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Citations to this article

Absence of gamma interferon and interleukin 2 production during active visceral leishmaniasis.
E M Carvalho, … , T C Jones, W D Johnson Jr
E M Carvalho, … , T C Jones, W D Johnson Jr
Published December 1, 1985
Citation Information: J Clin Invest. 1985;76(6):2066-2069. https://doi.org/10.1172/JCI112209.
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Research Article Article has an altmetric score of 6

Absence of gamma interferon and interleukin 2 production during active visceral leishmaniasis.

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Abstract

The lymphocytes from eight patients with active visceral leishmaniasis (VL), a disease associated with marked immunologic dysfunction, were examined for ability to produce interleukin 2 (IL-2) and gamma interferon during in vitro cultivation. It was found that both IL-2 and gamma interferon production, in response to leishmania antigen, was absent during the active disease, but was restored after successful chemotherapy. Untreated VL patients produced IL-2 and gamma interferon when stimulated with phytohemagglutinin (PHA). Six patients with either active cutaneous or mucosal leishmaniasis, a disease not associated with immunosuppression, showed high levels of gamma interferon in response to leishmania antigen and PHA. Since IL-2 and gamma interferon have been shown to have important roles in the immune response and in the killing of leishmania, their absence may represent a key defect in the immune response in VL.

Authors

E M Carvalho, R Badaró, S G Reed, T C Jones, W D Johnson Jr

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Citations to this article in year 2011 (12)

Title and authors Publication Year
Role of leptin in human visceral leishmaniasis?
A Dayakar, S Chandrasekaran, J Veronica, R Maurya
Medical Hypotheses 2011
Efficacy of Leishmania donovani ribosomal P1 gene as DNA vaccine in experimental visceral leishmaniasis
S Masih, SK Arora, RK Vasishta
Experimental Parasitology 2011
Advances in Immunology
E Pinaud, M Marquet, R Fiancette, S Péron, C Vincent-Fabert, Y Denizot, M Cogné
Advances in Immunology Volume 110 2011
Advances in Parasitology
H Huang
Chagas Disease, Part A 2011
New challenges in the epidemiology and treatment of visceral leishmaniasis in periurban areas
KM Dupnik, EL Nascimento, JF Rodrigues-Neto, T Keesen, MZ Fernandes, I Duarte, SM Jeronimo
Drug Development Research 2011
Nonviral Infections
VA Alves, E Abdalla
Practical Hepatic Pathology A Diagnostic Approach 2011
In silico predicted epitopes from the COOH-terminal extension of cysteine proteinase B inducing distinct immune responses during Leishmania (Leishmania) amazonensis experimental murine infection
BA Pereira, FS Silva, KM Rebello, M Marín-Villa, YM Traub-Cseko, TC Andrade, ÁL Bertho, ER Caffarena, CR Alves
BMC Immunology 2011
Interferon-Gamma Release Assay (Modified QuantiFERON) as a Potential Marker of Infection for Leishmania donovani, a Proof of Concept Study
K Gidwani, S Jones, R Kumar, M Boelaert, S Sundar, PA Bates
PLoS neglected tropical diseases 2011
Evidence That Lipopolisaccharide May Contribute to the Cytokine Storm and Cellular Activation in Patients with Visceral Leishmaniasis
JR Santos-Oliveira, EG Regis, CR Leal, RV Cunha, PT Bozza, AM Da-Cruz, EM Carvalho
PLoS neglected tropical diseases 2011
Th1/Th2 Cytokine Profile in Patients Coinfected with HIV and Leishmania in Brazil
MZ Rodrigues, MF Grassi, S Mehta, XQ Zhang, LL Gois, RT Schooley, R Badaro
Clinical and vaccine immunology : CVI 2011
KSAC, the First Defined Polyprotein Vaccine Candidate for Visceral Leishmaniasis
Y Goto, A Bhatia, VS Raman, H Liang, R Mohamath, AF Picone, SE Vidal, TS Vedvick, RF Howard, SG Reed
Clinical and vaccine immunology : CVI 2011
Control of Innate and Adaptive Immune Responses during Infectious Diseases
J Aliberti
2011

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