Genetic epidemiological studies suggest that individual variation in susceptibility to schizophrenia is largely genetic, reflecting alleles of moderate to small effect in multiple genes. Molecular genetic studies have identified a number of potential regions of linkage and 2 associated chromosomal abnormalities, and accumulating evidence favors several positional candidate genes. These findings are grounds for optimism that insight into genetic factors associated with schizophrenia will help further our understanding of this disease and contribute to the development of new ways to treat it.
George Kirov, Michael C. O’Donovan, Michael J. Owen
Title and authors | Publication | Year |
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Association between upstream purine complexes of human caveolin-1 gene and schizophrenia in qazvin province of iran.
Najafipour R, Heidari A, Alizadeh SA, Ghafelebashi H, Rashvand Z, Javadi A, Moradi M, Afshar H |
Iranian Red Crescent Medical Journal | 2014 |
In vivo magnetic resonance studies reveal neuroanatomical and neurochemical abnormalities in the serine racemase knockout mouse model of schizophrenia.
Puhl MD, Mintzopoulos D, Jensen JE, Gillis TE, Konopaske GT, Kaufman MJ, Coyle JT |
Neurobiology of Disease | 2014 |
Association study of H2AFZ with schizophrenia in a Japanese case-control sample.
Jitoku D, Yamamoto N, Iwayama Y, Toyota T, Miyagi M, Enokida T, Tasaka Y, Umino M, Umino A, Uezato A, Iwata Y, Suzuki K, Kikuchi M, Hashimoto T, Kanahara N, Kurumaji A, Yoshikawa T, Nishikawa T |
Journal of neural transmission (Vienna, Austria : 1996) | 2014 |
Genetic variations of PIP4K2A confer vulnerability to poor antipsychotic response in severely ill schizophrenia patients.
Kaur H, Jajodia A, Grover S, Baghel R, Gupta M, Jain S, Kukreti R |
PloS one | 2014 |