Citations to this article

Absence of gamma interferon and interleukin 2 production during active visceral leishmaniasis.
E M Carvalho, … , T C Jones, W D Johnson Jr
E M Carvalho, … , T C Jones, W D Johnson Jr
Published December 1, 1985
Citation Information: J Clin Invest. 1985;76(6):2066-2069. https://doi.org/10.1172/JCI112209.
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Absence of gamma interferon and interleukin 2 production during active visceral leishmaniasis.

Abstract

The lymphocytes from eight patients with active visceral leishmaniasis (VL), a disease associated with marked immunologic dysfunction, were examined for ability to produce interleukin 2 (IL-2) and gamma interferon during in vitro cultivation. It was found that both IL-2 and gamma interferon production, in response to leishmania antigen, was absent during the active disease, but was restored after successful chemotherapy. Untreated VL patients produced IL-2 and gamma interferon when stimulated with phytohemagglutinin (PHA). Six patients with either active cutaneous or mucosal leishmaniasis, a disease not associated with immunosuppression, showed high levels of gamma interferon in response to leishmania antigen and PHA. Since IL-2 and gamma interferon have been shown to have important roles in the immune response and in the killing of leishmania, their absence may represent a key defect in the immune response in VL.

Authors

E M Carvalho, R Badaró, S G Reed, T C Jones, W D Johnson Jr

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Citations to this article in year 2006 (9)

Title and authors Publication Year
Mixed inflammatory/regulatory cytokine profile marked by simultaneous raise of interferon-? and interleukin-10 and low frequency of tumour necrosis factor-?+monocytes are hallmarks of active human visceral Leishmaniasis due to Leishmania chagasi infection
V Peruhype-Magalhães, OA Martins-Filho, A Prata, LD Silva, A Rabello, A Teixeira-Carvalho, RM Figueiredo, SF Guimarães-Carvalho, TC Ferrari, JV Weyenbergh, R Correa-Oliveira 		Clinical & Experimental Immunology 2006
The Schistosoma mansoni Hepatic Egg Granuloma Provides a Favorable Microenvironment for Sustained Growth of Leishmania donovani
MF Hassan, Y Zhang, CR Engwerda, PM Kaye, H Sharp, QD Bickle 		The American Journal of Pathology 2006
Non PC liposome entrapped promastigote antigens elicit parasite specific CD8+ and CD4+ T-cell immune response and protect hamsters against visceral leishmaniasis
SK Sharma, A Dube, A Nadeem, S Khan, I Saleem, R Garg, O Mohammad 		Vaccine 2006
Identification of a novel G245R polymorphism in the IL-2 receptor β membrane proximal domain associated with human visceral leishmaniasis
B Bucheton, L Argiro, C Chevillard, S Marquet, MM Kheir, A Mergani, SH El-Safi, AJ Dessein 		Genes and Immunity 2006
Differential effects of antigens from L. braziliensis isolates from disseminated and cutaneous leishmaniasis on in vitro cytokine production
PT Leopoldo, PR Machado, RP Almeida, A Schriefer, A Giudice, AR de Jesus, JL Ho, LH Guimarães, O Bacellar, EM Carvalho 		BMC Infectious Diseases 2006
Genes and environment in susceptibility to visceral leishmaniasis
S El-Safi, MM Kheir, B Bucheton, L Argiro, L Abel, J Dereure, JP Dedet, A Dessein 		Comptes Rendus Biologies 2006
Estudo comparativo de anticorpos IgG e IgE antileishmania como marcadores de infecção e doença em indivíduos de área endêmica de leishmaniose visceral, em São Luis, MA
MD Nascimento, GF de Bezerra, AP Neto, LM da Silva, JM Bezerra, GM de Viana 		Revista da Sociedade Brasileira de Medicina Tropical 2006
Inhibition of IL-2 Induced IL-10 Production as a Principle of Phase-Specific Immunotherapy
M Bodas, N Jain, A Awasthi, S Martin, RK Loka, D Dandekar, D Mitra, B Saha 		Journal of immunology (Baltimore, Md. : 1950) 2006
Identification of a novel G245R polymorphism in the IL-2 receptor beta membrane proximal domain associated with human visceral leishmaniasis.
Bucheton B, Argiro L, Chevillard C, Marquet S, Kheir MM, Mergani A, El-Safi SH, Dessein AJ 		Genes and immunity 2006

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