An evaluation of surgically obtained skin (age range, 8-92 yr) revealed that there is an age-dependent decrease in the epidermal concentrations of provitamin D3 (7-dehydrocholesterol). To ascertain that aging indeed decreased the capacity of human skin to produce vitamin D3, some of the skin samples were exposed to ultraviolet radiation and the content of previtamin D3 was determined in the epidermis and dermis. The epidermis in the young and older subjects was the major site for the formation of previtamin D3, accounting for greater than 80% of the total previtamin D3 that was produced in the skin. A comparison of the amount of previtamin D3 produced in the skin from the 8- and 18-yr-old subjects with the amount produced in the skin from the 77- and 82-yr-old subjects revealed that aging can decrease by greater than twofold the capacity of the skin to produce previtamin D3. Recognition of this difference may be extremely important for the elderly, who infrequently expose a small area of skin to sunlight and who depend on this exposure for their vitamin D nutritional needs.
J MacLaughlin, M F Holick
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Title and authors | Publication | Year |
---|---|---|
Handbook of Nutrition and Food, Second Edition
C Berdanier |
Handbook of Nutrition and Food, Second Edition | 2007 |
Age-related decrease in serum 25-hydroxyvitamin D concentrations in the frail elderly: a longitudinal study
K Nakamura, T Nishiwaki, K Ueno, M Yamamoto |
Journal of Bone and Mineral Metabolism | 2007 |
The effect of outfitting style on bone mineral density
T Güler, F Sivas, BM Başkan, Ö Günesen, E Alemdaroğlu, K Özoran |
Rheumatology International | 2007 |
Optimizing Women's Health through Nutrition
T Wolever, J Vogt |
Optimizing Women's Health through Nutrition | 2007 |
UVB therapy increases 25(OH) vitamin D syntheses in postmenopausal women with psoriasis
A Osmancevic, K Landin-Wilhelmsen, O Larkö, D Mellström, AM Wennberg, L Hulthén, AL Krogstad |
Photodermatology, Photoimmunology & Photomedicine | 2007 |
Prostate cancer survival is dependent on season of diagnosis
Z Lagunova, AC Porojnicu, A Dahlback, JP Berg, TM Beer, J Moan |
The Prostate | 2007 |
Roles of solar UV radiation and vitamin D in human health and how to obtain vitamin D
WB Grant |
Expert Review of Dermatology | 2007 |
Seasonal and geographical variations in lung cancer prognosis in Norway
AC Porojnicu, TE Robsahm, A Dahlback, JP Berg, D Christiani, ØS Bruland, J Moan |
Lung Cancer | 2007 |
A Quality Improvement Study on Calcium and Vitamin D Supplementation in Long-term Care
J Munir, RJ Wright, DB Carr |
Journal of the American Medical Directors Association | 2007 |
Effect of UV Radiation on the Neonatal Skin Immune System- Implications for Melanoma†
HK Muller, RC Malley, HM McGee, DK Scott, T Wozniak, GM Woods |
Photochemistry and Photobiology | 2007 |
Prevalence of vitamin D inadequacy in European postmenopausal women
O Bruyère, O Malaise, A Neuprez, J Collette, JY Reginster |
Current Medical Research and Opinion | 2007 |
Prescriptions for vitamin Damong patients taking antiresorptive agents in Canada
DA Hanley, Q Zhang, MC Meilleur, P Mavros, SS Sen |
Current Medical Research and Opinion | 2007 |
Ultraviolet-B radiation increases serum 25-hydroxyvitamin D levels: The effect of UVB dose and skin color
LA Armas, S Dowell, M Akhter, S Duthuluru, C Huerter, BW Hollis, R Lund, RP Heaney |
Journal of the American Academy of Dermatology | 2007 |
Vitamin D and outcomes in chronic kidney disease
S Cheng, D Coyne |
Current Opinion in Nephrology and Hypertension | 2007 |
Vitamin D inadequacy in Belgian postmenopausal osteoporotic women
A Neuprez, O Bruyère, J Collette, JY Reginster |
BMC Public Health | 2007 |
Factors that influence the cutaneous synthesis and dietary sources of vitamin D
TC Chen, F Chimeh, Z Lu, J Mathieu, KS Person, A Zhang, N Kohn, S Martinello, R Berkowitz, MF Holick |
Archives of Biochemistry and Biophysics | 2007 |
Not enough vitamin D: health consequences for Canadians
G Schwalfenberg |
Canadian family physician Médecin de famille canadien | 2007 |
Osteoporosis in Men
L Gennari, JP Bilezikian |
Endocrinology & Metabolism Clinics of North America | 2007 |
Treatment of the Postmenopausal Woman
FS Keating, JC Stevenson |
Treatment of the Postmenopausal Woman | 2007 |
Metabolismo, fuentes endógenas y exógenas de vitamina D
MÁ Zanuy, FH Carranza |
Revista Española de Enfermedades Metabólicas Óseas | 2007 |
Low 25-hydroxyvitamin D concentrations in obese women: Their clinical significance and relationship with anthropometric and body composition variables
N Vilarrasa, J Maravall, A Estepa, R Sánchez, C Masdevall, MA Navarro, P Alía, J Soler, JM Gómez |
Journal of Endocrinological Investigation | 2007 |
Vitamina d y función muscular
S Guadalix, E Jódar |
Revista Española de Enfermedades Metabólicas Óseas | 2007 |
Colon cancer: Prognosis for different latitudes, age groups and seasons in Norway
J Moan, A Porojnicu, Z Lagunova, JP Berg, A Dahlback |
Journal of Photochemistry and Photobiology B: Biology | 2007 |
A Study of Vitamin D Insufficiency in Postmenopausal Type 2 Diabetic Women
E Sultan, E Alfadahli, L Hassan, N Abdulghany |
Journal of Taibah University Medical Sciences | 2007 |
Vitamin D and Rehabilitation: Improving Functional Outcomes
L Shinchuk, MF Holick |
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition | 2007 |
Correlação entre fotoproteção e concentrações de 25 hidroxi-vitamina D e paratormônio
M Maia, SS Maeda, C Marçon |
Anais Brasileiros de Dermatologia | 2007 |
Low Vitamin D Status despite Abundant Sun Exposure
N Binkley, R Novotny, D Krueger, T Kawahara, YG Daida, G Lensmeyer, BW Hollis, MK Drezner |
The Journal of clinical endocrinology and metabolism | 2007 |
Clinical Trials in Osteoporosis
D Pearson, CG Miller |
2007 |