Issue published September 1, 1997 Previous issue | Next issue
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Editorials
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Abstract
Editorial
Authors
W F Rosse
A N Schechter Published September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):955-956. https://doi.org/10.1172/JCI119646.
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Research Articles
T Ma, … , C J Epstein, A S Verkman Published September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):957-962. https://doi.org/10.1172/JCI231.
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Research Article
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T Ma, B Yang, A Gillespie, E J Carlson, C J Epstein, A S Verkman
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Research Article
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C M Lloyd, J A Gonzalo, D J Salant, J Just, J C Gutierrez-Ramos
H Böhrer, … , E Martin, P P Nawroth Published September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):972-985. https://doi.org/10.1172/JCI119648.
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Research Article
Authors
H Böhrer, F Qiu, T Zimmermann, Y Zhang, T Jllmer, D Männel, B W Böttiger, D M Stern, R Waldherr, H D Saeger, R Ziegler, A Bierhaus, E Martin, P P Nawroth
E Carballo, … , G S Gilkeson, P J Blackshear Published September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):986-995. https://doi.org/10.1172/JCI119649.
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Research Article
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E Carballo, G S Gilkeson, P J Blackshear
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Research Article
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J I Elizalde, J Gómez, J Panés, M Lozano, M Casadevall, J Ramírez, P Pizcueta, F Marco, F D Rojas, D N Granger, J M Piqué
S Kim, … , J M Leiden, M S Parmacek Published September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1006-1014. https://doi.org/10.1172/JCI119611.
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Research Article
Authors
S Kim, H Lin, E Barr, L Chu, J M Leiden, M S Parmacek
A Panoskaltsis-Mortari, … , D A Vallera, B R Blazar Published September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1015-1027. https://doi.org/10.1172/JCI119612.
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Research Article
Authors
A Panoskaltsis-Mortari, P A Taylor, T M Yaeger, O D Wangensteen, P B Bitterman, D H Ingbar, D A Vallera, B R Blazar
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Research Article
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V Rosti, G Tremml, V Soares, P P Pandolfi, L Luzzatto, M Bessler
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Research Article
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R Seensalu, D Avedian, R Barbuti, M Song, L Slice, J H Walsh
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Research Article
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G Wolf, F N Ziyadeh, F Thaiss, J Tomaszewski, R J Caron, U Wenzel, G Zahner, U Helmchen, R A Stahl
J Wu, … , J E Salmon, R P Kimberly Published September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1059-1070. https://doi.org/10.1172/JCI119616.
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Research Article
Authors
J Wu, J C Edberg, P B Redecha, V Bansal, P M Guyre, K Coleman, J E Salmon, R P Kimberly
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Research Article
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E P Carter, F Umenishi, M A Matthay, A S Verkman
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Research Article
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X Xiong, A Bragin, J H Widdicombe, J Cohn, W R Skach
Q Xu, … , R Kleindienst, G Wick Published September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1089-1097. https://doi.org/10.1172/JCI119619.
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Research Article
Authors
Q Xu, Y Hu, R Kleindienst, G Wick
J P Revelli, … , J Huarte, C Ody Published September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1098-1106. https://doi.org/10.1172/JCI119620.
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Research Article
Authors
J P Revelli, F Preitner, S Samec, P Muniesa, F Kuehne, O Boss, J D Vassalli, A Dulloo, J Seydoux, J P Giacobino, J Huarte, C Ody
G Boden, … , J W Kolaczynski, M Polansky Published September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1107-1113. https://doi.org/10.1172/JCI119621.
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Research Article
Authors
G Boden, X Chen, J W Kolaczynski, M Polansky
K W Wucherpfennig, … , L Steinman, K G Warren Published September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1114-1122. https://doi.org/10.1172/JCI119622.
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Research Article
Authors
K W Wucherpfennig, I Catz, S Hausmann, J L Strominger, L Steinman, K G Warren
K Thankavel, … , P M Arumugam, S N Abraham Published September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1123-1136. https://doi.org/10.1172/JCI119623.
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Research Article
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K Thankavel, B Madison, T Ikeda, R Malaviya, A H Shah, P M Arumugam, S N Abraham
M Uguccioni, … , M Baggiolini, C A Dahinden Published September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1137-1143. https://doi.org/10.1172/JCI119624.
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Research Article
Authors
M Uguccioni, C R Mackay, B Ochensberger, P Loetscher, S Rhis, G J LaRosa, P Rao, P D Ponath, M Baggiolini, C A Dahinden
J Zabner, … , A Fabrega, M J Welsh Published September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1144-1149. https://doi.org/10.1172/JCI119625.
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Research Article
Authors
J Zabner, P Freimuth, A Puga, A Fabrega, M J Welsh
M Bustos, … , S Saadi, J L Platt Published September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1150-1158. https://doi.org/10.1172/JCI119626.
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Research Article
Authors
M Bustos, T M Coffman, S Saadi, J L Platt
Y Takahashi, … , T Tanaka, K Chihara Published September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1159-1165. https://doi.org/10.1172/JCI119627.
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Research Article
Authors
Y Takahashi, H Shirono, O Arisaka, K Takahashi, T Yagi, J Koga, H Kaji, Y Okimura, H Abe, T Tanaka, K Chihara
Ele Ferrannini, … , Nebojsa Lalic, Gertrude Mingrone Published September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1166-1173. https://doi.org/10.1172/JCI119628.
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Insulin resistance and insulin hypersecretion are established features of obesity. Their prevalence, however, has only been inferred from plasma insulin concentrations. We measured insulin sensitivity (as the whole-body insulin-mediated glucose uptake) and fasting posthepatic insulin delivery rate (IDR) with the use of the euglycemic insulin clamp technique in a large group of obese subjects in the database of the European Group for the Study of Insulin Resistance (1,146 nondiabetic, normotensive Caucasian men and women aged 18-85 yr, with a body mass index (BMI) ranging from 15 to 55 kg.m-2). Insulin resistance, defined as the lowest decile of insulin sensitivity in the lean subgroup (608 subjects with a mean BMI of 29 kg.m-2). Insulin sensitivity declined linearly with BMI at an age- and sex-adjusted rate of 1.2 micromol.min-1.kg FFM-1 per BMI unit (95% confidence intervals = 1.0-1.4). Insulin hypersecretion, defined as the upper decile of IDR, was significantly (P<0.0001) more prevalent (38%) than insulin resistance in the obese group. In the whole dataset, IDR rose as a function of both BMI and insulin resistance in a nonlinear fashion. Neither the waist circumference nor the waist-to-hip ratio, indices of body fat distribution, was related to insulin sensitivity after adjustment for age, gender, and BMI; both, however, were positively associated (P<0.001) with insulin hypersecretion, particularly in women. In nondiabetic, normotensive obese subjects, the prevalence of insulin resistance is relatively low, and is exceeded by the prevalence of insulin hypersecretion, particularly in women with central obesity. In the obese with preserved insulin sensitivity, risk for diabetes, cardiovascular risk, and response to treatment may be different than in insulin resistant obesity.
Authors
Ele Ferrannini, Andrea Natali, Patrick Bell, Paolo Cavallo-Perin, Nebojsa Lalic, Gertrude Mingrone
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Research Article
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N G Chen, A G Swick, D R Romsos
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Research Article
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K Tang, H Wu, S K Mahata, M Mahata, B M Gill, R J Parmer, D T O'Connor
C A Head, … , K D Bloch, W M Zapol Published September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1193-1198. https://doi.org/10.1172/JCI119631.
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Research Article
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C A Head, C Brugnara, R Martinez-Ruiz, R M Kacmarek, K R Bridges, D Kuter, K D Bloch, W M Zapol
M Takada, … , M H Sayegh, N L Tilney Published September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1199-1203. https://doi.org/10.1172/JCI119632.
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Research Article
Authors
M Takada, A Chandraker, K C Nadeau, M H Sayegh, N L Tilney
L S Rott, … , H B Greenberg, E C Butcher Published September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1204-1208. https://doi.org/10.1172/JCI119633.
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Research Article
Authors
L S Rott, J R Rosé, D Bass, M B Williams, H B Greenberg, E C Butcher
K Ishikawa, … , A M Fogelman, A J Lusis Published September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1209-1216. https://doi.org/10.1172/JCI119634.
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Research Article
Authors
K Ishikawa, M Navab, N Leitinger, A M Fogelman, A J Lusis
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Research Article
Authors
Z Zheng, R D Cummings, P E Pummill, P W Kincade
H O Steinberg, … , B Bayazeed, A D Baron Published September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1230-1239. https://doi.org/10.1172/JCI119636.
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Research Article
Authors
H O Steinberg, M Tarshoby, R Monestel, G Hook, J Cronin, A Johnson, B Bayazeed, A D Baron
A V Lembertas, … , A J Lusis, C Bouchard Published September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1240-1247. https://doi.org/10.1172/JCI119637.
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Research Article
Authors
A V Lembertas, L Pérusse, Y C Chagnon, J S Fisler, C H Warden, D A Purcell-Huynh, F T Dionne, J Gagnon, A Nadeau, A J Lusis, C Bouchard
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Research Article
Authors
L I Brasoveanu, E Fonsatti, A Visintin, M Pavlovic, I Cattarossi, F Colizzi, A Gasparollo, S Coral, V Horejsi, M Altomonte, M Maio
Z Liu, … , G O Till, L A Diaz Published September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1256-1263. https://doi.org/10.1172/JCI119639.
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Research Article
Authors
Z Liu, G J Giudice, X Zhou, S J Swartz, J L Troy, J A Fairley, G O Till, L A Diaz
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Research Article
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D Sacerdoti, M Balazy, P Angeli, A Gatta, J C McGiff
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Research Article
Authors
S Stoll, W Garner, J Elder
M Kavallaris, … , M Haber, S B Horwitz Published September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1282-1293. https://doi.org/10.1172/JCI119642.
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Research Article
Authors
M Kavallaris, D Y Kuo, C A Burkhart, D L Regl, M D Norris, M Haber, S B Horwitz
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Research Article
Authors
R von Harsdorf, J G Edwards, Y T Shen, R K Kudej, R Dietz, L A Leinwand, B Nadal-Ginard, S F Vatner
M K Hellerstein, … , S Turner, A Letscher Published September 1, 1997
Citation Information: J Clin Invest. 1997;100(5):1305-1319. https://doi.org/10.1172/JCI119644.
×Hepatic gluconeogenic fluxes and glycogen turnover during fasting in humans. A stable isotope study.
Abstract
Research Article
Authors
M K Hellerstein, R A Neese, P Linfoot, M Christiansen, S Turner, A Letscher
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