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Citations to this article

Absence of gamma interferon and interleukin 2 production during active visceral leishmaniasis.
E M Carvalho, … , T C Jones, W D Johnson Jr
E M Carvalho, … , T C Jones, W D Johnson Jr
Published December 1, 1985
Citation Information: J Clin Invest. 1985;76(6):2066-2069. https://doi.org/10.1172/JCI112209.
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Research Article Article has an altmetric score of 6

Absence of gamma interferon and interleukin 2 production during active visceral leishmaniasis.

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Abstract

The lymphocytes from eight patients with active visceral leishmaniasis (VL), a disease associated with marked immunologic dysfunction, were examined for ability to produce interleukin 2 (IL-2) and gamma interferon during in vitro cultivation. It was found that both IL-2 and gamma interferon production, in response to leishmania antigen, was absent during the active disease, but was restored after successful chemotherapy. Untreated VL patients produced IL-2 and gamma interferon when stimulated with phytohemagglutinin (PHA). Six patients with either active cutaneous or mucosal leishmaniasis, a disease not associated with immunosuppression, showed high levels of gamma interferon in response to leishmania antigen and PHA. Since IL-2 and gamma interferon have been shown to have important roles in the immune response and in the killing of leishmania, their absence may represent a key defect in the immune response in VL.

Authors

E M Carvalho, R Badaró, S G Reed, T C Jones, W D Johnson Jr

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Total citations by year

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Citations: 2 2 1 1 3 2 1 5 3 8 4 7 7 6 12 7 6 5 9 9 10 6 6 5 5 9 12 5 3 5 11 19 11 10 7 7 8 8 3 2 1 253
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Citations to this article in year 2010 (7)

Title and authors Publication Year
‘Active chronic visceral leishmaniasis’ in HIV-1-infected patients demonstrated by biological and clinical long-term follow-up of 10 patients
N Bourgeois, P Bastien, J Reynes, A Makinson, I Rouanet, L Lachaud
HIV Medicine 2010
Gentamicin-attenuated Leishmania infantum: cellular immunity production and protection of dogs against experimental canine leishmaniasis
H Daneshvar, MM Molaei, H Kamiabi, R Burchmore, P Hagan, RS Phillips
Parasite Immunology 2010
Plasma lipoproteins in visceral leishmaniasis and their effect onLeishmania-infected macrophages
NM Soares, TF Leal, MC Fiúza, EA Reis, MA Souza, WL Dos-Santos, L Pontes-De-Carvalho
Parasite Immunology 2010
Human immunodeficiency virus and leishmaniasis
N Ezra, MT Ochoa, N Craft
Journal of global infectious diseases 2010
Evaluation of ex vivo human immune response against candidate antigens for a visceral leishmaniasis vaccine
R Kumar, Y Goto, K Gidwani, KD Cowgill, S Sundar, SG Reed
The American journal of tropical medicine and hygiene 2010
Enhanced efficacy and immunogenicity of 78kDa antigen formulated in various adjuvants against murine visceral leishmaniasis
R Nagill, S Kaur
Vaccine 2010
A Curative Immune Profile One Week after Treatment of Indian Kala-Azar Patients Predicts Success with a Short-Course Liposomal Amphotericin B Therapy
S Mondal, P Bhattacharya, M Rahaman, N Ali, RP Goswami, P Sinnis
PLoS neglected tropical diseases 2010

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