Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Pancreatic Cancer (Jul 2025)
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Aging decreases the capacity of human skin to produce vitamin D3.
J MacLaughlin, M F Holick
J MacLaughlin, M F Holick
Published October 1, 1985
Citation Information: J Clin Invest. 1985;76(4):1536-1538. https://doi.org/10.1172/JCI112134.
View: Text | PDF
Research Article Article has an altmetric score of 135

Aging decreases the capacity of human skin to produce vitamin D3.

  • Text
  • PDF
Abstract

An evaluation of surgically obtained skin (age range, 8-92 yr) revealed that there is an age-dependent decrease in the epidermal concentrations of provitamin D3 (7-dehydrocholesterol). To ascertain that aging indeed decreased the capacity of human skin to produce vitamin D3, some of the skin samples were exposed to ultraviolet radiation and the content of previtamin D3 was determined in the epidermis and dermis. The epidermis in the young and older subjects was the major site for the formation of previtamin D3, accounting for greater than 80% of the total previtamin D3 that was produced in the skin. A comparison of the amount of previtamin D3 produced in the skin from the 8- and 18-yr-old subjects with the amount produced in the skin from the 77- and 82-yr-old subjects revealed that aging can decrease by greater than twofold the capacity of the skin to produce previtamin D3. Recognition of this difference may be extremely important for the elderly, who infrequently expose a small area of skin to sunlight and who depend on this exposure for their vitamin D nutritional needs.

Authors

J MacLaughlin, M F Holick

×

Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 1989 1988 1987 1986 1985 1981 1971 Total
Citations: 7 25 14 29 43 60 33 38 49 47 50 47 57 40 49 47 42 30 28 32 25 14 15 11 7 11 15 10 15 2 7 5 10 4 4 7 11 5 4 2 1 1 1 954
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2021 (43)

Title and authors Publication Year
The Interdependency and Co-Regulation of the Vitamin D and Cholesterol Metabolism
T Warren, R McAllister, A Morgan, TS Rai, V McGilligan, M Ennis, C Page, C Kelly, A Peace, BM Corfe, MM Auley, S Watterson
Cells 2021
Non-Musculoskeletal Benefits of Vitamin D beyond the Musculoskeletal System
S Zhang, DD Miller, W Li
International journal of molecular sciences 2021
Vitamin D and cardiovascular health
F de la Guía-Galipienso, M Martínez-Ferran, N Vallecillo, CJ Lavie, F Sanchis-Gomar, H Pareja-Galeano
Clinical nutrition (Edinburgh, Scotland) 2021
The Impact of Vitamin D on Skin Aging
G Bocheva, RM Slominski, AT Slominski
International journal of molecular sciences 2021
Older Adults Who Spend More Time Outdoors in Summer and Have Higher Dietary Vitamin D Than Younger Adults Can Present at Least as High Vitamin D Status: A Pilot Study
O Borecka, MD Farrar, JE Osman, LE Rhodes, AR Webb
International journal of environmental research and public health 2021
Vitamin D toxicity related to its physiological and unphysiological supply
DR Fraser
Trends in endocrinology and metabolism: TEM 2021
Vitamin D and Obesity: Current Evidence and Controversies
I Karampela, A Sakelliou, N Vallianou, GS Christodoulatos, F Magkos, M Dalamaga
Current Obesity Reports 2021
Vitamin D Resistance as a Possible Cause of Autoimmune Diseases: A Hypothesis Confirmed by a Therapeutic High-Dose Vitamin D Protocol
D Lemke, RJ Klement, F Schweiger, B Schweiger, J Spitz
Frontiers in immunology 2021
Low Vitamin D Status at Admission as a Risk Factor for Poor Survival in Hospitalized Patients With COVID-19: An Italian Retrospective Study
M Infante, A Buoso, M Pieri, S Lupisella, M Nuccetelli, S Bernardini, A Fabbri, M Iannetta, M Andreoni, V Colizzi, M Morello
Journal of the American College of Nutrition 2021
Changes in vitamin D levels and depressive symptoms in later life in England
GD Gessa, JP Biddulph, P Zaninotto, C de Oliveira
Scientific Reports 2021
Vitamin D and its therapeutic relevance in pulmonary diseases
S Ahmad, S Arora, S Khan, M Mohsin, A Mohan, K Manda, MA Syed
The Journal of Nutritional Biochemistry 2021
Vitamin D Deficiency is Associated with Handgrip Strength, Nutritional Status and T2DM in Community-Dwelling Older Mexican Women: A Cross-Sectional Study
L Mendoza-Garcés, MC Velázquez-Alva, MF Cabrer-Rosales, I Arrieta-Cruz, R Gutiérrez-Juárez, ME Irigoyen-Camacho
Nutrients 2021
Is the shielding effect of cholecalciferol in SARS CoV-2 infection dependable? An evidence based unraveling
SL Basha, S Suresh, VV Reddy, SP Teja
Clinical Epidemiology and Global Health 2021
Serum Calcium and Vitamin D levels: Correlation with severity of COVID-19 in hospitalized patients in Royal Hospital, Oman
W Osman, FA Fahdi, IA Salmi, HA Khalili, A Gokhale, F Khamis
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 2021
Does solar ultraviolet radiation play a role in COVID-19 infection and deaths? An environmental ecological study in Italy
G Isaia, H Diémoz, F Maluta, I Fountoulakis, D Ceccon, A di Sarra, S Facta, F Fedele, G Lorenzetto, AM Siani, G Isaia
The Science of The Total Environment 2021
The role of vitamin D in reducing SARS-CoV-2 infection: An update
MS Alam, DM Czajkowsky, A Islam, A Rahman
International Immunopharmacology 2021
Vitamin D deficiency and insufficiency in Hawaii: Levels and sources of serum vitamin D in older adults
CE Oshiro, TA Hillier, G Edmonds, M Peterson, PL Hill, S Hampson
American Journal of Human Biology 2021
Physical Determinants of Vitamin D Photosynthesis: A Review
JJ Neville, T Palmieri, AR Young
JBMR Plus 2021
Uptake of Vitamins D2, D3, D4, D5, D6, and D7 Solubilized in Mixed Micelles by Human Intestinal Cells, Caco-2, an Enhancing Effect of Lysophosphatidylcholine on the Cellular Uptake, and Estimation of Vitamins D’ Biological Activities
E Kotake-Nara, S Komba, M Hase
Nutrients 2021
Decrease in serum calcitriol (but not free 25-hydroxyvitamin D) concentration in hip fracture healing
J Vaculik, L Wenchich, M Bobelyak, K Pavelka, JJ Stepan
Journal of Endocrinological Investigation 2021
Risk Factors Associated with Vitamin D Status among Older Puerto Rican Adults
OJ Akinlawon, CQ Lai, SE Noel, KD Flanagan, KL Tucker
The Journal of nutrition 2021
Vitamin D levels and mortality with SARS-COV-2 infection: a retrospective two-centre cohort study
M Zafar, M Karkhanis, M Shahbaz, A Khanna, L Barry, S Alam, K Lawrence, B Pun, R Eldebri, O Makanjuola, D Safarova, M Farooq, H Nooredinavand, F Cuison, K Subba, RS Randhawa, J Hegner, O Oluwamayowa, A Elyasaky, B Adekunle, M Periasamy, M Abdelbagi, Z Maryam, B Khuu, AE Morete, G Ciroi, S Moran, W O'Neill, MJ Zafar, N Zafar, M Patel, R Golez, A Hadid, T Muhammad, P Mayhead, M Whitehead, U Dashora
Postgraduate medical journal 2021
COVID-19 and nutritional deficiency: a review of existing knowledge
MM Pallath, AK Ahirwar, SC Tripathi, P Asia, A Sakarde, N Gopal
Hormone Molecular Biology and Clinical Investigation 2021
Vitamin D status in Mainland of China: A systematic review and meta-analysis
W Liu, J Hu, Y Fang, P Wang, Y Lu, N Shen
2021
Low vitamin D levels and the long‐term functional outcome of stroke up to 5 years
YY Zeng, CX Yuan, MX Wu, L Cheng, SN Zhou, P Hu, KL Fan, WJ Tang, JC He
Brain and Behavior 2021
Effects of Monthly Intramuscular High-Dose Vitamin D2 on Serum 25-Hydroxyvitamin D and Immune Parameters in Very Elderly Chinese Patients with Vitamin D Deficiency
P Bian, X Jin, Z Shou, FR Perez-Lopez
International Journal of Endocrinology 2021
The Omic Insights on Unfolding Saga of COVID-19
A Kaur, M Chopra, M Bhushan, S Gupta, HK P, N Sivagurunathan, N Shukla, S Rajagopal, P Bhalothia, P Sharma, J Naravula, R Suravajhala, A Gupta, BA Abbasi, P Goswami, H Singh, R Narang, R Polavarapu, KM Medicherla, J Valadi, AK S, G Chaubey, KK Singh, OR Bandapalli, PB Kishor, P Suravajhala
Frontiers in immunology 2021
Population Vitamin D Stores Are Increasing in Tasmania, and This Is Associated With Less BMD Loss Over 10 Years
M Thompson, D Aitken, S Balogun, F Cicuttini, G Jones
The Journal of clinical endocrinology and metabolism 2021
Association between vitamin D status and long‐term falls‐related hospitalization risk in older women
M Sim, K Zhu, JR Lewis, JM Hodgson, RL Prince
Journal of the American Geriatrics Society 2021
Hypovitaminosis D and the endocrine phenotype of COVID-19
A Giustina
Endocrine 2021
CORRELATION OF VITAMIN D LEVELS WITH HIP FRACTURES IN PATIENTS ABOVE THE AGE OF SIXTY YEARS – A CLINICAL STUDY
R Kapila, K Arora, S Kapila, AK Batta, A Kamat, G Singh
2021
Association between deficient and insufficient 25(OH)D serum concentrations and cardiometabolic risk factors: Findings of a population-based study with older adults of southern Brazil
F Cembranel, AC Boing, AF Boing, AJ Xavier, E d'Orsi
Preventive Medicine Reports 2021
Cutaneous concentrations of 7‐dehydrocholesterol in Hoffmann's two‐toed sloths ( Choloepus hoffmanni ) in managed care
IA Jimenez, AJ Makowski, LM Scanlon, SE ChildsSanford
Zoo Biology 2021
In COVID-19 patients, low 25-hydroxyvitamin D level in serum is associated with longer viral clearance time and higher risk of intensive care unit admission
J Al-Salman, S Alghareeb, E Alarab, H Jahrami, WB Grant
Nutrition & Food Science 2021
Estimations of the Erythemal UV Doses and the Amount of the Sun-Synthesized Vitamin D by Adults during the Cruise to Spitsbergen–Polar Measurement Campaign (2–21 July 2017)
A Czerwińska, W Czuchraj
Atmosphere 2021
To the question of the pathogenetic mechanisms of the influence of obesity on the level of vitamin D
LA Suplotova, VA Avdeeva, LY Rozhinskaya
Obesity and metabolism 2021
100 YEARS OF VITAMIN D: Dose–response for change in 25-hydroxyvitamin D after UV exposure: outcome of a systematic review
AR Webb, R Alghamdi, R Kift, LE Rhodes
Endocrine Connections 2021
[Nutrient Status of Vitamin D among Cancer Patients]
Zhijun Li, Jing Shi, Zengliang Wang, Haisheng Chen, Yuguo Liu
Zhongguo fei ai za zhi = Chinese journal of lung cancer 2021
The Safe and Effective Use of Plant-Based Diets with Guidelines for Health Professionals
WJ Craig, AR Mangels, U Fresán, K Marsh, FL Miles, AV Saunders, EH Haddad, CE Heskey, P Johnston, E Larson-Meyer, M Orlich
Nutrients 2021
Vitamin D Status of the British African-Caribbean Residents: Analysis of the UK Biobank Cohort
RM Vearing, KH Hart, K Charlton, Y Probst, DJ Blackbourn, KR Ahmadi, SA Lanham-New, AL Darling
Nutrients 2021
Association of lockdowns with the protective role of ultraviolet-B (UVB) radiation in reducing COVID-19 deaths
RK Moozhipurath, L Kraft
Scientific Reports 2021
Association between deficient and insufficient 25(OH)D serum concentrations and cardiometabolic risk factors: Findings of a population-based study with older adults of southern Brazil.
Cembranel F, Boing AC, Boing AF, Xavier AJ, d'Orsi E
Preventive Medicine Reports 2021
Vitamin D Deficiency Is a Predictor of Mortality in Elderly with Chronic Heart Failure.
Yılmaz Öztekin GM, Genç A, Arslan Ş
2021

← Previous 1 2 Next →

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Picked up by 5 news outlets
Referenced in 5 policy sources
Posted by 88 X users
Referenced in 3 patents
On 4 Facebook pages
On 6 videos
Referenced in 3 clinical guideline sources
561 readers on Mendeley
See more details