Issue published September 1, 1997 Previous issue | Next issue
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Editorial
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W F Rosse
A N SchechterA N SchechterPublished September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):955-956. https://doi.org/10.1172/JCI119646.
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Correction
/articles/view/119598E1Published September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1323-1323. https://doi.org/10.1172/JCI119598E1.
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Research Articles
T Ma, … , C J Epstein, A S VerkmanT Ma, … , C J Epstein, A S VerkmanPublished September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):957-962. https://doi.org/10.1172/JCI231.×Abstract
Research Article
Authors
T Ma, B Yang, A Gillespie, E J Carlson, C J Epstein, A S Verkman
C M Lloyd, … , J Just, J C Gutierrez-RamosC M Lloyd, … , J Just, J C Gutierrez-RamosPublished September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):963-971. https://doi.org/10.1172/JCI119647.×Abstract
Research Article
Authors
C M Lloyd, J A Gonzalo, D J Salant, J Just, J C Gutierrez-Ramos
H Böhrer, … , E Martin, P P NawrothH Böhrer, … , E Martin, P P NawrothPublished September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):972-985. https://doi.org/10.1172/JCI119648.×Abstract
Research Article
Authors
H Böhrer, F Qiu, T Zimmermann, Y Zhang, T Jllmer, D Männel, B W Böttiger, D M Stern, R Waldherr, H D Saeger, R Ziegler, A Bierhaus, E Martin, P P Nawroth
E Carballo, … , G S Gilkeson, P J BlackshearE Carballo, … , G S Gilkeson, P J BlackshearPublished September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):986-995. https://doi.org/10.1172/JCI119649.×Abstract
Research Article
Authors
E Carballo, G S Gilkeson, P J Blackshear
J I Elizalde, … , D N Granger, J M PiquéJ I Elizalde, … , D N Granger, J M PiquéPublished September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):996-1005. https://doi.org/10.1172/JCI119650.×Abstract
Research Article
Authors
J I Elizalde, J Gómez, J Panés, M Lozano, M Casadevall, J Ramírez, P Pizcueta, F Marco, F D Rojas, D N Granger, J M Piqué
S Kim, … , J M Leiden, M S ParmacekS Kim, … , J M Leiden, M S ParmacekPublished September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1006-1014. https://doi.org/10.1172/JCI119611.×Abstract
Research Article
Authors
S Kim, H Lin, E Barr, L Chu, J M Leiden, M S Parmacek
A Panoskaltsis-Mortari, … , D A Vallera, B R BlazarA Panoskaltsis-Mortari, … , D A Vallera, B R BlazarPublished September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1015-1027. https://doi.org/10.1172/JCI119612.×Abstract
Research Article
Authors
A Panoskaltsis-Mortari, P A Taylor, T M Yaeger, O D Wangensteen, P B Bitterman, D H Ingbar, D A Vallera, B R Blazar
V Rosti, … , L Luzzatto, M BesslerV Rosti, … , L Luzzatto, M BesslerPublished September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1028-1036. https://doi.org/10.1172/JCI119613.×Abstract
Research Article
Authors
V Rosti, G Tremml, V Soares, P P Pandolfi, L Luzzatto, M Bessler
R Seensalu, … , L Slice, J H WalshR Seensalu, … , L Slice, J H WalshPublished September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1037-1046. https://doi.org/10.1172/JCI119614.×Abstract
Research Article
Authors
R Seensalu, D Avedian, R Barbuti, M Song, L Slice, J H Walsh
G Wolf, … , U Helmchen, R A StahlG Wolf, … , U Helmchen, R A StahlPublished September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1047-1058. https://doi.org/10.1172/JCI119615.×Abstract
Research Article
Authors
G Wolf, F N Ziyadeh, F Thaiss, J Tomaszewski, R J Caron, U Wenzel, G Zahner, U Helmchen, R A Stahl
J Wu, … , J E Salmon, R P KimberlyJ Wu, … , J E Salmon, R P KimberlyPublished September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1059-1070. https://doi.org/10.1172/JCI119616.×Abstract
Research Article
Authors
J Wu, J C Edberg, P B Redecha, V Bansal, P M Guyre, K Coleman, J E Salmon, R P Kimberly
E P Carter, … , M A Matthay, A S VerkmanE P Carter, … , M A Matthay, A S VerkmanPublished September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1071-1078. https://doi.org/10.1172/JCI119617.×Abstract
Research Article
Authors
E P Carter, F Umenishi, M A Matthay, A S Verkman
X Xiong, … , J Cohn, W R SkachX Xiong, … , J Cohn, W R SkachPublished September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1079-1088. https://doi.org/10.1172/JCI119618.×Abstract
Research Article
Authors
X Xiong, A Bragin, J H Widdicombe, J Cohn, W R Skach
Q Xu, … , R Kleindienst, G WickQ Xu, … , R Kleindienst, G WickPublished September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1089-1097. https://doi.org/10.1172/JCI119619.×Abstract
Research Article
Authors
Q Xu, Y Hu, R Kleindienst, G Wick
J P Revelli, … , J Huarte, C OdyJ P Revelli, … , J Huarte, C OdyPublished September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1098-1106. https://doi.org/10.1172/JCI119620.×Abstract
Research Article
Authors
J P Revelli, F Preitner, S Samec, P Muniesa, F Kuehne, O Boss, J D Vassalli, A Dulloo, J Seydoux, J P Giacobino, J Huarte, C Ody
G Boden, … , J W Kolaczynski, M PolanskyG Boden, … , J W Kolaczynski, M PolanskyPublished September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1107-1113. https://doi.org/10.1172/JCI119621.×Abstract
Research Article
Authors
G Boden, X Chen, J W Kolaczynski, M Polansky
K W Wucherpfennig, … , L Steinman, K G WarrenK W Wucherpfennig, … , L Steinman, K G WarrenPublished September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1114-1122. https://doi.org/10.1172/JCI119622.×Abstract
Research Article
Authors
K W Wucherpfennig, I Catz, S Hausmann, J L Strominger, L Steinman, K G Warren
K Thankavel, … , P M Arumugam, S N AbrahamK Thankavel, … , P M Arumugam, S N AbrahamPublished September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1123-1136. https://doi.org/10.1172/JCI119623.×Abstract
Research Article
Authors
K Thankavel, B Madison, T Ikeda, R Malaviya, A H Shah, P M Arumugam, S N Abraham
M Uguccioni, … , M Baggiolini, C A DahindenM Uguccioni, … , M Baggiolini, C A DahindenPublished September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1137-1143. https://doi.org/10.1172/JCI119624.×Abstract
Research Article
Authors
M Uguccioni, C R Mackay, B Ochensberger, P Loetscher, S Rhis, G J LaRosa, P Rao, P D Ponath, M Baggiolini, C A Dahinden
J Zabner, … , A Fabrega, M J WelshJ Zabner, … , A Fabrega, M J WelshPublished September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1144-1149. https://doi.org/10.1172/JCI119625.×Abstract
Research Article
Authors
J Zabner, P Freimuth, A Puga, A Fabrega, M J Welsh
M Bustos, … , S Saadi, J L PlattM Bustos, … , S Saadi, J L PlattPublished September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1150-1158. https://doi.org/10.1172/JCI119626.×Abstract
Research Article
Authors
M Bustos, T M Coffman, S Saadi, J L Platt
Y Takahashi, … , T Tanaka, K ChiharaY Takahashi, … , T Tanaka, K ChiharaPublished September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1159-1165. https://doi.org/10.1172/JCI119627.×Abstract
Research Article
Authors
Y Takahashi, H Shirono, O Arisaka, K Takahashi, T Yagi, J Koga, H Kaji, Y Okimura, H Abe, T Tanaka, K Chihara
Ele Ferrannini, … , Nebojsa Lalic, Gertrude MingroneEle Ferrannini, … , Nebojsa Lalic, Gertrude MingronePublished September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1166-1173. https://doi.org/10.1172/JCI119628.×Abstract
Insulin resistance and insulin hypersecretion are established features of obesity. Their prevalence, however, has only been inferred from plasma insulin concentrations. We measured insulin sensitivity (as the whole-body insulin-mediated glucose uptake) and fasting posthepatic insulin delivery rate (IDR) with the use of the euglycemic insulin clamp technique in a large group of obese subjects in the database of the European Group for the Study of Insulin Resistance (1,146 nondiabetic, normotensive Caucasian men and women aged 18-85 yr, with a body mass index (BMI) ranging from 15 to 55 kg.m-2). Insulin resistance, defined as the lowest decile of insulin sensitivity in the lean subgroup (608 subjects with a mean BMI of 29 kg.m-2). Insulin sensitivity declined linearly with BMI at an age- and sex-adjusted rate of 1.2 micromol.min-1.kg FFM-1 per BMI unit (95% confidence intervals = 1.0-1.4). Insulin hypersecretion, defined as the upper decile of IDR, was significantly (P<0.0001) more prevalent (38%) than insulin resistance in the obese group. In the whole dataset, IDR rose as a function of both BMI and insulin resistance in a nonlinear fashion. Neither the waist circumference nor the waist-to-hip ratio, indices of body fat distribution, was related to insulin sensitivity after adjustment for age, gender, and BMI; both, however, were positively associated (P<0.001) with insulin hypersecretion, particularly in women. In nondiabetic, normotensive obese subjects, the prevalence of insulin resistance is relatively low, and is exceeded by the prevalence of insulin hypersecretion, particularly in women with central obesity. In the obese with preserved insulin sensitivity, risk for diabetes, cardiovascular risk, and response to treatment may be different than in insulin resistant obesity.
Authors
Ele Ferrannini, Andrea Natali, Patrick Bell, Paolo Cavallo-Perin, Nebojsa Lalic, Gertrude Mingrone
N G Chen, … , A G Swick, D R RomsosN G Chen, … , A G Swick, D R RomsosPublished September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1174-1179. https://doi.org/10.1172/JCI119629.×Abstract
Research Article
Authors
N G Chen, A G Swick, D R Romsos
K Tang, … , R J Parmer, D T O'ConnorK Tang, … , R J Parmer, D T O'ConnorPublished September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1180-1192. https://doi.org/10.1172/JCI119630.×Abstract
Research Article
Authors
K Tang, H Wu, S K Mahata, M Mahata, B M Gill, R J Parmer, D T O'Connor
C A Head, … , K D Bloch, W M ZapolC A Head, … , K D Bloch, W M ZapolPublished September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1193-1198. https://doi.org/10.1172/JCI119631.×Abstract
Research Article
Authors
C A Head, C Brugnara, R Martinez-Ruiz, R M Kacmarek, K R Bridges, D Kuter, K D Bloch, W M Zapol
M Takada, … , M H Sayegh, N L TilneyM Takada, … , M H Sayegh, N L TilneyPublished September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1199-1203. https://doi.org/10.1172/JCI119632.×Abstract
Research Article
Authors
M Takada, A Chandraker, K C Nadeau, M H Sayegh, N L Tilney
L S Rott, … , H B Greenberg, E C ButcherL S Rott, … , H B Greenberg, E C ButcherPublished September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1204-1208. https://doi.org/10.1172/JCI119633.×Abstract
Research Article
Authors
L S Rott, J R Rosé, D Bass, M B Williams, H B Greenberg, E C Butcher
K Ishikawa, … , A M Fogelman, A J LusisK Ishikawa, … , A M Fogelman, A J LusisPublished September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1209-1216. https://doi.org/10.1172/JCI119634.×Abstract
Research Article
Authors
K Ishikawa, M Navab, N Leitinger, A M Fogelman, A J Lusis
Z Zheng, … , P E Pummill, P W KincadeZ Zheng, … , P E Pummill, P W KincadePublished September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1217-1229. https://doi.org/10.1172/JCI119635.×Abstract
Research Article
Authors
Z Zheng, R D Cummings, P E Pummill, P W Kincade
H O Steinberg, … , B Bayazeed, A D BaronH O Steinberg, … , B Bayazeed, A D BaronPublished September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1230-1239. https://doi.org/10.1172/JCI119636.×Abstract
Research Article
Authors
H O Steinberg, M Tarshoby, R Monestel, G Hook, J Cronin, A Johnson, B Bayazeed, A D Baron
A V Lembertas, … , A J Lusis, C BouchardA V Lembertas, … , A J Lusis, C BouchardPublished September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1240-1247. https://doi.org/10.1172/JCI119637.×Abstract
Research Article
Authors
A V Lembertas, L Pérusse, Y C Chagnon, J S Fisler, C H Warden, D A Purcell-Huynh, F T Dionne, J Gagnon, A Nadeau, A J Lusis, C Bouchard
L I Brasoveanu, … , M Altomonte, M MaioL I Brasoveanu, … , M Altomonte, M MaioPublished September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1248-1255. https://doi.org/10.1172/JCI119638.×Abstract
Research Article
Authors
L I Brasoveanu, E Fonsatti, A Visintin, M Pavlovic, I Cattarossi, F Colizzi, A Gasparollo, S Coral, V Horejsi, M Altomonte, M Maio
Z Liu, … , G O Till, L A DiazZ Liu, … , G O Till, L A DiazPublished September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1256-1263. https://doi.org/10.1172/JCI119639.×Abstract
Research Article
Authors
Z Liu, G J Giudice, X Zhou, S J Swartz, J L Troy, J A Fairley, G O Till, L A Diaz
D Sacerdoti, … , A Gatta, J C McGiffD Sacerdoti, … , A Gatta, J C McGiffPublished September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1264-1270. https://doi.org/10.1172/JCI119640.×Abstract
Research Article
Authors
D Sacerdoti, M Balazy, P Angeli, A Gatta, J C McGiff
S Stoll, … , W Garner, J ElderS Stoll, … , W Garner, J ElderPublished September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1271-1281. https://doi.org/10.1172/JCI119641.×Abstract
Research Article
Authors
S Stoll, W Garner, J Elder
M Kavallaris, … , M Haber, S B HorwitzM Kavallaris, … , M Haber, S B HorwitzPublished September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1282-1293. https://doi.org/10.1172/JCI119642.×Abstract
Research Article
Authors
M Kavallaris, D Y Kuo, C A Burkhart, D L Regl, M D Norris, M Haber, S B Horwitz
R von Harsdorf, … , B Nadal-Ginard, S F VatnerR von Harsdorf, … , B Nadal-Ginard, S F VatnerPublished September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1294-1304. https://doi.org/10.1172/JCI119643.×Abstract
Research Article
Authors
R von Harsdorf, J G Edwards, Y T Shen, R K Kudej, R Dietz, L A Leinwand, B Nadal-Ginard, S F Vatner
M K Hellerstein, … , S Turner, A LetscherM K Hellerstein, … , S Turner, A LetscherPublished September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1305-1319. https://doi.org/10.1172/JCI119644.×Hepatic gluconeogenic fluxes and glycogen turnover during fasting in humans. A stable isotope study.
Abstract
Research Article
Authors
M K Hellerstein, R A Neese, P Linfoot, M Christiansen, S Turner, A Letscher
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