Citations to this article
Citation Information: J Clin Invest. 1982;70(4):724-731. https://doi.org/10.1172/JCI110668.
Abstract
This investigation was undertaken in order to (a) characterize the postprandial inflow of individual bile acids to the liver and (b) determine if peripheral venous bile acid levels always adequately reflect the portal venous concentration, or if saturation of hepatic bile acid uptake can occur under physiological conditions. In five patients with uncomplicated cholesterol gallstone disease, the umbilical cord was cannulated during cholecystectomy, and a catheter was left in the left portal branch for 5 to 7 d. The serum concentrations of cholic acid, chenodeoxycholic acid, and deoxycholic acid in portal venous and systemic circulation were then determined at intervals of 15 to 30 min before and after a standardized meal. A highly accurate and specific gas chromatographic/mass spectrometric technique was used.
Authors
Bo Angelin, Ingemar Björkhem, Kurt Einarsson, Staffan Ewerth
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Citations to this article in year 2008 (3)
| Title and authors | Publication | Year |
|---|---|---|
|
Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity
O Shaham, R Wei, TJ Wang, C Ricciardi, GD Lewis, RS Vasan, SA Carr, R Thadhani, RE Gerszten, VK Mootha |
Molecular Systems Biology | 2008 |
|
Plasma carboxyl ester lipase activity modulates apolipoprotein B–containing lipoprotein metabolism in a transgenic mouse model
L Li, W Weng, EH Harrison, EA Fisher |
Metabolism | 2008 |
|
Expression and function of the bile acid receptor TGR5 in Kupffer cells
V Keitel, M Donner, S Winandy, R Kubitz, D Häussinger |
Biochemical and Biophysical Research Communications | 2008 |
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