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Citations to this article

Absence of gamma interferon and interleukin 2 production during active visceral leishmaniasis.
E M Carvalho, … , T C Jones, W D Johnson Jr
E M Carvalho, … , T C Jones, W D Johnson Jr
Published December 1, 1985
Citation Information: J Clin Invest. 1985;76(6):2066-2069. https://doi.org/10.1172/JCI112209.
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Research Article Article has an altmetric score of 6

Absence of gamma interferon and interleukin 2 production during active visceral leishmaniasis.

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Abstract

The lymphocytes from eight patients with active visceral leishmaniasis (VL), a disease associated with marked immunologic dysfunction, were examined for ability to produce interleukin 2 (IL-2) and gamma interferon during in vitro cultivation. It was found that both IL-2 and gamma interferon production, in response to leishmania antigen, was absent during the active disease, but was restored after successful chemotherapy. Untreated VL patients produced IL-2 and gamma interferon when stimulated with phytohemagglutinin (PHA). Six patients with either active cutaneous or mucosal leishmaniasis, a disease not associated with immunosuppression, showed high levels of gamma interferon in response to leishmania antigen and PHA. Since IL-2 and gamma interferon have been shown to have important roles in the immune response and in the killing of leishmania, their absence may represent a key defect in the immune response in VL.

Authors

E M Carvalho, R Badaró, S G Reed, T C Jones, W D Johnson Jr

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 1989 1988 1987 1986 1973 Total
Citations: 2 2 1 1 3 2 1 5 3 8 4 7 7 6 12 7 6 5 9 9 10 6 6 5 5 9 12 5 3 5 11 19 11 10 7 7 8 8 3 2 1 253
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Citations to this article in year 2012 (6)

Title and authors Publication Year
Asiaticoside induces tumour-necrosis-factor- -mediated nitric oxide production to cure experimental visceral leishmaniasis caused by antimony-susceptible and -resistant Leishmania donovani strains
SK Bhaumik, J Paul, K Naskar, S Karmakar, T De
Journal of Antimicrobial Chemotherapy 2012
The lignan niranthin poisons Leishmania donovani topoisomerase IB and favours a Th1 immune response in mice
S Chowdhury, T Mukherjee, R Mukhopadhyay, B Mukherjee, S Sengupta, S Chattopadhyay, P Jaisankar, S Roy, HK Majumder
EMBO Molecular Medicine 2012
Immunization with Leishmania Vaccine-Alum-BCG and Montanide ISA 720 Adjuvants Induces Low-Grade Type 2 Cytokines and High Levels of IgG2 Subclass Antibodies in the Vervet Monkey ( Chlorocebus aethiops ) Model: Alum-BCG and Montanide ISA 720 Induces Robust IgG2
JM Mutiso, JC Macharia, MM Gicheru
Scandinavian Journal of Immunology 2012
Reassessment of immune correlates in human visceral leishmaniasis as defined by cytokine release in whole blood
OP Singh, K Gidwani, R Kumar, S Nylén, SL Jones, M Boelaert, D Sacks, S Sundar
Clinical and vaccine immunology : CVI 2012
Leishmania infantum chagasi in Northeastern Brazil: Asymptomatic Infection at the Urban Perimeter
NN Pontes, PV Queiroz, RD Pearson, HG Lacerda, JW Queiroz, JL Weirather, SM Jeronimo, ID Lima, DR Martins, JD Barbosa, ME Wilson
The American journal of tropical medicine and hygiene 2012
Cytokine Responses to Novel Antigens in an Indian Population Living in an Area Endemic for Visceral Leishmaniasis
OP Singh, CB Stober, AK Singh, JM Blackwell, S Sundar, EM Carvalho
PLoS neglected tropical diseases 2012

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