RJ |
Neurotoxicity Research | 2007 |
Glutamate and Schizophrenia: Beyond the Dopamine Hypothesis
JT Coyle |
Cellular and Molecular Neurobiology | 2006 |
Substance use disorders and schizophrenia: A question of shared glutamatergic mechanisms
JT Coyle |
Neurotoxicity Research | 2006 |
Segmental uniparental isodisomy on 5q32-qter in a patient with childhood-onset schizophrenia.
Seal JL, Gornick MC, Gogtay N, Shaw P, Greenstein DK, Coffey M, Gochman PA, Stromberg T, Chen Z, Merriman B, Nelson SF, Brooks J, Arepalli S, Wavrant-De Vrièze F, Hardy J, Rapoport JL, Addington AM |
Journal of medical genetics | 2006 |
Association of Huntington's disease and schizophrenia-like psychosis in a Huntington's disease pedigree.
Corrêa BB, Xavier M, Guimarães J |
Clinical practice and epidemiology in mental health : CP & EMH | 2006 |
Mapping the new frontier: complex genetic disorders
R Mayeux |
Journal of Clinical Investigation | 2005 |