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Citations to this article

Aging decreases the capacity of human skin to produce vitamin D3.
J MacLaughlin, M F Holick
J MacLaughlin, M F Holick
Published October 1, 1985
Citation Information: J Clin Invest. 1985;76(4):1536-1538. https://doi.org/10.1172/JCI112134.
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Research Article Article has an altmetric score of 135

Aging decreases the capacity of human skin to produce vitamin D3.

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Abstract

An evaluation of surgically obtained skin (age range, 8-92 yr) revealed that there is an age-dependent decrease in the epidermal concentrations of provitamin D3 (7-dehydrocholesterol). To ascertain that aging indeed decreased the capacity of human skin to produce vitamin D3, some of the skin samples were exposed to ultraviolet radiation and the content of previtamin D3 was determined in the epidermis and dermis. The epidermis in the young and older subjects was the major site for the formation of previtamin D3, accounting for greater than 80% of the total previtamin D3 that was produced in the skin. A comparison of the amount of previtamin D3 produced in the skin from the 8- and 18-yr-old subjects with the amount produced in the skin from the 77- and 82-yr-old subjects revealed that aging can decrease by greater than twofold the capacity of the skin to produce previtamin D3. Recognition of this difference may be extremely important for the elderly, who infrequently expose a small area of skin to sunlight and who depend on this exposure for their vitamin D nutritional needs.

Authors

J MacLaughlin, M F Holick

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 1989 1988 1987 1986 1985 1981 1971 Total
Citations: 6 25 14 29 43 60 33 38 49 47 50 47 57 40 49 47 42 30 28 32 25 14 15 11 7 11 15 10 15 2 7 5 10 4 4 7 11 5 4 2 1 1 1 953
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2016 (47)

Title and authors Publication Year
Vitamin D, reactive oxygen species and calcium signalling in ageing and disease
MJ Berridge
Philosophical Transactions of the Royal Society B: Biological Sciences 2016
Association of low levels of vitamin D with chronic stable angina: A prospective case-control study
AH Raina, MS Allai, ZA Shah, KH Changal, MA Raina, FA Bhat
North American Journal of Medical Sciences 2016
Response of Vitamin D Concentration to Vitamin D 3 Administration in Older Adults without Sun Exposure: A Randomized Double-Blind Trial
JB Schwartz, L Kane, D Bikle
Journal of the American Geriatrics Society 2016
Endocrinology: Adult and Pediatric
M Gurnell, TJ Visser, P Beck-Peccoz, VK Chatterjee
Endocrinology: Adult and Pediatric 2016
Implications of the nutrition transition for vitamin D intake and status in Aboriginal groups in the Canadian Arctic
JE Fares, HA Weiler
Nutrition Reviews 2016
Osteoporosis in Older Persons
JA Cauley
Osteoporosis in Older Persons 2016
Vitamin D: not just the bone. Evidence for beneficial pleiotropic extraskeletal effects
M Caprio, M Infante, M Calanchini, C Mammi, A Fabbri
Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity 2016
Vitamin D Deficiency Strongly Predicts Adverse Medical Outcome Across Different Medical Inpatient Populations: Results From a Prospective Study
L Graedel, M Merker, S Felder, A Kutz, S Haubitz, L Faessler, M Kaeslin, A Huber, B Mueller, P Schuetz
Medicine 2016
Vitamin D status and its predictors in New Zealand aged-care residents eligible for a government-funded universal vitamin D supplementation programme
SO MacDonell, JC Miller, MJ Harper, DL Waters, LA Houghton
Public Health Nutrition 2016
Vitamin D Levels and the Risk of Cognitive Decline in Chinese Elderly People: the Chinese Longitudinal Healthy Longevity Survey
DB Matchar, CL Chei, ZX Yin, V Koh, B Chakraborty, XM Shi, Y Zeng
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2016
Weight and skin colour as predictors of vitamin D status: results of an epidemiological investigation using nationally representative data
S Rajan, T Weishaar, B Keller
Public Health Nutrition 2016
A practical approach to secondary osteoporosis – Case studies in Asia
V Lim
Osteoporosis and Sarcopenia 2016
The impact of 1-year vitamin D supplementation on vitamin D status in athletes: a dose–response study
EM Backx, M Tieland, K Maase, AK Kies, M Mensink, LJ van Loon, LC de Groot
European Journal of Clinical Nutrition 2016
Nutritional Strategies Facing an Older Demographic: The Nutrition UP 65 Study Protocol
TF Amaral, A Santos, RS Guerra, AS Sousa, L Álvares, R Valdiviesso, C Afonso, P Padrão, C Martins, G Ferro, P Moreira, N Borges
JMIR Research Protocols 2016
Vitamin D level and its association with adiposity among multi-ethnic adults in Kuala Lumpur, Malaysia: a cross sectional study
IS Shafinaz, FM Moy
BMC Public Health 2016
Serum 25(OH)D seasonality in urologic patients from central Italy
A Calgani, M Iarlori, V Rizi, G Pace, M Bologna, C Vicentini, A Angelucci
Journal of Photochemistry and Photobiology B: Biology 2016
Major inter-personal variation in the increase and maximal level of 25-hydroxy vitamin D induced by UVB
P Datta, PA Philipsen, P Olsen, B Petersen, P Johansen, N Morling, HC Wulf
Photochemical & Photobiological Sciences 2016
Worldwide cutaneous malignant melanoma incidences analyzed by sex, age, and skin type over time (1955–2007): Is HPV infection of androgenic hair follicular melanocytes a risk factor for developing melanoma exclusively in people of European-ancestry?
SJ Merrill, M Subramanian, DE Godar
Dermato-endocrinology 2016
Vitamin D and Diabetic Complications: True or False Prophet?
U Alam, V Arul-Devah, S Javed, RA Malik
Diabetes Therapy 2016
Vitamin D, Cognition and Alzheimer’s Disease: The Therapeutic Benefit is in the D-Tails
V Landel, C Annweiler, P Millet, M Morello, F Féron, D Wion
Journal of Alzheimer's disease : JAD 2016
Vitamin D deficiency as adverse drug reaction? A cross-sectional study in Dutch geriatric outpatients
AC van Orten-Luiten, A Janse, RA Dhonukshe-Rutten, RF Witkamp
European Journal of Clinical Pharmacology 2016
Determinants of vitamin D supplementation prescription in nursing homes: a survey among general practitioners
F Buckinx, JY Reginster, E Cavalier, J Petermans, C Ricour, C Dardenne, O Bruyère
Osteoporosis International 2016
Environmental and genetic determinants of vitamin D status among older adults in London, UK
DA Jolliffe, Y Hanifa, KD Witt, TR Venton, M Rowe, PM Timms, E Hyppönen, RT Walton, CJ Griffiths, AR Martineau
The Journal of Steroid Biochemistry and Molecular Biology 2016
Vitamin D status among indigenous Mayan (Kekchi) and Afro-Caribe (Garifuna) adolescents from Guatemala: a comparative description between two ethnic groups residing on the Rio Dulce at the Caribbean coast in Izabal Province, Guatemala
A Naqvi, NW Solomons, R Campos, MJ Soto-Méndez, E Caplan, L Armas, OI Bermudez
Public Health Nutrition 2016
Vitamin D and Mammographic Findings
J Riedel, L Straub, J Wissing, A Artmann, M Schmidmayr, M Kiechle, V Seifert-Klauss
Geburtshilfe und Frauenheilkunde 2016
Farming, Foreign Holidays, and Vitamin D in Orkney
E Weiss, L Zgaga, S Read, S Wild, MG Dunlop, H Campbell, R McQuillan, JF Wilson, AT Slominski
PloS one 2016
Assessment of prevalence of hypovitaminosis D in multiethnic population of the United Arab Emirates
SB Sridhar, PG Rao, SK Multani, M Jain
Journal of Advanced Pharmaceutical Technology & Research 2016
Recommendations for managing cutaneous disorders associated with advancing age
S Seite, P Humbert, B Dreno, J Krutmann, T Luger, R Triller, S Meaume
Clinical Interventions in Aging 2016
Global Consensus Recommendations on Prevention and Management of Nutritional Rickets
CF Munns, N Shaw, M Kiely, BL Specker, TD Thacher, K Ozono, T Michigami, D Tiosano, MZ Mughal, O Mäkitie, L Ramos-Abad, L Ward, LA DiMeglio, N Atapattu, H Cassinelli, C Braegger, JM Pettifor, A Seth, HW Idris, V Bhatia, J Fu, G Goldberg, L Sävendahl, R Khadgawat, P Pludowski, J Maddock, E Hyppönen, A Oduwole, E Frew, M Aguiar, T Tulchinsky, G Butler, W Högler
The Journal of clinical endocrinology and metabolism 2016
Nutritional Influences on Bone Health
CM Weaver, S Jakeman
Nutritional Influences on Bone Health 2016
Vitamin D in sarcopenia: Understanding its role in pathogenesis, prevention and treatment
G Arik, Z Ulger
European Geriatric Medicine 2016
Osteoporosis: An under-recognized public health problem: Local and global risk factors and its regional and worldwide prevalence
R Vijayakumar, D Büsselberg
Journal of Local and Global Health Science 2016
Vitamin D and cognition
H Wehr, M Bednarska-Makaruk
Postępy Psychiatrii i Neurologii 2016
Vitamin D Intake and Serum 25-Hydroxyvitamin D Levels in Korean Adults: Analysis of the 2009 Korea National Health and Nutrition Examination Survey (KNHANES IV-3) Using a Newly Established Vitamin D Database
K Yoo, J Cho, S Ly
Nutrients 2016
Prevalence of vitamin D deficiency in orthopaedic patients – A single centre study
CP Pal, H Kumar, D Kumar, V Mittal, G Deshwar, D Altaf, S Verma
Journal of Clinical Orthopaedics and Trauma 2016
Serum 25-hydroxyvitamin D levels in a healthy population from the North of Portugal
A Bettencourt, D Boleixa, J Reis, JC Oliveira, D Mendonça, PP Costa, BM da Silva, A Marinho, AM da Silva
The Journal of Steroid Biochemistry and Molecular Biology 2016
The benefits of utilising geo-mapping for visualising the vitamin D status of Dublin city and the surrounding urban districts
E Laird, T Shannon, VE Crowley, M Healy
Irish Journal of Medical Science 2016
Endocrinology
C Napier, SH Pearce
Endocrinology 2016
Association of Vitamin D Deficiency and Thyroid Function in Postmenopausal Women
M Niafar, L Pourafkari, S Aminmozaffari, ND Nader
Advanced pharmaceutical bulletin 2016
Low Prevalence of Vitamin D Insufficiency among Nepalese Infants Despite High Prevalence of Vitamin D Insufficiency among Their Mothers
J Haugen, M Ulak, R Chandyo, S Henjum, A Thorne-Lyman, P Ueland, Ø Midtun, P Shrestha, T Strand
Nutrients 2016
Correlation of objectively measured light exposure and serum vitamin D in men aged over 60 years
AJ Fields, SE Linnville, RE Hoyt
Health Psychology Open 2016
Association between Vitamin D Deficiency and Antinuclear Antibodies in Middle-Aged and Older U.S. Adults
HC Meier, DP Sandler, EM Simonsick, CG Parks
Cancer epidemiology, biomarkers & prevention 2016
Differences in the prevalence of vitamin D deficiency and hip fractures in nursing home residents and independently living elderly
A Shinkov, AM Borissova, L Dakovska, J Vlahov, L Kassabova, D Svinarov, S Krivoshiev
Archives of Endocrinology and Metabolism 2016
Association between the serum 25-hydroxyvitamin D level and allergic rhinitis in Korean children
SH Yoon, JY Kim, YH Kim, YA Park, IS Sol, MJ Kim, KW Kim, MH Sohn, KE Kim
Allergy Asthma & Respiratory Disease 2016
Determining an Effective UV Radiation Exposure Time for Vitamin D Synthesis in the Skin Without Risk to Health: Simplified Estimations from UV Observations
M Miyauchi, H Nakajima
Photochemistry and Photobiology 2016
Value of vitamin D assessment in patients with head and neck squamous cell cancer before treatment
BE Mostafa, HM Abdelmageed, MM El-Begermy, MS Taha, TA Hamdy, A Omran, N Lotfy
The Egyptian Journal of Otolaryngology 2016
Differences in the prevalence of vitamin D deficiency and hip fractures in nursing home residents and independently living elderly.
Shinkov A, Borissova AM, Dakovska L, Vlahov J, Kassabova L, Svinarov D, Krivoshiev S
Archives of Endocrinology and Metabolism 2016

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