An evaluation of surgically obtained skin (age range, 8-92 yr) revealed that there is an age-dependent decrease in the epidermal concentrations of provitamin D3 (7-dehydrocholesterol). To ascertain that aging indeed decreased the capacity of human skin to produce vitamin D3, some of the skin samples were exposed to ultraviolet radiation and the content of previtamin D3 was determined in the epidermis and dermis. The epidermis in the young and older subjects was the major site for the formation of previtamin D3, accounting for greater than 80% of the total previtamin D3 that was produced in the skin. A comparison of the amount of previtamin D3 produced in the skin from the 8- and 18-yr-old subjects with the amount produced in the skin from the 77- and 82-yr-old subjects revealed that aging can decrease by greater than twofold the capacity of the skin to produce previtamin D3. Recognition of this difference may be extremely important for the elderly, who infrequently expose a small area of skin to sunlight and who depend on this exposure for their vitamin D nutritional needs.
J MacLaughlin, M F Holick
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Title and authors | Publication | Year |
---|---|---|
Vitamin D Deficiency in Early Life and the Potential Programming of Cardiovascular Disease in Adulthood
O Gezmish, MJ Black |
Journal of Cardiovascular Translational Research | 2013 |
Sunlight and Vitamin D
M Wacker, MF Holick |
Dermato-endocrinology | 2013 |
Vitamin D for Health: A Global Perspective
A Hossein-nezhad, MF Holick |
Mayo Clinic Proceedings | 2013 |
Vitamin d status and spine surgery outcomes
WJ Rodriguez, J Gromelski |
ISRN Orthopedics | 2013 |
Calcium Regulation and Bone Mineral Metabolism in Elderly Patients with Chronic Kidney Disease
V Tejwani, Q Qian |
Nutrients | 2013 |
Vitamin d status among older community dwelling men living in a sunny country and associations with lifestyle factors: The concord health and ageing in men project, Sydney, Australia
V Hirani, RG Cumming, FM Blyth, V Naganathan, DG Couteur, DJ Handelsman, LM Waite, MJ Seibel |
The journal of nutrition, health & aging | 2013 |
Vitamin D Status in Korea
HS Choi |
Endocrinology and Metabolism | 2013 |
Additive association of vitamin D insufficiency and sarcopenia with low femoral bone mineral density in noninstitutionalized elderly population: the Korea National Health and Nutrition Examination Surveys 2009–2010
SG Lee, Y Lee, KJ Kim, W Lee, OH Kwon, JH Kim |
Osteoporosis International | 2013 |
Vitamin D and Aging
JC Gallagher |
Endocrinology and metabolism clinics of North America | 2013 |
Measurement of Serum Total Vitamin D (25-OH) Using Automated Immunoassay in Comparision With Liquid Chromatography Tandem-Mass Spectrometry: Automated Immunoassay for Vitamin D
SY Shin, MJ Kwon, J Song, H Park, HY Woo |
Journal of Clinical Laboratory Analysis | 2013 |
Seldin and Giebisch's The Kidney
CJ Cooper, LD Dworkin, WL Henrich |
Seldin and Giebisch's The Kidney | 2013 |
Vitamin D supplementation in elderly or postmenopausal women: A 2013 update of the 2008 recommendations from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO)
R Rizzoli, S Boonen, ML Brandi, O Bruyère, C Cooper, JA Kanis, JM Kaufman, JD Ringe, G Weryha, JY Reginster |
Current Medical Research and Opinion | 2013 |
Predictors of vitamin D deficiency and insufficiency in adult Bahrainis: a cross-sectional study
J Golbahar, N Al-Saffar, DA Diab, S Al-Othman, A Darwish, G Al-Kafaji |
Public Health Nutrition | 2013 |
Practice implications for preventing population vulnerability related to vitamin D status: Practice implications of vitamin D status
A Collins |
Journal of the American Academy of Nurse Practitioners | 2013 |
A glimpse of vitamin D status in Mainland China
W Zhang, E Stoecklin, M Eggersdorfer |
Nutrition | 2013 |
Diagnosis and Treatment of Osteoporosis in Older Adults
DL Diab, NB Watts |
Endocrinology and metabolism clinics of North America | 2013 |
Vitamin D status and resistance exercise training independently affect glucose tolerance in older adults
VM Kobza, JC Fleet, J Zhou, TB Conley, M Peacock, HB IglayReger, G DePalma, WW Campbell |
Nutrition Research | 2013 |
Nutrition in the Elderly. Frequently Asked Questions
BK John, M Bullock, L Brenner, C McGaw, JS Scolapio |
The American Journal of Gastroenterology | 2013 |
Relationship between serum 25-hydroxyvitamin D status and cardiorespiratory fitness: Findings from the National Health and Nutrition Examination Survey
PB Wilson, JS Fitzgerald, SJ Ingraham |
International Journal of Cardiology | 2013 |
Phototherapy with UVB narrowband, UVA/UVBnb, and UVA1 differentially impacts serum 25-hydroxyvitamin-D3
L Feldmeyer, G Shojaati, KS Spanaus, A Navarini, B Theler, D Donghi, M Urosevic-Maiwald, M Glatz, L Imhof, MJ Barysch, R Dummer, M Roos, LE French, C Surber, GF Hofbauer |
Journal of the American Academy of Dermatology | 2013 |
Reliability of self-reported sun exposure in Canadian women and estimation of lifetime exposure to vitamin D from sun and diet
LS Cook, BL Moon, Y Dong, HK Neilson |
Public Health Nutrition | 2013 |
Osteoporosis: Diagnosis and Management
S Silverman, S Venuturupalli |
Osteoporosis: Diagnosis and Management | 2013 |
The effect of body mass index on optimal vitamin D status in U.S. adults: The National Health and Nutrition Examination Survey 2001–2006
L Samuel, LN Borrell |
Annals of Epidemiology | 2013 |
Protocolo de tratamiento de la deficiencia de vitamina D
FJ Rey |
Medicina Clínica | 2013 |
Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism
MD Ruppe, SM de Beur |
Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism | 2013 |
Vitamin D and bone health outcomes in older age
TR Hill, TJ Aspray, RM Francis |
Proceedings of the Nutrition Society | 2013 |
Nutrition and Type 2 Diabetes: Etiology and Prevention
S Liu, Y Song |
Nutrition and Type 2 Diabetes: Etiology and Prevention | 2013 |
Vitamin D and UV exposure in chronic kidney disease
R Krause |
Dermato-endocrinology | 2013 |
Seasonal variation in the serum 25-hydroxyvitamin D levels of young and elderly active and inactive adults in São Paulo, Brazil: The São PAulo Vitamin D Evaluation Study (SPADES)
SS Maeda, GL Saraiva, LF Hayashi, MS Cendoroglo, LR Ramos, MP Corrêa, CH de Mesquita, M Lazaretti-Castro |
Dermato-endocrinology | 2013 |
Effects of sunlight on behavior and 25-hydroxyvitamin D levels in two species of Old World fruit bats
LO Southworth, MF Holick, TC Chen, TH Kunz |
Dermato-endocrinology | 2013 |
Vitamin D status and sun exposure in southeast Asia
H Nimitphong, MF Holick |
Dermato-endocrinology | 2013 |
Prevalence of vitamin D deficiency during the summer and its relationship with sun exposure and skin phototype in elderly men living in the tropics
MA Cabral, CN Borges, JM Maia, CA Aires, F Bandeira |
Clinical Interventions in Aging | 2013 |
Vitamin D - a systematic literature review for the 5th edition of the Nordic Nutrition Recommendations
C Lamberg-Allardt, M Brustad, HE Meyer, L Steingrimsdottir |
Food & Nutrition Research | 2013 |
DHCR7 mutations linked to higher vitamin D status allowed early human migration to northern latitudes
V Kuan, AR Martineau, CJ Griffiths, E Hyppönen, R Walton |
BMC Evolutionary Biology | 2013 |
Vitamin D status of older adults of diverse ancestry living in the greater Toronto area
JK Ginter, S Krithika, A Gozdzik, H Hanwell, S Whiting, EJ Parra |
BMC geriatrics | 2013 |
Factors affecting vitamin D status in different populations in the city of Sao Paulo, Brazil: the Sao PAulo vitamin D Evaluation Study (SPADES)
SS Maeda, GL Saraiva, IS Kunii, LF Hayashi, MS Cendoroglo, LR Ramos, M Lazaretti-Castro |
BMC Endocrine Disorders | 2013 |
Sunlight and other determinants of circulating 25-hydroxyvitamin D levels in black and white participants in a nationwide U.S. study
DM Freedman, EK Cahoon, P Rajaraman, JM Major, MM Doody, BH Alexander, RW Hoffbeck, MG Kimlin, BI Graubard, MS Linet |
American Journal of Epidemiology | 2013 |
Clinical Practice Guidelines for Healthy Eating for the Prevention and Treatment of Metabolic and Endocrine Diseases in Adults: Cosponsored by The American Association of Clinical Endocrinologists/The American College of Endocrinology and The Obesity Society
JM Gonzalez-Campoy, ST st. Jeor, K Castorino, A Ebrahim, D Hurley, L Jovanovic, JI Mechanick, SM Petak, YH Yu, KA Harris, P Kris-Etherton, R Kushner, M Molini-Blandford, QT Nguyen, R Plodkowski, DB Sarwer, KT Thomas |
Endocrine Practice | 2013 |
Low vitamin D status is associated with reduced muscle mass and impaired physical performance in frail elderly people
M Tieland, EM Brouwer-Brolsma, C Nienaber-Rousseau, LJ van Loon, LC de Groot |
European Journal of Clinical Nutrition | 2013 |
Impact of seasonal and geographical differences on breast cancer survival
HW Kwon, JW Lee, HJ Kim, BS Koh, JH Yu, JW Lee, BH Son, SH Ahn |
Korean Journal of Clinical Oncology | 2013 |
Prevalence of Vitamin D Deficiency and Association with Functional Status in Newly Admitted Male Veteran Nursing Home Residents
G Kojima, A Tamai, K Masaki, G Gatchell, J Epure, C China, GW Ross, H Petrovitch, M Tanabe |
Journal of the American Geriatrics Society | 2013 |
Solar ultraviolet radiation in South Africa: clinical consequences for the skin
CY Wright, LM Davids, B Summers, M Norval |
Expert Review of Dermatology | 2013 |
Analysis of vitamin D metabolic markers by mass spectrometry: Current techniques, limitations of the “gold standard” method, and anticipated future directions: MEASURING VITAMIN D METABOLIC MARKERS BY MASS SPECTROMETRY
DA Volmer, LR Mendes, CS Stokes |
Mass Spectrometry Reviews | 2013 |
Vitamin D and maternal and child health: Overview and implications for dietary requirements: Vitamin D and Maternal and Child Health
JY Uriu-Adams, SG Obican, CL Keen |
Birth Defects Research Part C Embryo Today Reviews | 2013 |
Quality of dietary intake in relation to body composition in patients with chronic obstructive pulmonary disease eligible for pulmonary rehabilitation
C de Bool, C Mattijssen-Verdonschot, PP van Melick, MA Spruit, FM Franssen, EF Wouters, AM Schols, EP Rutten |
European Journal of Clinical Nutrition | 2013 |
Vitamin D and Cardiovascular Disease: An Appraisal of the Evidence
PF Schnatz, JE Manson |
Clinical chemistry | 2013 |
Bisphosphonates and adipogenesis: Evidence for alendronate inhibition of adipocyte differentiation in 3T3-L1 preadipocytes through a vitamin D receptor mediated effect
C Mammi, M Calanchini, A Antelmi, A Feraco, L Gnessi, S Falcone, F Quintarelli, GM Rosano, A Fabbri, M Caprio |
Natural Science | 2013 |
Less than Adequate Vitamin D Status and Intake in Latin America and the Caribbean: A Problem of Unknown Magnitude
A Brito, H Cori, M Olivares, MF Mujica, G Cediel, DL de Romaña |
Food and nutrition bulletin | 2013 |
Influence of altitude on vitamin D and bone metabolism of lactating sheep and goats1
M Kohler, F Leiber, H Willems, L Merbold, A Liesegang |
Journal of animal science | 2013 |
Prevalence of Vitamin D Deficiency Among Patients After Kidney Transplantation in Latvia
I Ādamsone, I Folkmane, D Amerika, R Rozentāls |
Proceedings of the Latvian Academy of Sciences Section B Natural Exact and Applied Sciences | 2013 |
Prevalence of Vitamin D Insufficiency and Associated Factors Among Canadian Cree: A Cross-sectional Study
B Riverin, E Dewailly, S Côté, L Johnson-Down, S Morin, S Dodin |
Canadian journal of public health. Revue canadienne de sante publique | 2013 |
Diet Quality
VR Preedy, LA Hunter, VB Patel |
2013 | |
Building healthy bones throughout life: an evidence‐informed strategy to prevent osteoporosis in Australia
PR Ebeling, RM Daly, DA Kerr, MG Kimlin |
The Medical Journal of Australia | 2013 |
High serum vitamin D levels reduce the risk for nonalcoholic fatty liver disease in healthy men independent of metabolic syndrome
EJ Rhee, MK Kim, SE Park, CY Park, KH Baek, WY Lee, MI Kang, SW Park, SW Kim, KW Oh |
Endocrine Journal | 2013 |
Quality of dietary intake in relation to body composition in patients with chronic obstructive pulmonary disease eligible for pulmonary rehabilitation
C van de Bool, C Mattijssen-Verdonschot, PP van Melick, MA Spruit, FM Franssen, EF Wouters, AM Schols, EP Rutten |
European Journal of Clinical Nutrition | 2013 |
Predictors of vitamin D deficiency and insufficiency in adult Bahrainis: a cross-sectional study.
Golbahar J, Al-Saffar N, Altayab Diab D, Al-Othman S, Darwish A, Al-Kafaji G |
Public Health Nutrition | 2013 |
Reliability of self-reported sun exposure in Canadian women and estimation of lifetime exposure to vitamin D from sun and diet.
Cook LS, Moon BL, Dong Y, Neilson HK |
Public Health Nutrition | 2013 |