An evaluation of surgically obtained skin (age range, 8-92 yr) revealed that there is an age-dependent decrease in the epidermal concentrations of provitamin D3 (7-dehydrocholesterol). To ascertain that aging indeed decreased the capacity of human skin to produce vitamin D3, some of the skin samples were exposed to ultraviolet radiation and the content of previtamin D3 was determined in the epidermis and dermis. The epidermis in the young and older subjects was the major site for the formation of previtamin D3, accounting for greater than 80% of the total previtamin D3 that was produced in the skin. A comparison of the amount of previtamin D3 produced in the skin from the 8- and 18-yr-old subjects with the amount produced in the skin from the 77- and 82-yr-old subjects revealed that aging can decrease by greater than twofold the capacity of the skin to produce previtamin D3. Recognition of this difference may be extremely important for the elderly, who infrequently expose a small area of skin to sunlight and who depend on this exposure for their vitamin D nutritional needs.
J MacLaughlin, M F Holick
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Citations: | 7 | 25 | 14 | 29 | 43 | 60 | 33 | 38 | 49 | 47 | 50 | 47 | 57 | 40 | 49 | 47 | 42 | 30 | 28 | 32 | 25 | 14 | 15 | 11 | 7 | 11 | 15 | 10 | 15 | 2 | 7 | 5 | 10 | 4 | 4 | 7 | 11 | 5 | 4 | 2 | 1 | 1 | 1 | 954 |
Title and authors | Publication | Year |
---|---|---|
The Interdependency and Co-Regulation of the Vitamin D and Cholesterol Metabolism
T Warren, R McAllister, A Morgan, TS Rai, V McGilligan, M Ennis, C Page, C Kelly, A Peace, BM Corfe, MM Auley, S Watterson |
Cells | 2021 |
Non-Musculoskeletal Benefits of Vitamin D beyond the Musculoskeletal System
S Zhang, DD Miller, W Li |
International journal of molecular sciences | 2021 |
Vitamin D and cardiovascular health
F de la Guía-Galipienso, M Martínez-Ferran, N Vallecillo, CJ Lavie, F Sanchis-Gomar, H Pareja-Galeano |
Clinical nutrition (Edinburgh, Scotland) | 2021 |
The Impact of Vitamin D on Skin Aging
G Bocheva, RM Slominski, AT Slominski |
International journal of molecular sciences | 2021 |
Older Adults Who Spend More Time Outdoors in Summer and Have Higher Dietary Vitamin D Than Younger Adults Can Present at Least as High Vitamin D Status: A Pilot Study
O Borecka, MD Farrar, JE Osman, LE Rhodes, AR Webb |
International journal of environmental research and public health | 2021 |
Vitamin D toxicity related to its physiological and unphysiological supply
DR Fraser |
Trends in endocrinology and metabolism: TEM | 2021 |
Vitamin D and Obesity: Current Evidence and Controversies
I Karampela, A Sakelliou, N Vallianou, GS Christodoulatos, F Magkos, M Dalamaga |
Current Obesity Reports | 2021 |
Vitamin D Resistance as a Possible Cause of Autoimmune Diseases: A Hypothesis Confirmed by a Therapeutic High-Dose Vitamin D Protocol
D Lemke, RJ Klement, F Schweiger, B Schweiger, J Spitz |
Frontiers in immunology | 2021 |
Low Vitamin D Status at Admission as a Risk Factor for Poor Survival in Hospitalized Patients With COVID-19: An Italian Retrospective Study
M Infante, A Buoso, M Pieri, S Lupisella, M Nuccetelli, S Bernardini, A Fabbri, M Iannetta, M Andreoni, V Colizzi, M Morello |
Journal of the American College of Nutrition | 2021 |
Changes in vitamin D levels and depressive symptoms in later life in England
GD Gessa, JP Biddulph, P Zaninotto, C de Oliveira |
Scientific Reports | 2021 |
Vitamin D and its therapeutic relevance in pulmonary diseases
S Ahmad, S Arora, S Khan, M Mohsin, A Mohan, K Manda, MA Syed |
The Journal of Nutritional Biochemistry | 2021 |
Vitamin D Deficiency is Associated with Handgrip Strength, Nutritional Status and T2DM in Community-Dwelling Older Mexican Women: A Cross-Sectional Study
L Mendoza-Garcés, MC Velázquez-Alva, MF Cabrer-Rosales, I Arrieta-Cruz, R Gutiérrez-Juárez, ME Irigoyen-Camacho |
Nutrients | 2021 |
Is the shielding effect of cholecalciferol in SARS CoV-2 infection dependable? An evidence based unraveling
SL Basha, S Suresh, VV Reddy, SP Teja |
Clinical Epidemiology and Global Health | 2021 |
Serum Calcium and Vitamin D levels: Correlation with severity of COVID-19 in hospitalized patients in Royal Hospital, Oman
W Osman, FA Fahdi, IA Salmi, HA Khalili, A Gokhale, F Khamis |
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases | 2021 |
Does solar ultraviolet radiation play a role in COVID-19 infection and deaths? An environmental ecological study in Italy
G Isaia, H Diémoz, F Maluta, I Fountoulakis, D Ceccon, A di Sarra, S Facta, F Fedele, G Lorenzetto, AM Siani, G Isaia |
The Science of The Total Environment | 2021 |
The role of vitamin D in reducing SARS-CoV-2 infection: An update
MS Alam, DM Czajkowsky, A Islam, A Rahman |
International Immunopharmacology | 2021 |
Vitamin D deficiency and insufficiency in Hawaii: Levels and sources of serum vitamin D in older adults
CE Oshiro, TA Hillier, G Edmonds, M Peterson, PL Hill, S Hampson |
American Journal of Human Biology | 2021 |
Physical Determinants of Vitamin D Photosynthesis: A Review
JJ Neville, T Palmieri, AR Young |
JBMR Plus | 2021 |
Uptake of Vitamins D2, D3, D4, D5, D6, and D7 Solubilized in Mixed Micelles by Human Intestinal Cells, Caco-2, an Enhancing Effect of Lysophosphatidylcholine on the Cellular Uptake, and Estimation of Vitamins D’ Biological Activities
E Kotake-Nara, S Komba, M Hase |
Nutrients | 2021 |
Decrease in serum calcitriol (but not free 25-hydroxyvitamin D) concentration in hip fracture healing
J Vaculik, L Wenchich, M Bobelyak, K Pavelka, JJ Stepan |
Journal of Endocrinological Investigation | 2021 |
Risk Factors Associated with Vitamin D Status among Older Puerto Rican Adults
OJ Akinlawon, CQ Lai, SE Noel, KD Flanagan, KL Tucker |
The Journal of nutrition | 2021 |
Vitamin D levels and mortality with SARS-COV-2 infection: a retrospective two-centre cohort study
M Zafar, M Karkhanis, M Shahbaz, A Khanna, L Barry, S Alam, K Lawrence, B Pun, R Eldebri, O Makanjuola, D Safarova, M Farooq, H Nooredinavand, F Cuison, K Subba, RS Randhawa, J Hegner, O Oluwamayowa, A Elyasaky, B Adekunle, M Periasamy, M Abdelbagi, Z Maryam, B Khuu, AE Morete, G Ciroi, S Moran, W O'Neill, MJ Zafar, N Zafar, M Patel, R Golez, A Hadid, T Muhammad, P Mayhead, M Whitehead, U Dashora |
Postgraduate medical journal | 2021 |
COVID-19 and nutritional deficiency: a review of existing knowledge
MM Pallath, AK Ahirwar, SC Tripathi, P Asia, A Sakarde, N Gopal |
Hormone Molecular Biology and Clinical Investigation | 2021 |
Vitamin D status in Mainland of China: A systematic review and meta-analysis
W Liu, J Hu, Y Fang, P Wang, Y Lu, N Shen |
2021 | |
Low vitamin D levels and the long‐term functional outcome of stroke up to 5 years
YY Zeng, CX Yuan, MX Wu, L Cheng, SN Zhou, P Hu, KL Fan, WJ Tang, JC He |
Brain and Behavior | 2021 |
Effects of Monthly Intramuscular High-Dose Vitamin D2 on Serum 25-Hydroxyvitamin D and Immune Parameters in Very Elderly Chinese Patients with Vitamin D Deficiency
P Bian, X Jin, Z Shou, FR Perez-Lopez |
International Journal of Endocrinology | 2021 |
The Omic Insights on Unfolding Saga of COVID-19
A Kaur, M Chopra, M Bhushan, S Gupta, HK P, N Sivagurunathan, N Shukla, S Rajagopal, P Bhalothia, P Sharma, J Naravula, R Suravajhala, A Gupta, BA Abbasi, P Goswami, H Singh, R Narang, R Polavarapu, KM Medicherla, J Valadi, AK S, G Chaubey, KK Singh, OR Bandapalli, PB Kishor, P Suravajhala |
Frontiers in immunology | 2021 |
Population Vitamin D Stores Are Increasing in Tasmania, and This Is Associated With Less BMD Loss Over 10 Years
M Thompson, D Aitken, S Balogun, F Cicuttini, G Jones |
The Journal of clinical endocrinology and metabolism | 2021 |
Association between vitamin D status and long‐term falls‐related hospitalization risk in older women
M Sim, K Zhu, JR Lewis, JM Hodgson, RL Prince |
Journal of the American Geriatrics Society | 2021 |
Hypovitaminosis D and the endocrine phenotype of COVID-19
A Giustina |
Endocrine | 2021 |
CORRELATION OF VITAMIN D LEVELS WITH HIP FRACTURES IN PATIENTS ABOVE THE AGE OF SIXTY YEARS – A CLINICAL STUDY
R Kapila, K Arora, S Kapila, AK Batta, A Kamat, G Singh |
2021 | |
Association between deficient and insufficient 25(OH)D serum concentrations and cardiometabolic risk factors: Findings of a population-based study with older adults of southern Brazil
F Cembranel, AC Boing, AF Boing, AJ Xavier, E d'Orsi |
Preventive Medicine Reports | 2021 |
Cutaneous concentrations of 7‐dehydrocholesterol in Hoffmann's two‐toed sloths ( Choloepus hoffmanni ) in managed care
IA Jimenez, AJ Makowski, LM Scanlon, SE ChildsSanford |
Zoo Biology | 2021 |
In COVID-19 patients, low 25-hydroxyvitamin D level in serum is associated with longer viral clearance time and higher risk of intensive care unit admission
J Al-Salman, S Alghareeb, E Alarab, H Jahrami, WB Grant |
Nutrition & Food Science | 2021 |
Estimations of the Erythemal UV Doses and the Amount of the Sun-Synthesized Vitamin D by Adults during the Cruise to Spitsbergen–Polar Measurement Campaign (2–21 July 2017)
A Czerwińska, W Czuchraj |
Atmosphere | 2021 |
To the question of the pathogenetic mechanisms of the influence of obesity on the level of vitamin D
LA Suplotova, VA Avdeeva, LY Rozhinskaya |
Obesity and metabolism | 2021 |
100 YEARS OF VITAMIN D: Dose–response for change in 25-hydroxyvitamin D after UV exposure: outcome of a systematic review
AR Webb, R Alghamdi, R Kift, LE Rhodes |
Endocrine Connections | 2021 |
[Nutrient Status of Vitamin D among Cancer Patients]
Zhijun Li, Jing Shi, Zengliang Wang, Haisheng Chen, Yuguo Liu |
Zhongguo fei ai za zhi = Chinese journal of lung cancer | 2021 |
The Safe and Effective Use of Plant-Based Diets with Guidelines for Health Professionals
WJ Craig, AR Mangels, U Fresán, K Marsh, FL Miles, AV Saunders, EH Haddad, CE Heskey, P Johnston, E Larson-Meyer, M Orlich |
Nutrients | 2021 |
Vitamin D Status of the British African-Caribbean Residents: Analysis of the UK Biobank Cohort
RM Vearing, KH Hart, K Charlton, Y Probst, DJ Blackbourn, KR Ahmadi, SA Lanham-New, AL Darling |
Nutrients | 2021 |
Association of lockdowns with the protective role of ultraviolet-B (UVB) radiation in reducing COVID-19 deaths
RK Moozhipurath, L Kraft |
Scientific Reports | 2021 |
Association between deficient and insufficient 25(OH)D serum concentrations and cardiometabolic risk factors: Findings of a population-based study with older adults of southern Brazil.
Cembranel F, Boing AC, Boing AF, Xavier AJ, d'Orsi E |
Preventive Medicine Reports | 2021 |
Vitamin D Deficiency Is a Predictor of Mortality in Elderly with Chronic Heart Failure.
Yılmaz Öztekin GM, Genç A, Arslan Ş |
2021 |