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Citations to this article

Aging decreases the capacity of human skin to produce vitamin D3.
J MacLaughlin, M F Holick
J MacLaughlin, M F Holick
Published October 1, 1985
Citation Information: J Clin Invest. 1985;76(4):1536-1538. https://doi.org/10.1172/JCI112134.
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Research Article Article has an altmetric score of 135

Aging decreases the capacity of human skin to produce vitamin D3.

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Abstract

An evaluation of surgically obtained skin (age range, 8-92 yr) revealed that there is an age-dependent decrease in the epidermal concentrations of provitamin D3 (7-dehydrocholesterol). To ascertain that aging indeed decreased the capacity of human skin to produce vitamin D3, some of the skin samples were exposed to ultraviolet radiation and the content of previtamin D3 was determined in the epidermis and dermis. The epidermis in the young and older subjects was the major site for the formation of previtamin D3, accounting for greater than 80% of the total previtamin D3 that was produced in the skin. A comparison of the amount of previtamin D3 produced in the skin from the 8- and 18-yr-old subjects with the amount produced in the skin from the 77- and 82-yr-old subjects revealed that aging can decrease by greater than twofold the capacity of the skin to produce previtamin D3. Recognition of this difference may be extremely important for the elderly, who infrequently expose a small area of skin to sunlight and who depend on this exposure for their vitamin D nutritional needs.

Authors

J MacLaughlin, M F Holick

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 1989 1988 1987 1986 1985 1981 1971 Total
Citations: 6 25 14 29 43 60 33 38 49 47 50 47 57 40 49 47 42 30 28 32 25 14 15 11 7 11 15 10 15 2 7 5 10 4 4 7 11 5 4 2 1 1 1 953
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2013 (57)

Title and authors Publication Year
Vitamin D Deficiency in Early Life and the Potential Programming of Cardiovascular Disease in Adulthood
O Gezmish, MJ Black
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Vitamin D for Health: A Global Perspective
A Hossein-nezhad, MF Holick
Mayo Clinic Proceedings 2013
Vitamin d status and spine surgery outcomes
WJ Rodriguez, J Gromelski
ISRN Orthopedics 2013
Calcium Regulation and Bone Mineral Metabolism in Elderly Patients with Chronic Kidney Disease
V Tejwani, Q Qian
Nutrients 2013
Vitamin d status among older community dwelling men living in a sunny country and associations with lifestyle factors: The concord health and ageing in men project, Sydney, Australia
V Hirani, RG Cumming, FM Blyth, V Naganathan, DG Couteur, DJ Handelsman, LM Waite, MJ Seibel
The journal of nutrition, health & aging 2013
Vitamin D Status in Korea
HS Choi
Endocrinology and Metabolism 2013
Additive association of vitamin D insufficiency and sarcopenia with low femoral bone mineral density in noninstitutionalized elderly population: the Korea National Health and Nutrition Examination Surveys 2009–2010
SG Lee, Y Lee, KJ Kim, W Lee, OH Kwon, JH Kim
Osteoporosis International 2013
Vitamin D and Aging
JC Gallagher
Endocrinology and metabolism clinics of North America 2013
Measurement of Serum Total Vitamin D (25-OH) Using Automated Immunoassay in Comparision With Liquid Chromatography Tandem-Mass Spectrometry: Automated Immunoassay for Vitamin D
SY Shin, MJ Kwon, J Song, H Park, HY Woo
Journal of Clinical Laboratory Analysis 2013
Seldin and Giebisch's The Kidney
CJ Cooper, LD Dworkin, WL Henrich
Seldin and Giebisch's The Kidney 2013
Vitamin D supplementation in elderly or postmenopausal women: A 2013 update of the 2008 recommendations from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO)
R Rizzoli, S Boonen, ML Brandi, O Bruyère, C Cooper, JA Kanis, JM Kaufman, JD Ringe, G Weryha, JY Reginster
Current Medical Research and Opinion 2013
Predictors of vitamin D deficiency and insufficiency in adult Bahrainis: a cross-sectional study
J Golbahar, N Al-Saffar, DA Diab, S Al-Othman, A Darwish, G Al-Kafaji
Public Health Nutrition 2013
Practice implications for preventing population vulnerability related to vitamin D status: Practice implications of vitamin D status
A Collins
Journal of the American Academy of Nurse Practitioners 2013
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W Zhang, E Stoecklin, M Eggersdorfer
Nutrition 2013
Diagnosis and Treatment of Osteoporosis in Older Adults
DL Diab, NB Watts
Endocrinology and metabolism clinics of North America 2013
Vitamin D status and resistance exercise training independently affect glucose tolerance in older adults
VM Kobza, JC Fleet, J Zhou, TB Conley, M Peacock, HB IglayReger, G DePalma, WW Campbell
Nutrition Research 2013
Nutrition in the Elderly. Frequently Asked Questions
BK John, M Bullock, L Brenner, C McGaw, JS Scolapio
The American Journal of Gastroenterology 2013
Relationship between serum 25-hydroxyvitamin D status and cardiorespiratory fitness: Findings from the National Health and Nutrition Examination Survey
PB Wilson, JS Fitzgerald, SJ Ingraham
International Journal of Cardiology 2013
Phototherapy with UVB narrowband, UVA/UVBnb, and UVA1 differentially impacts serum 25-hydroxyvitamin-D3
L Feldmeyer, G Shojaati, KS Spanaus, A Navarini, B Theler, D Donghi, M Urosevic-Maiwald, M Glatz, L Imhof, MJ Barysch, R Dummer, M Roos, LE French, C Surber, GF Hofbauer
Journal of the American Academy of Dermatology 2013
Reliability of self-reported sun exposure in Canadian women and estimation of lifetime exposure to vitamin D from sun and diet
LS Cook, BL Moon, Y Dong, HK Neilson
Public Health Nutrition 2013
Osteoporosis: Diagnosis and Management
S Silverman, S Venuturupalli
Osteoporosis: Diagnosis and Management 2013
The effect of body mass index on optimal vitamin D status in U.S. adults: The National Health and Nutrition Examination Survey 2001–2006
L Samuel, LN Borrell
Annals of Epidemiology 2013
Protocolo de tratamiento de la deficiencia de vitamina D
FJ Rey
Medicina Clínica 2013
Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism
MD Ruppe, SM de Beur
Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism 2013
Vitamin D and bone health outcomes in older age
TR Hill, TJ Aspray, RM Francis
Proceedings of the Nutrition Society 2013
Nutrition and Type 2 Diabetes: Etiology and Prevention
S Liu, Y Song
Nutrition and Type 2 Diabetes: Etiology and Prevention 2013
Vitamin D and UV exposure in chronic kidney disease
R Krause
Dermato-endocrinology 2013
Seasonal variation in the serum 25-hydroxyvitamin D levels of young and elderly active and inactive adults in São Paulo, Brazil: The São PAulo Vitamin D Evaluation Study (SPADES)
SS Maeda, GL Saraiva, LF Hayashi, MS Cendoroglo, LR Ramos, MP Corrêa, CH de Mesquita, M Lazaretti-Castro
Dermato-endocrinology 2013
Effects of sunlight on behavior and 25-hydroxyvitamin D levels in two species of Old World fruit bats
LO Southworth, MF Holick, TC Chen, TH Kunz
Dermato-endocrinology 2013
Vitamin D status and sun exposure in southeast Asia
H Nimitphong, MF Holick
Dermato-endocrinology 2013
Prevalence of vitamin D deficiency during the summer and its relationship with sun exposure and skin phototype in elderly men living in the tropics
MA Cabral, CN Borges, JM Maia, CA Aires, F Bandeira
Clinical Interventions in Aging 2013
Vitamin D - a systematic literature review for the 5th edition of the Nordic Nutrition Recommendations
C Lamberg-Allardt, M Brustad, HE Meyer, L Steingrimsdottir
Food & Nutrition Research 2013
DHCR7 mutations linked to higher vitamin D status allowed early human migration to northern latitudes
V Kuan, AR Martineau, CJ Griffiths, E Hyppönen, R Walton
BMC Evolutionary Biology 2013
Vitamin D status of older adults of diverse ancestry living in the greater Toronto area
JK Ginter, S Krithika, A Gozdzik, H Hanwell, S Whiting, EJ Parra
BMC geriatrics 2013
Factors affecting vitamin D status in different populations in the city of Sao Paulo, Brazil: the Sao PAulo vitamin D Evaluation Study (SPADES)
SS Maeda, GL Saraiva, IS Kunii, LF Hayashi, MS Cendoroglo, LR Ramos, M Lazaretti-Castro
BMC Endocrine Disorders 2013
Sunlight and other determinants of circulating 25-hydroxyvitamin D levels in black and white participants in a nationwide U.S. study
DM Freedman, EK Cahoon, P Rajaraman, JM Major, MM Doody, BH Alexander, RW Hoffbeck, MG Kimlin, BI Graubard, MS Linet
American Journal of Epidemiology 2013
Clinical Practice Guidelines for Healthy Eating for the Prevention and Treatment of Metabolic and Endocrine Diseases in Adults: Cosponsored by The American Association of Clinical Endocrinologists/The American College of Endocrinology and The Obesity Society
JM Gonzalez-Campoy, ST st. Jeor, K Castorino, A Ebrahim, D Hurley, L Jovanovic, JI Mechanick, SM Petak, YH Yu, KA Harris, P Kris-Etherton, R Kushner, M Molini-Blandford, QT Nguyen, R Plodkowski, DB Sarwer, KT Thomas
Endocrine Practice 2013
Low vitamin D status is associated with reduced muscle mass and impaired physical performance in frail elderly people
M Tieland, EM Brouwer-Brolsma, C Nienaber-Rousseau, LJ van Loon, LC de Groot
European Journal of Clinical Nutrition 2013
Impact of seasonal and geographical differences on breast cancer survival
HW Kwon, JW Lee, HJ Kim, BS Koh, JH Yu, JW Lee, BH Son, SH Ahn
Korean Journal of Clinical Oncology 2013
Prevalence of Vitamin D Deficiency and Association with Functional Status in Newly Admitted Male Veteran Nursing Home Residents
G Kojima, A Tamai, K Masaki, G Gatchell, J Epure, C China, GW Ross, H Petrovitch, M Tanabe
Journal of the American Geriatrics Society 2013
Solar ultraviolet radiation in South Africa: clinical consequences for the skin
CY Wright, LM Davids, B Summers, M Norval
Expert Review of Dermatology 2013
Analysis of vitamin D metabolic markers by mass spectrometry: Current techniques, limitations of the “gold standard” method, and anticipated future directions: MEASURING VITAMIN D METABOLIC MARKERS BY MASS SPECTROMETRY
DA Volmer, LR Mendes, CS Stokes
Mass Spectrometry Reviews 2013
Vitamin D and maternal and child health: Overview and implications for dietary requirements: Vitamin D and Maternal and Child Health
JY Uriu-Adams, SG Obican, CL Keen
Birth Defects Research Part C Embryo Today Reviews 2013
Quality of dietary intake in relation to body composition in patients with chronic obstructive pulmonary disease eligible for pulmonary rehabilitation
C de Bool, C Mattijssen-Verdonschot, PP van Melick, MA Spruit, FM Franssen, EF Wouters, AM Schols, EP Rutten
European Journal of Clinical Nutrition 2013
Vitamin D and Cardiovascular Disease: An Appraisal of the Evidence
PF Schnatz, JE Manson
Clinical chemistry 2013
Bisphosphonates and adipogenesis: Evidence for alendronate inhibition of adipocyte differentiation in 3T3-L1 preadipocytes through a vitamin D receptor mediated effect
C Mammi, M Calanchini, A Antelmi, A Feraco, L Gnessi, S Falcone, F Quintarelli, GM Rosano, A Fabbri, M Caprio
Natural Science 2013
Less than Adequate Vitamin D Status and Intake in Latin America and the Caribbean: A Problem of Unknown Magnitude
A Brito, H Cori, M Olivares, MF Mujica, G Cediel, DL de Romaña
Food and nutrition bulletin 2013
Influence of altitude on vitamin D and bone metabolism of lactating sheep and goats1
M Kohler, F Leiber, H Willems, L Merbold, A Liesegang
Journal of animal science 2013
Prevalence of Vitamin D Deficiency Among Patients After Kidney Transplantation in Latvia
I Ādamsone, I Folkmane, D Amerika, R Rozentāls
Proceedings of the Latvian Academy of Sciences Section B Natural Exact and Applied Sciences 2013
Prevalence of Vitamin D Insufficiency and Associated Factors Among Canadian Cree: A Cross-sectional Study
B Riverin, E Dewailly, S Côté, L Johnson-Down, S Morin, S Dodin
Canadian journal of public health. Revue canadienne de sante publique 2013
Diet Quality
VR Preedy, LA Hunter, VB Patel
2013
Building healthy bones throughout life: an evidence‐informed strategy to prevent osteoporosis in Australia
PR Ebeling, RM Daly, DA Kerr, MG Kimlin
The Medical Journal of Australia 2013
High serum vitamin D levels reduce the risk for nonalcoholic fatty liver disease in healthy men independent of metabolic syndrome
EJ Rhee, MK Kim, SE Park, CY Park, KH Baek, WY Lee, MI Kang, SW Park, SW Kim, KW Oh
Endocrine Journal 2013
Quality of dietary intake in relation to body composition in patients with chronic obstructive pulmonary disease eligible for pulmonary rehabilitation
C van de Bool, C Mattijssen-Verdonschot, PP van Melick, MA Spruit, FM Franssen, EF Wouters, AM Schols, EP Rutten
European Journal of Clinical Nutrition 2013
Predictors of vitamin D deficiency and insufficiency in adult Bahrainis: a cross-sectional study.
Golbahar J, Al-Saffar N, Altayab Diab D, Al-Othman S, Darwish A, Al-Kafaji G
Public Health Nutrition 2013
Reliability of self-reported sun exposure in Canadian women and estimation of lifetime exposure to vitamin D from sun and diet.
Cook LS, Moon BL, Dong Y, Neilson HK
Public Health Nutrition 2013

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