This investigation was undertaken in order to (a) characterize the postprandial inflow of individual bile acids to the liver and (b) determine if peripheral venous bile acid levels always adequately reflect the portal venous concentration, or if saturation of hepatic bile acid uptake can occur under physiological conditions. In five patients with uncomplicated cholesterol gallstone disease, the umbilical cord was cannulated during cholecystectomy, and a catheter was left in the left portal branch for 5 to 7 d. The serum concentrations of cholic acid, chenodeoxycholic acid, and deoxycholic acid in portal venous and systemic circulation were then determined at intervals of 15 to 30 min before and after a standardized meal. A highly accurate and specific gas chromatographic/mass spectrometric technique was used.
Bo Angelin, Ingemar Björkhem, Kurt Einarsson, Staffan Ewerth
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Citations: | 1 | 5 | 3 | 9 | 12 | 7 | 10 | 5 | 5 | 4 | 9 | 11 | 2 | 1 | 1 | 4 | 3 | 1 | 5 | 2 | 2 | 1 | 3 | 1 | 1 | 2 | 1 | 3 | 3 | 2 | 5 | 3 | 4 | 2 | 5 | 5 | 8 | 5 | 11 | 4 | 3 | 1 | 175 |
Title and authors | Publication | Year |
---|---|---|
Bile acids in glucose metabolism in health and disease
H Shapiro, AA Kolodziejczyk, D Halstuch, E Elinav |
Journal of Experimental Medicine | 2018 |
Microbiome-mediated bile acid modification: Role in intestinal drug absorption and metabolism
EF Enright, BT Griffin, CG Gahan, SA Joyce |
Pharmacological research : the official journal of the Italian Pharmacological Society | 2018 |
The role of bile acids in nutritional support
G van Niekerk, T Davis, W de Villiers, AM Engelbrecht |
Critical Care | 2018 |
Circulating Fibroblast Growth Factor 19 in Portal and Systemic Blood
H Johansson, LM Mörk, M Li, AL Sandblom, I Björkhem, J Höijer, BG Ericzon, C Jorns, S Gilg, E Sparrelid, B Isaksson, G Nowak, E Ellis |
Journal of Clinical and Experimental Hepatology | 2018 |
Pharmacometabolomics Informs About Pharmacokinetic Profile of Methylphenidate
R Kaddurah-Daouk, T Hankemeier, EH Scholl, R Baillie, A Harms, C Stage, KP Dalhoff, G Jűrgens, O Taboureau, GS Nzabonimpa, AA Motsinger-Reif, R Thomsen, K Linnet, HB Rasmussen |
CPT Pharmacometrics Syst. Pharmacol. | 2018 |
Deoxycholylglycine, a conjugated secondary bile acid, reduces vascular tone by attenuating Ca 2+ sensitivity via rho kinase pathway
RN Jadeja, MC Thounaojam, M Bartoli, S Khurana |
Toxicology and Applied Pharmacology | 2018 |
Model-Based Prediction of Plasma Concentration and Enterohepatic Circulation of Total Bile Acids in Humans
B Guiastrennec, DP Sonne, M Bergstrand, T Vilsbøll, FK Knop, MO Karlsson |
CPT Pharmacometrics Syst. Pharmacol. | 2018 |
Removal of bile acids by extracorporeal therapies: an in vitro study
J Hartmann, S Harm |
The International Journal of Artificial Organs | 2018 |
Cholestatic Drug Induced Liver Injury: A Function of Bile Salt Export Pump Inhibition and Farnesoid X Receptor Antagonism
JP Jackson, KM Freeman, RL Claire, CB Black, KR Brouwer |
Applied In Vitro Toxicology | 2018 |
Asynchronous rhythms of circulating conjugated and unconjugated bile acids in the modulation of human metabolism
A Al-Khaifi, S Straniero, V Voronova, D Chernikova, V Sokolov, C Kumar, B Angelin, M Rudling |
Journal of Internal Medicine | 2018 |