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J MacLaughlin, M F Holick
Published October 1, 1985
Citation Information: J Clin Invest. 1985;76(4):1536-1538. https://doi.org/10.1172/JCI112134.
Citation Information: J Clin Invest. 1985;76(4):1536-1538. https://doi.org/10.1172/JCI112134.
Abstract
An evaluation of surgically obtained skin (age range, 8-92 yr) revealed that there is an age-dependent decrease in the epidermal concentrations of provitamin D3 (7-dehydrocholesterol). To ascertain that aging indeed decreased the capacity of human skin to produce vitamin D3, some of the skin samples were exposed to ultraviolet radiation and the content of previtamin D3 was determined in the epidermis and dermis. The epidermis in the young and older subjects was the major site for the formation of previtamin D3, accounting for greater than 80% of the total previtamin D3 that was produced in the skin. A comparison of the amount of previtamin D3 produced in the skin from the 8- and 18-yr-old subjects with the amount produced in the skin from the 77- and 82-yr-old subjects revealed that aging can decrease by greater than twofold the capacity of the skin to produce previtamin D3. Recognition of this difference may be extremely important for the elderly, who infrequently expose a small area of skin to sunlight and who depend on this exposure for their vitamin D nutritional needs.
Authors
J MacLaughlin, M F Holick
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Citation information
Citations to this article in year 2017 (49)
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|---|---|---|
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MJ Berridge |
The Journal of Physiology | 2017 |
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Ultraviolet Light in Human Health, Diseases and Environment
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Ultraviolet Light in Human Health, Diseases and Environment | 2017 |
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Ultraviolet Light in Human Health, Diseases and Environment
SI Ahmad |
Ultraviolet Light in Human Health, Diseases and Environment | 2017 |
|
Vitamin D levels and deficiency with different occupations: a systematic review
D Sowah, X Fan, L Dennett, R Hagtvedt, S Straube |
BMC Public Health | 2017 |
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Textbook of Aging Skin
G Nikolakis, E Makrantonaki, CC Zouboulis |
Textbook of Aging Skin | 2017 |
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Vitamin D in autoimmune rheumatic diseases: A view inside gender differences
M Vasile, C Corinaldesi, C Antinozzi, C Crescioli |
Pharmacological Research | 2017 |
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Comparative analysis of nutritional guidelines for vitamin D
R Bouillon |
Nature Reviews Endocrinology | 2017 |
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Associations of vitamin D status with dietary intakes and physical activity levels among adults from seven European countries: the Food4Me study
Y Manios, G Moschonis, CP Lambrinou, C Mavrogianni, L Tsirigoti, U Hoeller, FF Roos, I Bendik, M Eggersdorfer, C Celis-Morales, KM Livingstone, CF Marsaux, AL Macready, R Fallaize, CB ODonovan, C Woolhead, H Forster, MC Walsh, S Navas-Carretero, R San-Cristobal, S Kolossa, J Hallmann, M Jarosz, A Surwiłło, I Traczyk, CA Drevon, B Ommen, K Grimaldi, JN Matthews, H Daniel, JA Martinez, JA Lovegrove, ER Gibney, L Brennan, WH Saris, M Gibney, JC Mathers |
European Journal of Nutrition | 2017 |
|
Prevalence and predictors of hypovitaminosis D among the elderly in subtropical region
CH Huang, YT Huang, YC Lai, CK Sun, S Kaser |
PloS one | 2017 |
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Vitamin D: Correlation with biochemical and body composition changes in a southern Brazilian population and induction of cytotoxicity in mesenchymal stem cells derived from human adipose tissue
JR Pesarini, RJ Oliveira, LR Pessatto, AC Antoniolli-Silva, I Felicidade, NB Nardi, M Camassola, MS Mantovani, LR Ribeiro |
Biomedicine & Pharmacotherapy | 2017 |
|
Calcium and vitamin-D deficiency marginally impairs fracture healing but aggravates posttraumatic bone loss in osteoporotic mice
V Fischer, M Haffner-Luntzer, K Prystaz, A Scheidt, B Busse, T Schinke, M Amling, A Ignatius |
Scientific Reports | 2017 |
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Daily Routine in Cosmetic Dermatology
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Daily Routine in Cosmetic Dermatology | 2017 |
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Handbook of Famine, Starvation, and Nutrient Deprivation
V Preedy, VB Patel |
Handbook of Famine, Starvation, and Nutrient Deprivation | 2017 |
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Effects of chronic endurance exercise training on serum 25(OH)D concentrations in elderly Japanese men
X Sun, ZB Cao, K Tanisawa, H Taniguchi, T Kubo, M Higuchi |
Endocrine | 2017 |
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The role of vitamin D in maintaining bone health in older people
TR Hill, TJ Aspray |
Therapeutic Advances in Musculoskeletal Diseases | 2017 |
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Handbook of Immunosenescence
T Fulop, C Franceschi, K Hirokawa, G Pawelec |
Handbook of Immunosenescence | 2017 |
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Calcium and Vitamin D in Human Health: Hype or Real?
SJ Wimalawansa, DS Razzaque, NM Al-Daghri |
The Journal of Steroid Biochemistry and Molecular Biology | 2017 |
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Is there a role for vitamin D in supporting cognitive function as we age?
N Aspell, B Lawlor, M O'Sullivan |
Proceedings of the Nutrition Society | 2017 |
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Principles and Practice of Geriatric Surgery
RA Rosenthal, ME Zenilman, MR Katlic |
2017 | |
|
Sunlight exposure is just one of the factors which influence vitamin D status
M Abboud, MS Rybchyn, R Rizk, DR Fraser, RS Mason |
Photochemical & Photobiological Sciences | 2017 |
|
Evidence-based guidelines for fall prevention in Korea
KI Kim, HK Jung, CO Kim, SK Kim, HH Cho, DY Kim, YC Ha, SH Hwang, CW Won, JY Lim, HJ Kim, JG Kim |
The Korean Journal of Internal Medicine | 2017 |
|
Dietary factors and polymorphisms in vitamin D metabolism genes: the risk and prognosis of colorectal cancer in northeast China
C Gong, Z Long, Y Yu, L Zhu, J Tian, S Li, J Li, H Yu, Q Chi, D Piao, F Wang, Y Zhao, B Cui |
Scientific Reports | 2017 |
|
Determination of Vitamin D Status in a Population of Ecuadorian Subjects
G Maldonado, C Paredes, R Guerrero, C Ríos |
The Scientific World JOURNAL | 2017 |
|
Prevalence and Determinants of Suboptimal Vitamin D Levels in a Multiethnic Asian Population
R Man, LJ Li, CY Cheng, T Wong, E Lamoureux, C Sabanayagam |
Nutrients | 2017 |
|
Relationship of very low serum 25-hydroxyvitamin D3 levels with long-term survival in a large cohort of colorectal cancer patients from Germany
H Maalmi, V Walter, L Jansen, J Chang-Claude, RW Owen, A Ulrich, B Schöttker, M Hoffmeister, H Brenner |
European Journal of Epidemiology | 2017 |
|
Vitamin D, Calcium, and Cardiovascular Disease: A“D”vantageous or “D”etrimental? An Era of Uncertainty
K Chin, LJ Appel, ED Michos |
Current Atherosclerosis Reports | 2017 |
|
The relationship between cumulative lifetime ultraviolet radiation exposure, bone mineral density, falls risk and fractures in older adults
MJ Thompson, DA Aitken, P Otahal, J Cicolini, TM Winzenberg, G Jones |
Osteoporosis International | 2017 |
|
Longitudinal changes in serum 25-hydroxyvitamin D in the Dallas Heart Study
S Mirfakhraee, CR Ayers, DK McGuire, NM Maalouf |
Clinical Endocrinology | 2017 |
|
UV irradiation to mouse skin decreases hippocampal neurogenesis and synaptic protein expression via HPA axis activation
M Han, JJ Ban, JS Bae, CY Shin, DH Lee, JH Chung |
Scientific Reports | 2017 |
|
Vitamin D status and its association with insulin resistance among type 2 diabetics: A case -control study in Ghana
LA Fondjo, WK Owiredu, SA Sakyi, EF Laing, MA Adotey-Kwofie, EO Antoh, E Detoh, C Hu |
PloS one | 2017 |
|
Vitamin D status and associated factors among Portuguese older adults: results from the Nutrition UP 65 cross-sectional study
A Santos, TF Amaral, RS Guerra, AS Sousa, L Álvares, P Moreira, P Padrão, C Afonso, N Borges |
BMJ Open | 2017 |
|
Dose–response effects of supplementation with calcifediol on serum 25-hydroxyvitamin D status and its metabolites: A randomized controlled trial in older adults
AM Vaes, M Tieland, MF de Regt, J Wittwer, LJ van Loon, LC de Groot |
Clinical nutrition (Edinburgh, Scotland) | 2017 |
|
Spatiotemporal analysis of tuberculosis incidence and its associated factors in mainland China
C GUO, Y DU, SQ Shen, XQ Lao, J QIAN, CQ Ou |
Epidemiology and Infection | 2017 |
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Vitamin D-related Nutrigenetics and Cognitive Decline in an Elderly Population
C Martin, Z Yates, M Veysey, K King, S Niblett, M Lucock |
2017 | |
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Non-ionizing Radiation Protection: Summary of Research and Policy Options
AW Wood, K Karipidis |
2017 | |
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Association of UV radiation with Parkinson disease incidence: A nationwide French ecologic study
A Kravietz, S Kab, L Wald, A Dugravot, A Singh-Manoux, F Moisan, A Elbaz |
Environmental Research | 2017 |
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Vitamin D status and cardiometabolic risk factors across latitudinal gradient in Iranian adults: National food and nutrition surveillance
B Nikooyeh, Z Abdollahi, M Hajifaraji, H Alavi-majd, F Salehi, AH Yarparvar, TR Neyestani |
Nutrition and Health | 2017 |
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The Prevalence of Vitamin D Deficiency and the Determinants of 25(OH)D Concentration in Older Irish Adults: Data From The Irish Longitudinal Study on Ageing (TILDA)
E Laird, AM OHalloran, D Carey, M Healy, D OConnor, P Moore, T Shannon, AM Molloy, RA Kenny |
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences | 2017 |
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Seasonal variation of serum vitamin D levels in Romania
DA Niculescu, CA Capatina, R Dusceac, A Caragheorgheopol, A Ghemigian, C Poiana |
Archives of Osteoporosis | 2017 |
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A Solution-Processable, Omnidirectionally Stretchable, and High-Pressure-Sensitive Piezoresistive Device
E Roh, HB Lee, DI Kim, NE Lee |
Advanced materials (Deerfield Beach, Fla.) | 2017 |
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Relationship between skin color, sun exposure, UV protection, fish intake and serum levels of vitamin D in Japanese older adults
MM Cabral, AJ Bos, H Amano, S Seino, S Shinkai |
Nutrition & Food Science | 2017 |
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Optimal Vitamin D Status in a Middle-Aged and Elderly Population Residing in Shanghai, China
Qiqige Aleteng, Lin Zhao, Huandong Lin, Mingfeng Xia, Hui Ma, Jian Gao, Baishen Pan, Xin Gao |
Medical science monitor : international medical journal of experimental and clinical research | 2017 |
|
Skin Diseases in the Immunosuppressed
OR Colegio |
2017 | |
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Vitamin-D-Mangel in der Schweizer Sonnenstube?
MC Quarenghi, E Aubry, C Aeberhard, N Ossola, C Marone, Z Stanga |
Praxis | 2017 |
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Causes of elevated parathyroid hormone levels in postmenopausal women
I Esen, SA Esen, S Cander, OO Gul, G Ocakoglu, E Erturk |
2017 | |
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VITAMIN D DEFICIENCY IN JAMMU IN SUBJECTS WITH NO COMORBIDITY- A PRELIMINARY STUDY
S Kapoor |
2017 | |
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Effect of vitamin D3 in treating hyperthyroidism in patients with graves’ disease
NA Sheriba, AA Elewa, MM Mahdy, AM Din, NA Ibrahim, DA Marawan, TM Moneim |
2017 | |
|
Associations of vitamin D status with dietary intakes and physical activity levels among adults from seven European countries: the Food4Me study
Y Manios, G Moschonis, CP Lambrinou, C Mavrogianni, L Tsirigoti, U Hoeller, FF Roos, I Bendik, M Eggersdorfer, C Celis-Morales, KM Livingstone, CF Marsaux, AL Macready, R Fallaize, CB ODonovan, C Woolhead, H Forster, MC Walsh, S Navas-Carretero, R San-Cristobal, S Kolossa, J Hallmann, M Jarosz, A Surwiłło, I Traczyk, CA Drevon, B van Ommen, K Grimaldi, JN Matthews, H Daniel, JA Martinez, JA Lovegrove, ER Gibney, L Brennan, WH Saris, M Gibney, JC Mathers |
European Journal of Nutrition | 2017 |
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Spatiotemporal analysis of tuberculosis incidence and its associated factors in mainland China.
Guo C, Du Y, Shen SQ, Lao XQ, Qian J, Ou CQ |
Epidemiology and Infection | 2017 |
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