JCI - Citations to Hepatic Uptake of Bile Acids in Man: FASTING AND POSTPRANDIAL CONCENTRATIONS OF INDIVIDUAL BILE ACIDS IN PORTAL VENOUS AND SYSTEMIC BLOOD SERUM

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Hepatic Uptake of Bile Acids in Man: FASTING AND POSTPRANDIAL CONCENTRATIONS OF INDIVIDUAL BILE ACIDS IN PORTAL VENOUS AND SYSTEMIC BLOOD SERUM

Bo Angelin, … , Kurt Einarsson, Staffan Ewerth

Bo Angelin, … , Kurt Einarsson, Staffan Ewerth

Published October 1, 1982
Citation Information: J Clin Invest. 1982;70(4):724-731. https://doi.org/10.1172/JCI110668.

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Hepatocyte apical bulkheads provide a mechanical means to oppose bile pressure Bebelman MP, Bovyn MJ, Mayer CM, Delpierre J, Naumann R, Martins NP, Honigmann A, Kalaidzidis Y, Haas PA, Zerial M	The Journal of Cell Biology	2023
Bile acid signaling in the regulation of whole body metabolic and immunological homeostasis. Jia W, Li Y, Cheung KCP, Zheng X	Science China Life Sciences	2023
Bile acid signalling and its role in anxiety disorders. Chen S, Shao Q, Chen J, Lv X, Ji J, Liu Y, Song Y	Frontiers in Endocrinology	2023
Duodenal-jejunal bypass reduces serum ceramides via inhibiting intestinal bile acid-farnesoid X receptor pathway Cheng ZQ, Liu TM, Ren PF, Chen C, Wang YL, Dai Y, Zhang X	World Journal of Gastroenterology	2022
Functional, Diagnostic and Therapeutic Aspects of Bile. Ahmed M	Clinical and experimental gastroenterology	2022
Dynamics and determinants of human plasma bile acid profiles during dietary challenges. Fiamoncini J, Rist MJ, Frommherz L, Giesbertz P, Pfrang B, Kremer W, Huber F, Kastenmüller G, Skurk T, Hauner H, Suhre K, Daniel H, Kulling SE	Frontiers in Nutrition	2022
Chenodeoxycholic Acid Modulates Bile Acid Synthesis Independent of Fibroblast Growth Factor 19 in Primary Human Hepatocytes H Johansson, JN Søndergaard, C Jorns, C Kutter, EC Ellis	Frontiers in Endocrinology	2021
Central anorexigenic actions of bile acids are mediated by TGR5 A Perino, LA Velázquez-Villegas, N Bresciani, Y Sun, Q Huang, VS Fénelon, A Castellanos-Jankiewicz, P Zizzari, G Bruschetta, S Jin, A Baleisyte, A Gioiello, R Pellicciari, J Ivanisevic, BL Schneider, S Diano, D Cota, K Schoonjans		2021
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Targeted LC-MS/MS Profiling of Bile Acids in Various Animal Tissues S Reiter, A Dunkel, C Dawid, T Hofmann	Journal of Agricultural and Food Chemistry	2021
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Circulating Bile Acid Profiles: A Need for Further Examination L Qi, Y Tian, Y Chen	The Journal of clinical endocrinology and metabolism	2021
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Bile acid metabolism is altered in multiple sclerosis and supplementation ameliorates neuroinflammation Pavan Bhargava, Matthew D. Smith, Leah Mische, Emily P. Harrington, Kathryn C. Fitzgerald, Kyle A. Martin, Sol Kim, Arthur Anthony A. Reyes, Jaime Gonzalez-Cardona, Christina Volsko, Ajai Tripathi, Sonal Singh, Kesava Varanasi, Hannah-Noelle Lord, Keya R. Meyers, Michelle Taylor, Marjan Gharagozloo, Elias S. Sotirchos, Bardia Nourbakhsh, Ranjan Dutta, Ellen Mowry, Emmanuelle Waubant, Peter A. Calabresi	Journal of Clinical Investigation	2020
Distinct Postprandial Bile Acids Responses to a High-Calorie Diet in Men Volunteers Underscore Metabolically Healthy and Unhealthy Phenotypes A Lamaziere, D Rainteau, P KC, L Humbert, E Gauliard, F Ichou, M Ponnaiah, N Bouby, JE Salem, JM Mallet, M Guerin, P Lesnik	Nutrients	2020
Hepatic Bile Acid Reuptake in the Rat Depends on Bile Acid Conjugation but Not on Agonistic Properties towards FXR and TGR5 SA Trammell, JS Svenningsen, JJ Holst, MP Gillum, RE Kuhre	Molecules (Basel, Switzerland)	2020
Bilio-enteric flow and plasma concentrations of bile acids after gastric bypass and sleeve gastrectomy A Eiken, S Fuglsang, M Eiken, MS Svane, RE Kuhre, NJ Albrechtsen, SH Hansen, SA Trammell, JS Svenningsen, JF Rehfeld, KN Bojsen-Møller, NB Jørgensen, JJ Holst, S Madsbad, JL Madsen, C Dirksen	International Journal of Obesity	2020
Modulation of immune responses by bile acid receptor agonists in myasthenia gravis Q Howlett-Prieto, C Langer, K Rezania, B Soliven	Journal of Neuroimmunology	2020
A Physiology-Based Model of Bile Acid Distribution and Metabolism Under Healthy and Pathologic Conditions in Human Beings V Voronova, V Sokolov, A Al-Khaifi, S Straniero, C Kumar, K Peskov, G Helmlinger, M Rudling, B Angelin	CMGH Cellular and Molecular Gastroenterology and Hepatology	2020
Unraveling Host-Gut Microbiota Dialogue and Its Impact on Cholesterol Levels R Villette, P KC, S Beliard, MF Tapia, D Rainteau, M Guerin, P Lesnik	Frontiers in pharmacology	2020
Biliary excretion of gadobenate dimeglumine causing degradation of magnetic resonance cholangiopancreatography (MRCP) LM Trunz, FF Guglielmo, SK Selvarajan, HV Naringrekar, A Alturki, JK Dave, DG Mitchell	Abdominal Radiology	2020
Regulation of bile acid metabolism in biliary atresia: reduction of FGF19 by Kasai portoenterostomy and possible relation to early outcome H Johansson, JF Svensson, M Almström, NV Hul, M Rudling, B Angelin, G Nowak, B Fischler, E Ellis	Journal of Internal Medicine	2020
Fasting serum total bile acid level is associated with coronary artery disease, myocardial infarction and severity of coronary lesions W Li, S Shu, L Cheng, X Hao, L Wang, Y Wu, Z Yuan, J Zhou	Atherosclerosis	2020
Bile Acids: A Communication Channel in the Gut-Brain Axis VF Monteiro-Cardoso, M Corlianò, RR Singaraja	NeuroMolecular Medicine	2020
Mammalian Sterols: Novel Biological Roles of Cholesterol Synthesis Intermediates, Oxysterols and Bile Acids D Rozman, R Gebhardt		2020
Bile acids in glucose metabolism and insulin signalling — mechanisms and research needs TR Ahmad, RA Haeusler	Nature Reviews Endocrinology	2019
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Developments in bile salt based therapies: A critical overview JM Donkers, RL Abbing, SF van de Graaf	Biochemical Pharmacology	2019
Systemic bile acids induce insulin resistance in a TGR5-independent manner KE Syring, TJ Cyphert, TC Beck, CR Flynn, NA Mignemi, OP McGuinness	American journal of physiology. Endocrinology and metabolism	2019
A Physiology-Based Model of Human Bile Acid Metabolism for Predicting Bile Acid Tissue Levels After Drug Administration in Healthy Subjects and BRIC Type 2 Patients V Baier, H Cordes, C Thiel, JV Castell, UP Neumann, LM Blank, L Kuepfer	Frontiers in physiology	2019
Bile acids and the metabolic syndrome ER McGlone, SR Bloom	Annals of Clinical Biochemistry	2019
Acute Changes of Bile Acids and FGF19 After Sleeve Gastrectomy and Roux-en-Y Gastric Bypass Y Chen, J Lu, R Nemati, LD Plank, R Murphy	Obesity Surgery	2019
Bile acids in glucose metabolism in health and disease H Shapiro, AA Kolodziejczyk, D Halstuch, E Elinav	Journal of Experimental Medicine	2018
Microbiome-mediated bile acid modification: Role in intestinal drug absorption and metabolism EF Enright, BT Griffin, CG Gahan, SA Joyce	Pharmacological research : the official journal of the Italian Pharmacological Society	2018
The role of bile acids in nutritional support G van Niekerk, T Davis, W de Villiers, AM Engelbrecht	Critical Care	2018
Circulating Fibroblast Growth Factor 19 in Portal and Systemic Blood H Johansson, LM Mörk, M Li, AL Sandblom, I Björkhem, J Höijer, BG Ericzon, C Jorns, S Gilg, E Sparrelid, B Isaksson, G Nowak, E Ellis	Journal of Clinical and Experimental Hepatology	2018
Pharmacometabolomics Informs About Pharmacokinetic Profile of Methylphenidate R Kaddurah-Daouk, T Hankemeier, EH Scholl, R Baillie, A Harms, C Stage, KP Dalhoff, G Jűrgens, O Taboureau, GS Nzabonimpa, AA Motsinger-Reif, R Thomsen, K Linnet, HB Rasmussen	CPT Pharmacometrics Syst. Pharmacol.	2018
Deoxycholylglycine, a conjugated secondary bile acid, reduces vascular tone by attenuating Ca 2+ sensitivity via rho kinase pathway RN Jadeja, MC Thounaojam, M Bartoli, S Khurana	Toxicology and Applied Pharmacology	2018
Model-Based Prediction of Plasma Concentration and Enterohepatic Circulation of Total Bile Acids in Humans B Guiastrennec, DP Sonne, M Bergstrand, T Vilsbøll, FK Knop, MO Karlsson	CPT Pharmacometrics Syst. Pharmacol.	2018
Removal of bile acids by extracorporeal therapies: an in vitro study J Hartmann, S Harm	The International Journal of Artificial Organs	2018
Cholestatic Drug Induced Liver Injury: A Function of Bile Salt Export Pump Inhibition and Farnesoid X Receptor Antagonism JP Jackson, KM Freeman, RL Claire, CB Black, KR Brouwer	Applied In Vitro Toxicology	2018
Asynchronous rhythms of circulating conjugated and unconjugated bile acids in the modulation of human metabolism A Al-Khaifi, S Straniero, V Voronova, D Chernikova, V Sokolov, C Kumar, B Angelin, M Rudling	Journal of Internal Medicine	2018
Bile Acid Uptake Transporters as Targets for Therapy D Slijepcevic, SF van de Graaf	Digestive Diseases	2017
Determinants of postprandial plasma bile acid kinetics in human volunteers J Fiamoncini, AM Yiorkas, K Gedrich, M Rundle, SI Alsters, G Roeselers, TJ van Broek, T Clavel, I Lagkouvardos, S Wopereis, G Frost, B Ommen, AI Blakemore, H Daniel	AJP Gastrointestinal and Liver Physiology	2017
Bariatric Surgery: A Perspective for Primary Care S Kizy, C Jahansouz, K Wirth, S Ikramuddin, D Leslie	Diabetes spectrum : a publication of the American Diabetes Association	2017
Transhepatic bile acid kinetics in pigs and humans HM Eggink, FS van Nierop, MG Schooneman, A Boelen, A Kalsbeek, M Koehorst, GA Have, LM de Brauw, AK Groen, JA Romijn, NE Deutz, MR Soeters	Clinical nutrition (Edinburgh, Scotland)	2017
Complex interaction between circadian rhythm and diet on bile acid homeostasis in male rats HM Eggink, JE Oosterman, P Goede, EM de Vries, E Foppen, M Koehorst, AK Groen, A Boelen, JA Romijn, SE la Fleur, MR Soeters, A Kalsbeek	Chronobiology International	2017
The Contributing Role of Bile Acids to Metabolic Improvements After Obesity and Metabolic Surgery F Fouladi, JE Mitchell, JA Wonderlich, KJ Steffen	Obesity Surgery	2016
Bile Acid Recognition by NAPE-PLD E Margheritis, B Castellani, P Magotti, S Peruzzi, E Romeo, F Natali, S Mostarda, A Gioiello, D Piomelli, G Garau	ACS chemical biology	2016
FXR Primes the Liver for Intestinal FGF15 Signaling by Transient Induction of β-Klotho T Fu, YC Kim, S Byun, DH Kim, S Seok, K Suino-Powell, HE Xu, B Kemper, JK Kemper	Molecular Endocrinology	2016
Age-Related Changes of Plasma Bile Acid Concentrations in Healthy Adults—Results from the Cross-Sectional KarMeN Study L Frommherz, A Bub, E Hummel, MJ Rist, A Roth, B Watzl, SE Kulling, AG Passi	PloS one	2016
Metabolic Syndrome and Diabetes M Kurian, BM Wolfe, S Ikramuddin		2016
Increased Bile Acid Synthesis and Impaired Bile Acid Transport in Human Obesity RA Haeusler, S Camastra, M Nannipieri, B Astiarraga, J Castro-Perez, D Xie, L Wang, M Chakravarthy, E Ferrannini	The Journal of clinical endocrinology and metabolism	2015
Expedited Biliopancreatic Juice Flow to the Distal Gut Benefits the Diabetes Control After Duodenal-Jejunal Bypass H Han, L Wang, H Du, J Jiang, C Hu, G Zhang, S Liu, X Zhang, T Liu, S Hu	Obesity Surgery	2015
Temporal changes in bile acid levels and 12α-hydroxylation after Roux-en-Y gastric bypass surgery in type 2 diabetes R Dutia, M Embrey, S O'Brien, RA Haeusler, KK Agénor, P Homel, J McGinty, RP Vincent, J Alaghband-Zadeh, B Staels, CW le Roux, J Yu, B Laferrère	International Journal of Obesity	2015
Metabolomics as a diagnostic tool for idiopathic non-cirrhotic portal hypertension S Seijo, JJ Lozano, C Alonso, R Miquel, A Berzigotti, E Reverter, F Turon, ML Martínez-Chantar, A Castro, JM Mato, V Hernández-Gea, J Bosch, JC García-Pagán	Liver International	2015
Activation of the bile acid receptor TGR5 enhances LPS-induced inflammatory responses in a human monocytic cell line K Mobraten, T Haugbro, E Karlstrom, CR Kleiveland, T Lea	Journal of Receptors and Signal Transduction	2014
Bile acids reduce endocytosis of high-density lipoprotein (HDL) in HepG2 cells C Röhrl, K Eigner, S Fruhwürth, H Stangl	PloS one	2014
Neuro-humoral signalling by bile acids and the TGR5 receptor in the gastrointestinal tract: Bile acid receptors NW Bunnett	The Journal of Physiology	2014
Key discoveries in bile acid chemistry and biology and their clinical applications: history of the last eight decades AF Hofmann, LR Hagey	Journal of lipid research	2014
Bile Acid Sequestrants: Glucose-Lowering Mechanisms and Efficacy in Type 2 Diabetes M Hansen, DP Sonne, FK Knop	Current Diabetes Reports	2014
Total Serum Bilirubin Predicts Fat-Soluble Vitamin Deficiency Better Than Serum Bile Acids in Infants With Biliary Atresia: VL Venkat, BL Shneider, JC Magee, Y Turmelle, R Arnon, JA Bezerra, PM Hertel, SJ Karpen, N Kerkar, KM Loomes, J Molleston, KF Murray, VL Ng, T Raghunathan, P Rosenthal, K Schwartz, AH Sherker, RJ Sokol, J Teckman, K Wang, PF Whitington, JE Heubi	Journal of Pediatric Gastroenterology and Nutrition	2014
On the role of gallbladder emptying and incretin hormones for nutrient-mediated TSH suppression in patients with type 2 diabetes DP Sonne, A Lund, J Faber, JJ Holst, T Vilsboll, FK Knop	Endocrine Connections	2014
A Study of the Relationship between Serum Bile Acids and Propranolol Pharmacokinetics and Pharmacodynamics in Patients with Liver Cirrhosis and in Healthy Controls AB Taegtmeyer, M Haschke, L Tchambaz, M Buylaert, M Tschöpl, U Beuers, J Drewe, S Krähenbühl, P Aspichueta	PloS one	2014
Fasting Serum Taurine-Conjugated Bile Acids Are Elevated in Type 2 Diabetes and Do Not Change With Intensification of Insulin M Wewalka, ME Patti, C Barbato, SM Houten, AB Goldfine	The Journal of clinical endocrinology and metabolism	2014
The TGR5 Receptor Mediates Bile Acid-Induced Itch and Analgesia Farzad Alemi, Edwin Kwon, Daniel Poole, Tinamarie Lieu, Victoria Lyo, Fiore Cattaruzza, Ferda Cevikbas, Martin Steinhoff, Romina Nassini, Serena Materazzi, Raquel Guerrero-Alba, Eduardo Valdez-Morales, Graeme Cottrell, Kristina Schoonjans, Pierangelo Geppetti, Stephen Vanner, Nigel W Bunnett, Carlos Corvera	Journal of Clinical Investigation	2013
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME P Godoy, NJ Hewitt, U Albrecht, ME Andersen, N Ansari, S Bhattacharya, JG Bode, J Bolleyn, C Borner, J Böttger, A Braeuning, RA Budinsky, B Burkhardt, NR Cameron, G Camussi, CS Cho, YJ Choi, JC Rowlands, U Dahmen, G Damm, O Dirsch, MT Donato, J Dong, S Dooley, D Drasdo, R Eakins, KS Ferreira, V Fonsato, J Fraczek, R Gebhardt, A Gibson, M Glanemann, CE Goldring, MJ Gómez-Lechón, GM Groothuis, L Gustavsson, C Guyot, D Hallifax, S Hammad, A Hayward, D Häussinger, C Hellerbrand, P Hewitt, S Hoehme, HG Holzhütter, JB Houston, J Hrach, K Ito, H Jaeschke, V Keitel, JM Kelm, BK Park, C Kordes, GA Kullak-Ublick, EL LeCluyse, P Lu, J Luebke-Wheeler, A Lutz, DJ Maltman, M Matz-Soja, P McMullen, I Merfort, S Messner, C Meyer, J Mwinyi, DJ Naisbitt, AK Nussler, P Olinga, F Pampaloni, J Pi, L Pluta, SA Przyborski, A Ramachandran, V Rogiers, C Rowe, C Schelcher, K Schmich, M Schwarz, B Singh, EH Stelzer, B Stieger, R Stöber, Y Sugiyama, C Tetta, WE Thasler, T Vanhaecke, M Vinken, TS Weiss, A Widera, CG Woods, JJ Xu, KM Yarborough, JG Hengstler	Archives of Toxicology	2013
Pleiotropic Roles of Bile Acids in Metabolism TQ de Aguiar Vallim, EJ Tarling, PA Edwards	Cell Metabolism	2013
Systemic bile acid sensing by G protein-coupled bile acid receptor 1 (GPBAR1) promotes PYY and GLP-1 release: Mechanism of GPBAR1-mediated PYY/GLP-1 release C Ullmer, RA Sanchez, U Sprecher, S Raab, P Mattei, H Dehmlow, S Sewing, A Iglesias, J Beauchamp, K Conde-Knape	British Journal of Pharmacology	2013
Transport and biological activities of bile acids BL Zwicker, LB Agellon	The International Journal of Biochemistry & Cell Biology	2013
TGR5 in cholangiocytes: V Keitel, D Häussinger	Current Opinion in Gastroenterology	2013
Bile acids and gut peptide secretion after bariatric surgery: A 1-year prospective randomized pilot trial: Bariatric Surgery, Bile Acids, and Gut Peptides RE Steinert, R Peterli, S Keller, AC Meyer-Gerspach, J Drewe, T Peters, C Beglinger	Obesity	2013
Fibroblast growth factor 19 in patients with bile acid diarrhoea: a prospective comparison of FGF19 serum assay and SeHCAT retention SS Pattni, WG Brydon, T Dew, IM Johnston, JD Nolan, M Srinivas, P Basumani, KD Bardhan, JR Walters	Alimentary Pharmacology & Therapeutics	2013
Roux-en-Y gastric bypass normalizes the blunted postprandial bile acid excursion associated with obesity NN Ahmad, A Pfalzer, LM Kaplan	International Journal of Obesity	2013
Enhanced fasting and post-prandial plasma bile acid responses after Roux-en-Y gastric bypass surgery M Werling, RP Vincent, GF Cross, HU Marschall, L Fändriks, H Lönroth, DR Taylor, J Alaghband-Zadeh, T Olbers, CW le Roux	Scandinavian Journal of Gastroenterology	2013
The Receptor TGR5 Mediates the Prokinetic Actions of Intestinal Bile Acids and Is Required for Normal Defecation in Mice F Alemi, DP Poole, J Chiu, K Schoonjans, F Cattaruzza, JR Grider, NW Bunnett, CU Corvera	Gastroenterology	2013
Conjugated Bile Acids Associate with Altered Rates of Glucose and Lipid Oxidation after Roux-en-Y Gastric Bypass M Simonen, N Dali-Youcef, D Kaminska, S Venesmaa, P Käkelä, M Pääkkönen, M Hallikainen, M Kolehmainen, M Uusitupa, L Moilanen, M Laakso, H Gylling, ME Patti, J Auwerx, J Pihlajamäki	Obesity Surgery	2012
Perspective: TGR5 (Gpbar-1) in liver physiology and disease V Keitel, D Häussinger	Clinics and Research in Hepatology and Gastroenterology	2012
Handbook of Behavior, Food and Nutrition VR Preedy, RR Watson, CR Martin		2011
Bile acids: short and long term effects in the intestine A Bajor, PG Gillberg, H Abrahamsson	Scandinavian Journal of Gastroenterology	2010
TGR5-mediated bile acid sensing controls glucose homeostasis C Thomas, A Gioiello, L Noriega, A Strehle, J Oury, G Rizzo, A Macchiarulo, H Yamamoto, C Mataki, M Pruzanski, R Pellicciari, J Auwerx, K Schoonjans	Cell Metabolism	2009
Serum Bile Acids Are Higher in Humans With Prior Gastric Bypass: Potential Contribution to Improved Glucose and Lipid Metabolism ME Patti, SM Houten, AC Bianco, R Bernier, PR Larsen, JJ Holst, MK Badman, E Maratos-Flier, EC Mun, J Pihlajamaki, J Auwerx, AB Goldfine	Obesity	2009
Circadian dysregulation disrupts bile acid homeostasis K Ma, R Xiao, HT Tseng, L Shan, L Fu, DD Moore	PloS one	2009
Efficacy of urine bile acid as a non-invasive indicator of liver damage in rats H Kawai, N Kudo, Y Kawashima, A Mitsumoto	The Journal of Toxicological Sciences	2009
Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity O Shaham, R Wei, TJ Wang, C Ricciardi, GD Lewis, RS Vasan, SA Carr, R Thadhani, RE Gerszten, VK Mootha	Molecular Systems Biology	2008
Plasma carboxyl ester lipase activity modulates apolipoprotein B–containing lipoprotein metabolism in a transgenic mouse model L Li, W Weng, EH Harrison, EA Fisher	Metabolism	2008
Expression and function of the bile acid receptor TGR5 in Kupffer cells V Keitel, M Donner, S Winandy, R Kubitz, D Häussinger	Biochemical and Biophysical Research Communications	2008
Bile Acids: Biological Actions and Clinical Relevance D Keppler, U Leuschner, M Trauner, U Beuers, A Stiehl, G Paumgartner		2007
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Circulating intestinal fibroblast growth factor 19 has a pronounced diurnal variation and modulates hepatic bile acid synthesis in man T Lundåsen, C Gälman, B Angelin, M Rudling	Journal of Internal Medicine	2006
PKCζ Is Required for Microtubule-Based Motility of Vesicles Containing the ntcp Transporter S Sarkar, E Bananis, S Nath, MS Anwer, AW Wolkoff, JW Murray	Traffic	2006
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Bile Acid Synthesis in Humans Has a Rapid Diurnal Variation That Is Asynchronous With Cholesterol Synthesis C Gälman, B Angelin, M Rudling	Gastroenterology	2005
Bile acids as carcinogens in human gastrointestinal cancers H Bernstein, C Bernstein, CM Payne, K Dvorakova, H Garewal	Mutation Research/Reviews in Mutation Research	2005
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Carboxyl ester lipase: structure-function relationship and physiological role in lipoprotein metabolism and atherosclerosis DY Hui, PN Howles	Journal of lipid research	2002
On the mechanism of bile acid inhibition of rat sterol 12α-hydroxylase gene (CYP8B1) transcription: roles of α-fetoprotein transcription factor and hepatocyte nuclear factor 4α Y Yang, M Zhang, G Eggertsen, JY Chiang	Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids	2002
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Unconjugated secondary bile acids in the serum of patients with colorectal adenomas E Bayerdorffer, GA Mannes, T Ochsenkuhn, P Dirschedl, B Wiebecke, G Paumgartner	Gut	1995
Hepatic uptake and intestinal absorption of bile acids in the rabbit R Aldini, A Roda, M Montagnani, C Polimeni, PL Lenzi, C Cerre, G Galletti, E Roda	European Journal of Clinical Investigation	1994
Apparent selective bile acid malabsorption as a consequence of ileal exclusion: effects on bile acid, cholesterol, and lipoprotein metabolism JE Akerlund, I Bjorkhem, B Angelin, L Liljeqvist, K Einarsson	Gut	1994
Effect of ageing on postprandial conjugated and unconjugated serum bile acid levels in healthy subjects JM Salemans, FM Nagengast, A Tangerman, AV Schaik, WP Hopman, AF de Haan, JB Jansen	European Journal of Clinical Investigation	1993
Studies in vitro on the influence of ursodeoxycholate sodium salt (UDC) on hepatocyte proliferation M Barone, C Panella, A Ancelini, D Romanelli, A Francavilla	Journal of Surgical Oncology	1993
Microtubule-dependent transport of bile salts through hepatocytes: Cholic vs. taurocholic acid JM Crawford, AR Crawford, DC Strahs	Hepatology	1993
Postprandial Conjugated and Unconjugated Serum Bile Acid Levels after Proctocolectomy with Ileal Pouch-Anal Anastomosis JM Salemans, FM Nagengast, A Tangerman, AV Schaik, AF de Haan, JB Jansen	Scandinavian Journal of Gastroenterology	1993
Comparative binding of bile acids to serum lipoproteins and albumin S Ceryak, B Bouscarel, H Fromm	Journal of lipid research	1993
Alteration of bile acid metabolism in two-thirds hepatectomized rat K Nakamura, H Ichimiya, F Nakayama	Journal of Gastroenterology and Hepatology	1992
Applications of isotope dilution-mass spectrometry in clinical chemistry, pharmacokinetics, and toxicology AP de Leenheer, LM Thienpont	Mass Spectrometry Reviews	1992
The influence of bile salts on small intestinal motility in the guinea pig in vitro Q Xu, EA Shaffer	Gastroenterology	1992
Measurement of total fasting-state serum bile acids: Comparison of a solid-phase bioluminescence enzymatic assay, a homogeneous fluorescence enzymatic assay and isotope dilution gas chromatography-mass spectrometry SS Rossi, MA Angellotti, KD Setchell, AF Hofmann	Clinica Chimica Acta	1991
Transcellular transport of organic anions in hepatocytes: Still a long way to go JM Crawford, JL Gollan	Hepatology	1991
Physical and biological properties of fluorescent dansylated bile salt derivatives: the role of steroid ring hydroxylation JM Crawford, YJ Lin, BA Teicher, JP Narciso, JL Gollan	Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism	1991
Bile acid sequestrants: Mechanisms of action on bile acid and cholesterol metabolism K Einarsson, S Ericsson, S Ewerth, E Reihnr, M Rudling, D Sthlberg, B Angelin	European Journal of Clinical Pharmacology	1991
Altered bile acid metabolism in liver disease: concurrent occurrence of C-1 and C-6 hydroxylated bile acid metabolites and their preferential excretion into urine J Shoda, N Tanaka, T Osuga, K Matsuura, H Miyazaki	Journal of lipid research	1990
Purification and characterization of a microbial, NADP-dependent bile acid 7 alpha-hydroxysteroid dehydrogenase CV Franklund, P de Prada, PB Hylemon	The Journal of biological chemistry	1990
Taurocholate transport by basolateral plasma membrane vesicles isolated from human liver DA Novak, FC Ryckman, FJ Suchy	Hepatology	1989
Unconjugated serum bile acids as a marker of small intestinal bacterial overgrowth A Masclee, A Tangerman, AV Schaik, EW Hoek, JH Tongeren	European Journal of Clinical Investigation	1989
Serum concentrations of unconjugated and conjugated cholic acid in portal venous and systemic venous blood of fasting man K Einarsson, E Reihnér, S Ewerth, I Björkhem	Scandinavian Journal of Clinical & Laboratory Investigation	1989
Bile acid synthesis in humans: Regulation of hepatic microsomal cholesterol 7α-hydroxylase activity E Reihnér, I Björkhem, B Angelin, S Ewerth, K Einarsson	Gastroenterology	1989
Concurrent occurrence of 3 beta,12 alpha-dihydroxy-5-cholenoic acid associated with 3 beta-hydroxy-5-cholenoic acid and their preferential urinary excretion in liver diseases J Shoda, T Osuga, K Matsuura, R Mahara, M Tohma, N Tanaka, Y Matsuzaki, H Miyazaki	Journal of lipid research	1989
Computer simulation of portal venous shunting and other isolated hepatobiliary defects of the enterohepatic circulation of bile acids using a physiological pharmacokinetic model C Cravetto, G Molino, AF Hofmann, G Belforte, B Bona	Hepatology	1988
Urinary excretion of bile acids during acute administration in man G Salvioli, R Lugli, JM Pradelli, A Frignani, V Boccalletti	European Journal of Clinical Investigation	1988
The Bile Acids: Chemistry, Physiology, and Metabolism KD Setchell, D Kritchevsky, PP Nair		1988
Formation of chenodeoxycholic acid from 3 alpha, 7 alpha-dihydroxy-5 beta-cholestanoic acid by rat liver peroxisomes K Prydz, BF Kase, I Björkhem, JI Pedersen	Journal of lipid research	1988
Role of the hepatocyte microtubular system in the excretion of bile salts and biliary lipid: implications for intracellular vesicular transport JM Crawford, CA Berken, JL Gollan	Journal of lipid research	1988
Bile acid metabolism in hereditary forms of hypertriglyceridemia: evidence for an increased synthesis rate in monogenic familial hypertriglyceridemia B Angelin, KS Hershon, JD Brunzell	Proceedings of the National Academy of Sciences	1987
Advances in the application of biochemical tests to diseases of the liver and biliary tract: Their role in diagnosis, prognosis, and the elucidation of pathogenetic mechanisms DM Goldberg, D Brown	Clinical Biochemistry	1987
Simulation of the metabolism and enterohepatic circulation of endogenous deoxycholic acid in humans using a physiologic pharmacokinetic model for bile acid metabolism AF Hofmann, C Cravetto, G Molino, G Belforte, B Bona	Gastroenterology	1987
Membrane Transport Processes in Organized Systems TE Andreoli, JF Hoffman, DD Fanestil, SG Schultz		1987
Lipoproteins and Atherosclerosis CL Malmendier, P Alaupovic		1987
Intestinal involvement in progressive systemic sclerosis detected by increased unconjugated serum bile acids F Stellaard, T Sauerbruch, CH Luderschmidt, B Leisner, G Paumgartner	Gut	1987
Clinical Research in Gastroenterology 1 S Matern		1987
Steady-state kinetics of serum bile acids in healthy human subjects: single and dual isotope techniques using stable isotopes and mass spectrometry GT Everson	Journal of lipid research	1987
Simulation of the metabolism and enterohepatic circulation of endogenous chenodeoxycholic acid in man using a physiological pharmacokinetic model G Molino, AF Hofmann, C Cravetto, G Belforte, B Bona	European Journal of Clinical Investigation	1986
Peroxisomal dysfunction in a boy with neurologic symptoms and amaurosis (Leber disease): Clinical and biochemical findings similar to those observed in Zellweger syndrome J Ek, BF Kase, A Reith, I Björkhem, JI Pedersen	The Journal of Pediatrics	1986
Absence of bile acid malabsorption as a late effect of pelvic irradiation JJ Schuster, JA Stryker, LM Demers, R Mortel	International journal of radiation oncology, biology, physics	1986
In vitro formation of bile acids from di- and trihydroxy-5β-cholestanoic acid in human liver peroxisomes BF Kase, K Prydz, I Björkhem, JI Pedersen	Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism	1986
Serum bile acids G Paumgartner	Journal of Hepatology	1986
Defective peroxisomal cleavage of the C27-steroid side chain in the cerebro-hepato-renal syndrome of Zellweger BF Kase, I Björkhem, P Hågå, JI Pedersen	Journal of Clinical Investigation	1985
In vivo and vitro studies on formation of bile acids in patients with Zellweger syndrome. Evidence that peroxisomes are of importance in the normal biosynthesis of both cholic and chenodeoxycholic acid BF Kase, JI Pedersen, B Strandvik, I Björkhem	Journal of Clinical Investigation	1985
Portal venous bile acids in cholesterol gallstone disease: Effect of treatment with chenodeoxycholic and cholic acids K Einarsson, J Ahlberg, B Angelin, I Björkhem, S Ewerth	Hepatology	1985
Fasting and postprandial serum bile acid concentration with special reference to variations in the conjugate profile G Hedenborg, A Norman	Scandinavian Journal of Clinical & Laboratory Investigation	1985
Targeting drugs to the enterohepatic circulation: Lessons from bile acids and other endobiotics AF Hofmann	Journal of Controlled Release	1985
The diagnostic value of fasting individual serum bile acids in anicteric alcoholic liver disease: Relation to liver morphology K Einarsson, B Angelin, I Björkhem, H Glaumann	Hepatology	1985
Regulation of Hmg-coa Reductase LC Smith, AM Gotto	Regulation of Hmg-coa Reductase	1985
Serum Concentrations of Ursodeoxycholic Acid in Portal Venous and Systemic Venous Blood of Fasting Humans as Determined by Isotope Dilution—Mass Spectrometry S Euverth, B Angelin, K Einarsson, K Nilsell, I Björkhem	Gastroenterology	1985
Plasma Disappearance of 14 C-Glycocholic Acid as a Test of Liver Dysfunction K Einarsson, B Angelin, H Glaumann	Scandinavian Journal of Gastroenterology	1985
Value of serum determinations for prediction of increased ursodeoxycholic and chenodeoxycholic levels in bile F Bazzoli, H Fromm, A Roda, AK Tunuguntla, E Roda, L Barbara, P Amin	Digestive Diseases and Sciences	1985
Estimation of bile acid pool sizes from their spillover into systemic blood SD van der Werf, GP van Berge Henegouwen, W van den Broek	Journal of lipid research	1985
Mass spectrometry AL Burlingame, JO Whitney, DH Russell	Analytical Chemistry	1984
Effect of Ursodeoxycholic Acid Treatment on Intestinal Absorption of Triglycerides in Man K Einarsson, I Björkhem, R Eklöf, S Ewerth, K Nilsell, R Blomstrand	Scandinavian Journal of Gastroenterology	1984
Concentrations of Glycine- and Taurine-Conjugated Bile Acids in Portal and Systemic Venous Serum in Man K Linnet, JR Andersen, P Hesselfeldt	Scandinavian Journal of Gastroenterology	1984
Effect of chenodeoxycholic and ursodeoxycholic acids on isolated adult human hepatocytes K Miyazaki, F Nakayama, A Koga	Digestive Diseases and Sciences	1984
Systemic spill-over of bile acids GP van Berge-Henegouwen, AF Hofmann	European Journal of Clinical Investigation	1983
Mechanisms of Hepatic Electrolyte Transport BF Scharschmidt, RW Dyke	Gastroenterology	1983
(Na,K)-ATPase-mediated cation pumping in cultured rat hepatocytes. Rapid modulation by alanine and taurocholate transport and characterization of its relationship to intracellular sodium concentration RW Dyke, BF Scharschmidt	The Journal of biological chemistry	1983
Physiology of Membrane Disorders TE Andreoli, JF Hoffman, DD Fanestil		1978

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