This investigation was undertaken in order to (a) characterize the postprandial inflow of individual bile acids to the liver and (b) determine if peripheral venous bile acid levels always adequately reflect the portal venous concentration, or if saturation of hepatic bile acid uptake can occur under physiological conditions. In five patients with uncomplicated cholesterol gallstone disease, the umbilical cord was cannulated during cholecystectomy, and a catheter was left in the left portal branch for 5 to 7 d. The serum concentrations of cholic acid, chenodeoxycholic acid, and deoxycholic acid in portal venous and systemic circulation were then determined at intervals of 15 to 30 min before and after a standardized meal. A highly accurate and specific gas chromatographic/mass spectrometric technique was used.
Bo Angelin, Ingemar Björkhem, Kurt Einarsson, Staffan Ewerth
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Citations: | 5 | 3 | 9 | 12 | 7 | 10 | 5 | 5 | 4 | 9 | 11 | 2 | 1 | 1 | 4 | 3 | 1 | 5 | 2 | 2 | 1 | 3 | 1 | 1 | 2 | 1 | 3 | 3 | 2 | 5 | 3 | 4 | 2 | 5 | 5 | 8 | 5 | 11 | 4 | 3 | 1 | 174 |
Title and authors | Publication | Year |
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Bile acids in glucose metabolism and insulin signalling — mechanisms and research needs
TR Ahmad, RA Haeusler |
Nature Reviews Endocrinology | 2019 |
Bile acids drive colonic secretion of glucagon-like-peptide 1 and peptide-YY in rodents
CB Christiansen, SA Trammell, NJ Albrechtsen, K Schoonjans, R Albrechtsen, MP Gillum, RE Kuhre, JJ Holst |
AJP Gastrointestinal and Liver Physiology | 2019 |
Developments in bile salt based therapies: A critical overview
JM Donkers, RL Abbing, SF van de Graaf |
Biochemical Pharmacology | 2019 |
Systemic bile acids induce insulin resistance in a TGR5-independent manner
KE Syring, TJ Cyphert, TC Beck, CR Flynn, NA Mignemi, OP McGuinness |
American journal of physiology. Endocrinology and metabolism | 2019 |
A Physiology-Based Model of Human Bile Acid Metabolism for Predicting Bile Acid Tissue Levels After Drug Administration in Healthy Subjects and BRIC Type 2 Patients
V Baier, H Cordes, C Thiel, JV Castell, UP Neumann, LM Blank, L Kuepfer |
Frontiers in physiology | 2019 |
Bile acids and the metabolic syndrome
ER McGlone, SR Bloom |
Annals of Clinical Biochemistry | 2019 |
Acute Changes of Bile Acids and FGF19 After Sleeve Gastrectomy and Roux-en-Y Gastric Bypass
Y Chen, J Lu, R Nemati, LD Plank, R Murphy |
Obesity Surgery | 2019 |