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Citations to this article

Aging decreases the capacity of human skin to produce vitamin D3.
J MacLaughlin, M F Holick
J MacLaughlin, M F Holick
Published October 1, 1985
Citation Information: J Clin Invest. 1985;76(4):1536-1538. https://doi.org/10.1172/JCI112134.
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Research Article Article has an altmetric score of 135

Aging decreases the capacity of human skin to produce vitamin D3.

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Abstract

An evaluation of surgically obtained skin (age range, 8-92 yr) revealed that there is an age-dependent decrease in the epidermal concentrations of provitamin D3 (7-dehydrocholesterol). To ascertain that aging indeed decreased the capacity of human skin to produce vitamin D3, some of the skin samples were exposed to ultraviolet radiation and the content of previtamin D3 was determined in the epidermis and dermis. The epidermis in the young and older subjects was the major site for the formation of previtamin D3, accounting for greater than 80% of the total previtamin D3 that was produced in the skin. A comparison of the amount of previtamin D3 produced in the skin from the 8- and 18-yr-old subjects with the amount produced in the skin from the 77- and 82-yr-old subjects revealed that aging can decrease by greater than twofold the capacity of the skin to produce previtamin D3. Recognition of this difference may be extremely important for the elderly, who infrequently expose a small area of skin to sunlight and who depend on this exposure for their vitamin D nutritional needs.

Authors

J MacLaughlin, M F Holick

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 1989 1988 1987 1986 1985 1981 1971 Total
Citations: 6 25 14 29 43 60 33 38 49 47 50 47 57 40 49 47 42 30 28 32 25 14 15 11 7 11 15 10 15 2 7 5 10 4 4 7 11 5 4 2 1 1 1 953
Citation information
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Citations to this article in year 2020 (60)

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J Reichrath
2020
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2020
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2020
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2020
Vitamin D deficiency as a potential risk factor for accelerated aging, impaired hippocampal neurogenesis and cognitive decline: a role for Wnt/β-catenin signaling
R Gómez-Oliva, N Geribaldi-Doldán, S Domínguez-García, L Carrascal, C Verástegui, P Nunez-Abades, C Castro
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