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Citations to this article

Aging decreases the capacity of human skin to produce vitamin D3.
J MacLaughlin, M F Holick
J MacLaughlin, M F Holick
Published October 1, 1985
Citation Information: J Clin Invest. 1985;76(4):1536-1538. https://doi.org/10.1172/JCI112134.
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Research Article Article has an altmetric score of 135

Aging decreases the capacity of human skin to produce vitamin D3.

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Abstract

An evaluation of surgically obtained skin (age range, 8-92 yr) revealed that there is an age-dependent decrease in the epidermal concentrations of provitamin D3 (7-dehydrocholesterol). To ascertain that aging indeed decreased the capacity of human skin to produce vitamin D3, some of the skin samples were exposed to ultraviolet radiation and the content of previtamin D3 was determined in the epidermis and dermis. The epidermis in the young and older subjects was the major site for the formation of previtamin D3, accounting for greater than 80% of the total previtamin D3 that was produced in the skin. A comparison of the amount of previtamin D3 produced in the skin from the 8- and 18-yr-old subjects with the amount produced in the skin from the 77- and 82-yr-old subjects revealed that aging can decrease by greater than twofold the capacity of the skin to produce previtamin D3. Recognition of this difference may be extremely important for the elderly, who infrequently expose a small area of skin to sunlight and who depend on this exposure for their vitamin D nutritional needs.

Authors

J MacLaughlin, M F Holick

×

Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 1989 1988 1987 1986 1985 1981 1971 Total
Citations: 6 25 14 29 43 60 33 38 49 47 50 47 57 40 49 47 42 30 28 32 25 14 15 11 7 11 15 10 15 2 7 5 10 4 4 7 11 5 4 2 1 1 1 953
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2007 (28)

Title and authors Publication Year
Handbook of Nutrition and Food, Second Edition
C Berdanier
Handbook of Nutrition and Food, Second Edition 2007
Age-related decrease in serum 25-hydroxyvitamin D concentrations in the frail elderly: a longitudinal study
K Nakamura, T Nishiwaki, K Ueno, M Yamamoto
Journal of Bone and Mineral Metabolism 2007
The effect of outfitting style on bone mineral density
T Güler, F Sivas, BM Başkan, Ö Günesen, E Alemdaroğlu, K Özoran
Rheumatology International 2007
Optimizing Women's Health through Nutrition
T Wolever, J Vogt
Optimizing Women's Health through Nutrition 2007
UVB therapy increases 25(OH) vitamin D syntheses in postmenopausal women with psoriasis
A Osmancevic, K Landin-Wilhelmsen, O Larkö, D Mellström, AM Wennberg, L Hulthén, AL Krogstad
Photodermatology, Photoimmunology & Photomedicine 2007
Prostate cancer survival is dependent on season of diagnosis
Z Lagunova, AC Porojnicu, A Dahlback, JP Berg, TM Beer, J Moan
The Prostate 2007
Roles of solar UV radiation and vitamin D in human health and how to obtain vitamin D
WB Grant
Expert Review of Dermatology 2007
Seasonal and geographical variations in lung cancer prognosis in Norway
AC Porojnicu, TE Robsahm, A Dahlback, JP Berg, D Christiani, ØS Bruland, J Moan
Lung Cancer 2007
A Quality Improvement Study on Calcium and Vitamin D Supplementation in Long-term Care
J Munir, RJ Wright, DB Carr
Journal of the American Medical Directors Association 2007
Effect of UV Radiation on the Neonatal Skin Immune System- Implications for Melanoma†
HK Muller, RC Malley, HM McGee, DK Scott, T Wozniak, GM Woods
Photochemistry and Photobiology 2007
Prevalence of vitamin D inadequacy in European postmenopausal women
O Bruyère, O Malaise, A Neuprez, J Collette, JY Reginster
Current Medical Research and Opinion 2007
Prescriptions for vitamin Damong patients taking antiresorptive agents in Canada
DA Hanley, Q Zhang, MC Meilleur, P Mavros, SS Sen
Current Medical Research and Opinion 2007
Ultraviolet-B radiation increases serum 25-hydroxyvitamin D levels: The effect of UVB dose and skin color
LA Armas, S Dowell, M Akhter, S Duthuluru, C Huerter, BW Hollis, R Lund, RP Heaney
Journal of the American Academy of Dermatology 2007
Vitamin D and outcomes in chronic kidney disease
S Cheng, D Coyne
Current Opinion in Nephrology and Hypertension 2007
Vitamin D inadequacy in Belgian postmenopausal osteoporotic women
A Neuprez, O Bruyère, J Collette, JY Reginster
BMC Public Health 2007
Factors that influence the cutaneous synthesis and dietary sources of vitamin D
TC Chen, F Chimeh, Z Lu, J Mathieu, KS Person, A Zhang, N Kohn, S Martinello, R Berkowitz, MF Holick
Archives of Biochemistry and Biophysics 2007
Not enough vitamin D: health consequences for Canadians
G Schwalfenberg
Canadian family physician Médecin de famille canadien 2007
Osteoporosis in Men
L Gennari, JP Bilezikian
Endocrinology & Metabolism Clinics of North America 2007
Treatment of the Postmenopausal Woman
FS Keating, JC Stevenson
Treatment of the Postmenopausal Woman 2007
Metabolismo, fuentes endógenas y exógenas de vitamina D
MÁ Zanuy, FH Carranza
Revista Española de Enfermedades Metabólicas Óseas 2007
Low 25-hydroxyvitamin D concentrations in obese women: Their clinical significance and relationship with anthropometric and body composition variables
N Vilarrasa, J Maravall, A Estepa, R Sánchez, C Masdevall, MA Navarro, P Alía, J Soler, JM Gómez
Journal of Endocrinological Investigation 2007
Vitamina d y función muscular
S Guadalix, E Jódar
Revista Española de Enfermedades Metabólicas Óseas 2007
Colon cancer: Prognosis for different latitudes, age groups and seasons in Norway
J Moan, A Porojnicu, Z Lagunova, JP Berg, A Dahlback
Journal of Photochemistry and Photobiology B: Biology 2007
A Study of Vitamin D Insufficiency in Postmenopausal Type 2 Diabetic Women
E Sultan, E Alfadahli, L Hassan, N Abdulghany
Journal of Taibah University Medical Sciences 2007
Vitamin D and Rehabilitation: Improving Functional Outcomes
L Shinchuk, MF Holick
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition 2007
Correlação entre fotoproteção e concentrações de 25 hidroxi-vitamina D e paratormônio
M Maia, SS Maeda, C Marçon
Anais Brasileiros de Dermatologia 2007
Low Vitamin D Status despite Abundant Sun Exposure
N Binkley, R Novotny, D Krueger, T Kawahara, YG Daida, G Lensmeyer, BW Hollis, MK Drezner
The Journal of clinical endocrinology and metabolism 2007
Clinical Trials in Osteoporosis
D Pearson, CG Miller
2007

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