An evaluation of surgically obtained skin (age range, 8-92 yr) revealed that there is an age-dependent decrease in the epidermal concentrations of provitamin D3 (7-dehydrocholesterol). To ascertain that aging indeed decreased the capacity of human skin to produce vitamin D3, some of the skin samples were exposed to ultraviolet radiation and the content of previtamin D3 was determined in the epidermis and dermis. The epidermis in the young and older subjects was the major site for the formation of previtamin D3, accounting for greater than 80% of the total previtamin D3 that was produced in the skin. A comparison of the amount of previtamin D3 produced in the skin from the 8- and 18-yr-old subjects with the amount produced in the skin from the 77- and 82-yr-old subjects revealed that aging can decrease by greater than twofold the capacity of the skin to produce previtamin D3. Recognition of this difference may be extremely important for the elderly, who infrequently expose a small area of skin to sunlight and who depend on this exposure for their vitamin D nutritional needs.
J MacLaughlin, M F Holick
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Title and authors | Publication | Year |
---|---|---|
Vitamin D, reactive oxygen species and calcium signalling in ageing and disease
MJ Berridge |
Philosophical Transactions of the Royal Society B: Biological Sciences | 2016 |
Association of low levels of vitamin D with chronic stable angina: A prospective case-control study
AH Raina, MS Allai, ZA Shah, KH Changal, MA Raina, FA Bhat |
North American Journal of Medical Sciences | 2016 |
Response of Vitamin D Concentration to Vitamin D 3 Administration in Older Adults without Sun Exposure: A Randomized Double-Blind Trial
JB Schwartz, L Kane, D Bikle |
Journal of the American Geriatrics Society | 2016 |
Endocrinology: Adult and Pediatric
M Gurnell, TJ Visser, P Beck-Peccoz, VK Chatterjee |
Endocrinology: Adult and Pediatric | 2016 |
Implications of the nutrition transition for vitamin D intake and status in Aboriginal groups in the Canadian Arctic
JE Fares, HA Weiler |
Nutrition Reviews | 2016 |
Osteoporosis in Older Persons
JA Cauley |
Osteoporosis in Older Persons | 2016 |
Vitamin D: not just the bone. Evidence for beneficial pleiotropic extraskeletal effects
M Caprio, M Infante, M Calanchini, C Mammi, A Fabbri |
Eating and Weight Disorders - Studies on Anorexia, Bulimia and Obesity | 2016 |
Vitamin D Deficiency Strongly Predicts Adverse Medical Outcome Across Different Medical Inpatient Populations: Results From a Prospective Study
L Graedel, M Merker, S Felder, A Kutz, S Haubitz, L Faessler, M Kaeslin, A Huber, B Mueller, P Schuetz |
Medicine | 2016 |
Vitamin D status and its predictors in New Zealand aged-care residents eligible for a government-funded universal vitamin D supplementation programme
SO MacDonell, JC Miller, MJ Harper, DL Waters, LA Houghton |
Public Health Nutrition | 2016 |
Vitamin D Levels and the Risk of Cognitive Decline in Chinese Elderly People: the Chinese Longitudinal Healthy Longevity Survey
DB Matchar, CL Chei, ZX Yin, V Koh, B Chakraborty, XM Shi, Y Zeng |
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences | 2016 |
Weight and skin colour as predictors of vitamin D status: results of an epidemiological investigation using nationally representative data
S Rajan, T Weishaar, B Keller |
Public Health Nutrition | 2016 |
A practical approach to secondary osteoporosis – Case studies in Asia
V Lim |
Osteoporosis and Sarcopenia | 2016 |
The impact of 1-year vitamin D supplementation on vitamin D status in athletes: a dose–response study
EM Backx, M Tieland, K Maase, AK Kies, M Mensink, LJ van Loon, LC de Groot |
European Journal of Clinical Nutrition | 2016 |
Nutritional Strategies Facing an Older Demographic: The Nutrition UP 65 Study Protocol
TF Amaral, A Santos, RS Guerra, AS Sousa, L Álvares, R Valdiviesso, C Afonso, P Padrão, C Martins, G Ferro, P Moreira, N Borges |
JMIR Research Protocols | 2016 |
Vitamin D level and its association with adiposity among multi-ethnic adults in Kuala Lumpur, Malaysia: a cross sectional study
IS Shafinaz, FM Moy |
BMC Public Health | 2016 |
Serum 25(OH)D seasonality in urologic patients from central Italy
A Calgani, M Iarlori, V Rizi, G Pace, M Bologna, C Vicentini, A Angelucci |
Journal of Photochemistry and Photobiology B: Biology | 2016 |
Major inter-personal variation in the increase and maximal level of 25-hydroxy vitamin D induced by UVB
P Datta, PA Philipsen, P Olsen, B Petersen, P Johansen, N Morling, HC Wulf |
Photochemical & Photobiological Sciences | 2016 |
Worldwide cutaneous malignant melanoma incidences analyzed by sex, age, and skin type over time (1955–2007): Is HPV infection of androgenic hair follicular melanocytes a risk factor for developing melanoma exclusively in people of European-ancestry?
SJ Merrill, M Subramanian, DE Godar |
Dermato-endocrinology | 2016 |
Vitamin D and Diabetic Complications: True or False Prophet?
U Alam, V Arul-Devah, S Javed, RA Malik |
Diabetes Therapy | 2016 |
Vitamin D, Cognition and Alzheimer’s Disease: The Therapeutic Benefit is in the D-Tails
V Landel, C Annweiler, P Millet, M Morello, F Féron, D Wion |
Journal of Alzheimer's disease : JAD | 2016 |
Vitamin D deficiency as adverse drug reaction? A cross-sectional study in Dutch geriatric outpatients
AC van Orten-Luiten, A Janse, RA Dhonukshe-Rutten, RF Witkamp |
European Journal of Clinical Pharmacology | 2016 |
Determinants of vitamin D supplementation prescription in nursing homes: a survey among general practitioners
F Buckinx, JY Reginster, E Cavalier, J Petermans, C Ricour, C Dardenne, O Bruyère |
Osteoporosis International | 2016 |
Environmental and genetic determinants of vitamin D status among older adults in London, UK
DA Jolliffe, Y Hanifa, KD Witt, TR Venton, M Rowe, PM Timms, E Hyppönen, RT Walton, CJ Griffiths, AR Martineau |
The Journal of Steroid Biochemistry and Molecular Biology | 2016 |
Vitamin D status among indigenous Mayan (Kekchi) and Afro-Caribe (Garifuna) adolescents from Guatemala: a comparative description between two ethnic groups residing on the Rio Dulce at the Caribbean coast in Izabal Province, Guatemala
A Naqvi, NW Solomons, R Campos, MJ Soto-Méndez, E Caplan, L Armas, OI Bermudez |
Public Health Nutrition | 2016 |
Vitamin D and Mammographic Findings
J Riedel, L Straub, J Wissing, A Artmann, M Schmidmayr, M Kiechle, V Seifert-Klauss |
Geburtshilfe und Frauenheilkunde | 2016 |
Farming, Foreign Holidays, and Vitamin D in Orkney
E Weiss, L Zgaga, S Read, S Wild, MG Dunlop, H Campbell, R McQuillan, JF Wilson, AT Slominski |
PloS one | 2016 |
Assessment of prevalence of hypovitaminosis D in multiethnic population of the United Arab Emirates
SB Sridhar, PG Rao, SK Multani, M Jain |
Journal of Advanced Pharmaceutical Technology & Research | 2016 |
Recommendations for managing cutaneous disorders associated with advancing age
S Seite, P Humbert, B Dreno, J Krutmann, T Luger, R Triller, S Meaume |
Clinical Interventions in Aging | 2016 |
Global Consensus Recommendations on Prevention and Management of Nutritional Rickets
CF Munns, N Shaw, M Kiely, BL Specker, TD Thacher, K Ozono, T Michigami, D Tiosano, MZ Mughal, O Mäkitie, L Ramos-Abad, L Ward, LA DiMeglio, N Atapattu, H Cassinelli, C Braegger, JM Pettifor, A Seth, HW Idris, V Bhatia, J Fu, G Goldberg, L Sävendahl, R Khadgawat, P Pludowski, J Maddock, E Hyppönen, A Oduwole, E Frew, M Aguiar, T Tulchinsky, G Butler, W Högler |
The Journal of clinical endocrinology and metabolism | 2016 |
Nutritional Influences on Bone Health
CM Weaver, S Jakeman |
Nutritional Influences on Bone Health | 2016 |
Vitamin D in sarcopenia: Understanding its role in pathogenesis, prevention and treatment
G Arik, Z Ulger |
European Geriatric Medicine | 2016 |
Osteoporosis: An under-recognized public health problem: Local and global risk factors and its regional and worldwide prevalence
R Vijayakumar, D Büsselberg |
Journal of Local and Global Health Science | 2016 |
Vitamin D and cognition
H Wehr, M Bednarska-Makaruk |
Postępy Psychiatrii i Neurologii | 2016 |
Vitamin D Intake and Serum 25-Hydroxyvitamin D Levels in Korean Adults: Analysis of the 2009 Korea National Health and Nutrition Examination Survey (KNHANES IV-3) Using a Newly Established Vitamin D Database
K Yoo, J Cho, S Ly |
Nutrients | 2016 |
Prevalence of vitamin D deficiency in orthopaedic patients – A single centre study
CP Pal, H Kumar, D Kumar, V Mittal, G Deshwar, D Altaf, S Verma |
Journal of Clinical Orthopaedics and Trauma | 2016 |
Serum 25-hydroxyvitamin D levels in a healthy population from the North of Portugal
A Bettencourt, D Boleixa, J Reis, JC Oliveira, D Mendonça, PP Costa, BM da Silva, A Marinho, AM da Silva |
The Journal of Steroid Biochemistry and Molecular Biology | 2016 |
The benefits of utilising geo-mapping for visualising the vitamin D status of Dublin city and the surrounding urban districts
E Laird, T Shannon, VE Crowley, M Healy |
Irish Journal of Medical Science | 2016 |
Endocrinology
C Napier, SH Pearce |
Endocrinology | 2016 |
Association of Vitamin D Deficiency and Thyroid Function in Postmenopausal Women
M Niafar, L Pourafkari, S Aminmozaffari, ND Nader |
Advanced pharmaceutical bulletin | 2016 |
Low Prevalence of Vitamin D Insufficiency among Nepalese Infants Despite High Prevalence of Vitamin D Insufficiency among Their Mothers
J Haugen, M Ulak, R Chandyo, S Henjum, A Thorne-Lyman, P Ueland, Ø Midtun, P Shrestha, T Strand |
Nutrients | 2016 |
Correlation of objectively measured light exposure and serum vitamin D in men aged over 60 years
AJ Fields, SE Linnville, RE Hoyt |
Health Psychology Open | 2016 |
Association between Vitamin D Deficiency and Antinuclear Antibodies in Middle-Aged and Older U.S. Adults
HC Meier, DP Sandler, EM Simonsick, CG Parks |
Cancer epidemiology, biomarkers & prevention | 2016 |
Differences in the prevalence of vitamin D deficiency and hip fractures in nursing home residents and independently living elderly
A Shinkov, AM Borissova, L Dakovska, J Vlahov, L Kassabova, D Svinarov, S Krivoshiev |
Archives of Endocrinology and Metabolism | 2016 |
Association between the serum 25-hydroxyvitamin D level and allergic rhinitis in Korean children
SH Yoon, JY Kim, YH Kim, YA Park, IS Sol, MJ Kim, KW Kim, MH Sohn, KE Kim |
Allergy Asthma & Respiratory Disease | 2016 |
Determining an Effective UV Radiation Exposure Time for Vitamin D Synthesis in the Skin Without Risk to Health: Simplified Estimations from UV Observations
M Miyauchi, H Nakajima |
Photochemistry and Photobiology | 2016 |
Value of vitamin D assessment in patients with head and neck squamous cell cancer before treatment
BE Mostafa, HM Abdelmageed, MM El-Begermy, MS Taha, TA Hamdy, A Omran, N Lotfy |
The Egyptian Journal of Otolaryngology | 2016 |
Differences in the prevalence of vitamin D deficiency and hip fractures in nursing home residents and independently living elderly.
Shinkov A, Borissova AM, Dakovska L, Vlahov J, Kassabova L, Svinarov D, Krivoshiev S |
Archives of Endocrinology and Metabolism | 2016 |