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Citations to this article

Absence of gamma interferon and interleukin 2 production during active visceral leishmaniasis.
E M Carvalho, … , T C Jones, W D Johnson Jr
E M Carvalho, … , T C Jones, W D Johnson Jr
Published December 1, 1985
Citation Information: J Clin Invest. 1985;76(6):2066-2069. https://doi.org/10.1172/JCI112209.
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Research Article Article has an altmetric score of 6

Absence of gamma interferon and interleukin 2 production during active visceral leishmaniasis.

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Abstract

The lymphocytes from eight patients with active visceral leishmaniasis (VL), a disease associated with marked immunologic dysfunction, were examined for ability to produce interleukin 2 (IL-2) and gamma interferon during in vitro cultivation. It was found that both IL-2 and gamma interferon production, in response to leishmania antigen, was absent during the active disease, but was restored after successful chemotherapy. Untreated VL patients produced IL-2 and gamma interferon when stimulated with phytohemagglutinin (PHA). Six patients with either active cutaneous or mucosal leishmaniasis, a disease not associated with immunosuppression, showed high levels of gamma interferon in response to leishmania antigen and PHA. Since IL-2 and gamma interferon have been shown to have important roles in the immune response and in the killing of leishmania, their absence may represent a key defect in the immune response in VL.

Authors

E M Carvalho, R Badaró, S G Reed, T C Jones, W D Johnson Jr

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Total citations by year

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Citations: 2 2 1 1 3 2 1 5 3 8 4 7 7 6 12 7 6 5 9 9 10 6 6 5 5 9 12 5 3 5 11 19 11 10 7 7 8 8 3 2 1 253
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Citations to this article in year 2016 (8)

Title and authors Publication Year
Role of pro-inflammatory cytokine IL-17 in Leishmania pathogenesis and in protective immunity by Leishmania vaccines
A Banerjee, P Bhattacharya, AB Joshi, N Ismail, R Dey, HL Nakhasi
Cellular Immunology 2016
Immunomodulation mediated through Leishmania donovani protein disulfide isomerase by eliciting CD8+ T-cell in cured visceral leishmaniasis subjects and identification of its possible HLA class-1 restricted T-cell epitopes
A Amit, MR Dikhit, V Mahantesh, R Chaudhary, AK Singh, A Singh, SK Singh, VN Das, K Pandey, V Ali, S Narayan, GC Sahoo, P Das, S Bimal
Journal of Biomolecular Structure and Dynamics 2016
Clinical, hematological and biochemical alterations in hamster (Mesocricetus auratus) experimentally infected with Leishmania infantum through different routes of inoculation
ND Moreira, J Vitoriano-Souza, BM Roatt, PM de Vieira, W Coura-Vital, JM de Cardoso, MT Rezende, HG Ker, RC Giunchetti, CM Carneiro, AB Reis
Parasites & vectors 2016
Optimizing Immunization Strategies for the Induction of Antigen-Specific CD4 and CD8 T Cell Responses for Protection against Intracellular Parasites
KA Hofmeyer, MS Duthie, JD Laurance, MA Favila, NV Hoeven, RN Coler, SG Reed, DL Burns
Clinical and vaccine immunology : CVI 2016
A Subset of Neutrophils Expressing Markers of Antigen-Presenting Cells in Human Visceral Leishmaniasis
S Sharma, RE Davis, S Srivastva, S Nylén, S Sundar, ME Wilson
The Journal of Infectious Diseases 2016
Live Attenuated Leishmania donovani Centrin Knock Out Parasites Generate Non-inferior Protective Immune Response in Aged Mice against Visceral Leishmaniasis
P Bhattacharya, R Dey, PK Dagur, AB Joshi, N Ismail, S Gannavaram, A Debrabant, AD Akue, MA KuKuruga, A Selvapandiyan, JP McCoy, HL Nakhasi, CR Engwerda
PLoS neglected tropical diseases 2016
Kala Azar in South Asia
E Noiri, TK Jha
Kala Azar in South Asia 2016
Evaluation of the antileishmanial potency, toxicity and phytochemical constituents of methanol bark extract of Sterculia villosa
A Das, MC Das, N Das, S Bhattacharjee
Pharmaceutical Biology 2016

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