Genetic epidemiological studies suggest that individual variation in susceptibility to schizophrenia is largely genetic, reflecting alleles of moderate to small effect in multiple genes. Molecular genetic studies have identified a number of potential regions of linkage and 2 associated chromosomal abnormalities, and accumulating evidence favors several positional candidate genes. These findings are grounds for optimism that insight into genetic factors associated with schizophrenia will help further our understanding of this disease and contribute to the development of new ways to treat it.
George Kirov, Michael C. O’Donovan, Michael J. Owen
Title and authors | Publication | Year |
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Bioinformatic analysis of human CNS-expressed ion channels as candidates for episodic nervous system disorders
J Freudenberg, YH Fu, LJ Ptáček |
neurogenetics | 2007 |
Schizophrenia: from brain morphology to psychopathology.
Foster A, Usman M, Stirewalt E, Buckley P |
Current Psychiatry Reports | 2007 |
Comorbidity of substance abuse with other psychiatric disorders.
Palomo T, Archer T, Kostrzewa RM, Beninger RJ |
Neurotoxicity Research | 2007 |