Issue published September 15, 1997 Previous issue | Next issue

  • Volume 100, Issue 6
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Perspective
Aspirin use and potential mechanisms for colorectal cancer prevention.
C S Williams, … , W Smalley, R N DuBois
C S Williams, … , W Smalley, R N DuBois
Published September 15, 1997
Citation Information: J Clin Invest. 1997;100(6):1325-1329. https://doi.org/10.1172/JCI119651.
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Aspirin use and potential mechanisms for colorectal cancer prevention.

Abstract

Perspective

Authors

C S Williams, W Smalley, R N DuBois

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Research Articles
Proliferative responses to recall antigens are associated with pregnancy outcome in women with a history of recurrent spontaneous abortion.
B L Bermas, J A Hill
B L Bermas, J A Hill
Published September 15, 1997
Citation Information: J Clin Invest. 1997;100(6):1330-1334. https://doi.org/10.1172/JCI119652.
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Hormonal and cellular regulation of Sertoli cell anti-Müllerian hormone production in the postnatal mouse.
L Al-Attar, … , N Josso, R Rey
L Al-Attar, … , N Josso, R Rey
Published September 15, 1997
Citation Information: J Clin Invest. 1997;100(6):1335-1343. https://doi.org/10.1172/JCI119653.
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Hormonal and cellular regulation of Sertoli cell anti-Müllerian hormone production in the postnatal mouse.

Abstract

Research Article

Authors

L Al-Attar, K Noël, M Dutertre, C Belville, M G Forest, P S Burgoyne, N Josso, R Rey

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Metabolically inactive insulin analog prevents type I diabetes in prediabetic NOD mice.
D G Karounos, … , J S Bryson, D A Cohen
D G Karounos, … , J S Bryson, D A Cohen
Published September 15, 1997
Citation Information: J Clin Invest. 1997;100(6):1344-1348. https://doi.org/10.1172/JCI119654.
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Metabolically inactive insulin analog prevents type I diabetes in prediabetic NOD mice.

Abstract

Research Article

Authors

D G Karounos, J S Bryson, D A Cohen

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Role and mechanisms of action of acetylcholine in the regulation of rat cholangiocyte secretory functions.
D Alvaro, … , S S Glaser, A Benedetti
D Alvaro, … , S S Glaser, A Benedetti
Published September 15, 1997
Citation Information: J Clin Invest. 1997;100(6):1349-1362. https://doi.org/10.1172/JCI119655.
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Role and mechanisms of action of acetylcholine in the regulation of rat cholangiocyte secretory functions.

Abstract

Research Article

Authors

D Alvaro, G Alpini, A M Jezequel, C Bassotti, C Francia, F Fraioli, R Romeo, L Marucci, G Le Sage, S S Glaser, A Benedetti

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Myocyte apoptosis during acute myocardial infarction in the mouse localizes to hypoxic regions but occurs independently of p53.
S Bialik, … , C J Koch, R N Kitsis
S Bialik, … , C J Koch, R N Kitsis
Published September 15, 1997
Citation Information: J Clin Invest. 1997;100(6):1363-1372. https://doi.org/10.1172/JCI119656.
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Myocyte apoptosis during acute myocardial infarction in the mouse localizes to hypoxic regions but occurs independently of p53.

Abstract

Research Article

Authors

S Bialik, D L Geenen, I E Sasson, R Cheng, J W Horner, S M Evans, E M Lord, C J Koch, R N Kitsis

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Genetic susceptibility to hypertension-induced renal damage in the rat. Evidence based on kidney-specific genome transfer.
P C Churchill, … , N Wang, T W Kurtz
P C Churchill, … , N Wang, T W Kurtz
Published September 15, 1997
Citation Information: J Clin Invest. 1997;100(6):1373-1382. https://doi.org/10.1172/JCI119657.
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Genetic susceptibility to hypertension-induced renal damage in the rat. Evidence based on kidney-specific genome transfer.

Abstract

Research Article

Authors

P C Churchill, M C Churchill, A K Bidani, K A Griffin, M Picken, M Pravenec, V Kren, E St Lezin, J M Wang, N Wang, T W Kurtz

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Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2.
C U Corvera, … , D G Payan, N W Bunnett
C U Corvera, … , D G Payan, N W Bunnett
Published September 15, 1997
Citation Information: J Clin Invest. 1997;100(6):1383-1393. https://doi.org/10.1172/JCI119658.
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Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2.

Abstract

Research Article

Authors

C U Corvera, O Déry, K McConalogue, S K Böhm, L M Khitin, G H Caughey, D G Payan, N W Bunnett

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Creation of an In vivo cytosensor using engineered mesangial cells. Automatic sensing of glomerular inflammation controls transgene activity.
M Kitamura, H Kawachi
M Kitamura, H Kawachi
Published September 15, 1997
Citation Information: J Clin Invest. 1997;100(6):1394-1399. https://doi.org/10.1172/JCI119659.
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Hepatic function in a family with a nonsense mutation (R154X) in the hepatocyte nuclear factor-4alpha/MODY1 gene.
T Lindner, … , J Schulze, G I Bell
T Lindner, … , J Schulze, G I Bell
Published September 15, 1997
Citation Information: J Clin Invest. 1997;100(6):1400-1405. https://doi.org/10.1172/JCI119660.
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Hepatic function in a family with a nonsense mutation (R154X) in the hepatocyte nuclear factor-4alpha/MODY1 gene.

Abstract

Research Article

Authors

T Lindner, C Gragnoli, H Furuta, B N Cockburn, C Petzold, H Rietzsch, U Weiss, J Schulze, G I Bell

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Angiotensinogen T235 expression is elevated in decidual spiral arteries.
T Morgan, … , J M Lalouel, K Ward
T Morgan, … , J M Lalouel, K Ward
Published September 15, 1997
Citation Information: J Clin Invest. 1997;100(6):1406-1415. https://doi.org/10.1172/JCI119661.
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Angiotensinogen T235 expression is elevated in decidual spiral arteries.

Abstract

Research Article

Authors

T Morgan, C Craven, L Nelson, J M Lalouel, K Ward

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Antineutrophil cytoplasmic antibodies induce monocyte IL-8 release. Role of surface proteinase-3, alpha1-antitrypsin, and Fcgamma receptors.
D R Ralston, … , M P Lowe, M D Wewers
D R Ralston, … , M P Lowe, M D Wewers
Published September 15, 1997
Citation Information: J Clin Invest. 1997;100(6):1416-1424. https://doi.org/10.1172/JCI119662.
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Targeted overexpression of IGF-I evokes distinct patterns of organ remodeling in smooth muscle cell tissue beds of transgenic mice.
J Wang, … , A Strauch, J A Fagin
J Wang, … , A Strauch, J A Fagin
Published September 15, 1997
Citation Information: J Clin Invest. 1997;100(6):1425-1439. https://doi.org/10.1172/JCI119663.
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Targeted overexpression of IGF-I evokes distinct patterns of organ remodeling in smooth muscle cell tissue beds of transgenic mice.

Abstract

Research Article

Authors

J Wang, W Niu, Y Nikiforov, S Naito, S Chernausek, D Witte, D LeRoith, A Strauch, J A Fagin

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Myotonic dystrophy protein kinase is involved in the modulation of the Ca2+ homeostasis in skeletal muscle cells.
A A Benders, … , J H Veerkamp, B Wieringa
A A Benders, … , J H Veerkamp, B Wieringa
Published September 15, 1997
Citation Information: J Clin Invest. 1997;100(6):1440-1447. https://doi.org/10.1172/JCI119664.
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Myotonic dystrophy protein kinase is involved in the modulation of the Ca2+ homeostasis in skeletal muscle cells.

Abstract

Research Article

Authors

A A Benders, P J Groenen, F T Oerlemans, J H Veerkamp, B Wieringa

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Ventilation and oxygenation induce endothelial nitric oxide synthase gene expression in the lungs of fetal lambs.
S M Black, … , J Bristow, S J Soifer
S M Black, … , J Bristow, S J Soifer
Published September 15, 1997
Citation Information: J Clin Invest. 1997;100(6):1448-1458. https://doi.org/10.1172/JCI119665.
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Ventilation and oxygenation induce endothelial nitric oxide synthase gene expression in the lungs of fetal lambs.

Abstract

Research Article

Authors

S M Black, M J Johengen, Z D Ma, J Bristow, S J Soifer

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Removal of erythrocyte membrane iron in vivo ameliorates the pathobiology of murine thalassemia.
P V Browne, … , S L Schrier, R P Hebbel
P V Browne, … , S L Schrier, R P Hebbel
Published September 15, 1997
Citation Information: J Clin Invest. 1997;100(6):1459-1464. https://doi.org/10.1172/JCI119666.
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Removal of erythrocyte membrane iron in vivo ameliorates the pathobiology of murine thalassemia.

Abstract

Research Article

Authors

P V Browne, O Shalev, F A Kuypers, C Brugnara, A Solovey, N Mohandas, S L Schrier, R P Hebbel

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Modulation of the effector function of human macrophages for Histoplasma capsulatum by HIV-1. Role of the envelope glycoprotein gp120.
S Chaturvedi, S L Newman
S Chaturvedi, S L Newman
Published September 15, 1997
Citation Information: J Clin Invest. 1997;100(6):1465-1474. https://doi.org/10.1172/JCI119667.
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Histomorphometric assessment of the long-term effects of alendronate on bone quality and remodeling in patients with osteoporosis.
P M Chavassieux, … , A J Yates, P J Meunier
P M Chavassieux, … , A J Yates, P J Meunier
Published September 15, 1997
Citation Information: J Clin Invest. 1997;100(6):1475-1480. https://doi.org/10.1172/JCI119668.
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Histomorphometric assessment of the long-term effects of alendronate on bone quality and remodeling in patients with osteoporosis.

Abstract

Research Article

Authors

P M Chavassieux, M E Arlot, C Reda, L Wei, A J Yates, P J Meunier

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Binding of high molecular weight kininogen to human endothelial cells is mediated via a site within domains 2 and 3 of the urokinase receptor.
R W Colman, … , A Mazar, K R McCrae
R W Colman, … , A Mazar, K R McCrae
Published September 15, 1997
Citation Information: J Clin Invest. 1997;100(6):1481-1487. https://doi.org/10.1172/JCI119669.
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Binding of high molecular weight kininogen to human endothelial cells is mediated via a site within domains 2 and 3 of the urokinase receptor.

Abstract

Research Article

Authors

R W Colman, R A Pixley, S Najamunnisa, W Yan, J Wang, A Mazar, K R McCrae

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The beta2 subunit inhibits stimulation of the alpha1/beta1 form of soluble guanylyl cyclase by nitric oxide. Potential relevance to regulation of blood pressure.
G Gupta, … , L Yang, R S Danziger
G Gupta, … , L Yang, R S Danziger
Published September 15, 1997
Citation Information: J Clin Invest. 1997;100(6):1488-1492. https://doi.org/10.1172/JCI119670.
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Lipoprotein(a) vascular accumulation in mice. In vivo analysis of the role of lysine binding sites using recombinant adenovirus.
S D Hughes, … , R M Lawn, E M Rubin
S D Hughes, … , R M Lawn, E M Rubin
Published September 15, 1997
Citation Information: J Clin Invest. 1997;100(6):1493-1500. https://doi.org/10.1172/JCI119671.
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Lipoprotein(a) vascular accumulation in mice. In vivo analysis of the role of lysine binding sites using recombinant adenovirus.

Abstract

Research Article

Authors

S D Hughes, X J Lou, S Ighani, J Verstuyft, D J Grainger, R M Lawn, E M Rubin

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Overexpression of metallothionein in the heart of transgenic mice suppresses doxorubicin cardiotoxicity.
Y J Kang, … , M Voss-McCowan, P N Epstein
Y J Kang, … , M Voss-McCowan, P N Epstein
Published September 15, 1997
Citation Information: J Clin Invest. 1997;100(6):1501-1506. https://doi.org/10.1172/JCI119672.
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Overexpression of metallothionein in the heart of transgenic mice suppresses doxorubicin cardiotoxicity.

Abstract

Research Article

Authors

Y J Kang, Y Chen, A Yu, M Voss-McCowan, P N Epstein

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Tissue- and development-specific expression of multiple alternatively spliced transcripts of rat neuronal nitric oxide synthase.
M A Lee, … , Y A Lee, K Lindpaintner
M A Lee, … , Y A Lee, K Lindpaintner
Published September 15, 1997
Citation Information: J Clin Invest. 1997;100(6):1507-1512. https://doi.org/10.1172/JCI119673.
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Beta2-agonists prevent Th1 development by selective inhibition of interleukin 12.
P Panina-Bordignon, … , C Self, F Sinigaglia
P Panina-Bordignon, … , C Self, F Sinigaglia
Published September 15, 1997
Citation Information: J Clin Invest. 1997;100(6):1513-1519. https://doi.org/10.1172/JCI119674.
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Beta2-agonists prevent Th1 development by selective inhibition of interleukin 12.

Abstract

Research Article

Authors

P Panina-Bordignon, D Mazzeo, P D Lucia, D D'Ambrosio, R Lang, L Fabbri, C Self, F Sinigaglia

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Reduction of renal mass is lethal in mice lacking vimentin. Role of endothelin-nitric oxide imbalance.
F Terzi, … , P Briand, G Friedlander
F Terzi, … , P Briand, G Friedlander
Published September 15, 1997
Citation Information: J Clin Invest. 1997;100(6):1520-1528. https://doi.org/10.1172/JCI119675.
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Reduction of renal mass is lethal in mice lacking vimentin. Role of endothelin-nitric oxide imbalance.

Abstract

Research Article

Authors

F Terzi, D Henrion, E Colucci-Guyon, P Federici, C Babinet, B I Levy, P Briand, G Friedlander

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Comparison of DNA-lipid complexes and DNA alone for gene transfer to cystic fibrosis airway epithelia in vivo.
J Zabner, … , A E Smith, M J Welsh
J Zabner, … , A E Smith, M J Welsh
Published September 15, 1997
Citation Information: J Clin Invest. 1997;100(6):1529-1537. https://doi.org/10.1172/JCI119676.
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Comparison of DNA-lipid complexes and DNA alone for gene transfer to cystic fibrosis airway epithelia in vivo.

Abstract

Research Article

Authors

J Zabner, S H Cheng, D Meeker, J Launspach, R Balfour, M A Perricone, J E Morris, J Marshall, A Fasbender, A E Smith, M J Welsh

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Production and physiological actions of anandamide in the vasculature of the rat kidney.
D G Deutsch, … , G Stefano, L C Moore
D G Deutsch, … , G Stefano, L C Moore
Published September 15, 1997
Citation Information: J Clin Invest. 1997;100(6):1538-1546. https://doi.org/10.1172/JCI119677.
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Production and physiological actions of anandamide in the vasculature of the rat kidney.

Abstract

Research Article

Authors

D G Deutsch, M S Goligorsky, P C Schmid, R J Krebsbach, H H Schmid, S K Das, S K Dey, G Arreaza, C Thorup, G Stefano, L C Moore

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Reconstitution of mutant V2 vasopressin receptors by adenovirus-mediated gene transfer. Molecular basis and clinical implication.
T Schöneberg, … , T Gudermann, G Schultz
T Schöneberg, … , T Gudermann, G Schultz
Published September 15, 1997
Citation Information: J Clin Invest. 1997;100(6):1547-1556. https://doi.org/10.1172/JCI119678.
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Reconstitution of mutant V2 vasopressin receptors by adenovirus-mediated gene transfer. Molecular basis and clinical implication.

Abstract

Research Article

Authors

T Schöneberg, V Sandig, J Wess, T Gudermann, G Schultz

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Lipopolysaccharide-stimulated osteoclastogenesis is mediated by tumor necrosis factor via its P55 receptor.
Y Abu-Amer, … , J Edwards, S L Teitelbaum
Y Abu-Amer, … , J Edwards, S L Teitelbaum
Published September 15, 1997
Citation Information: J Clin Invest. 1997;100(6):1557-1565. https://doi.org/10.1172/JCI119679.
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Lipopolysaccharide-stimulated osteoclastogenesis is mediated by tumor necrosis factor via its P55 receptor.

Abstract

Research Article

Authors

Y Abu-Amer, F P Ross, J Edwards, S L Teitelbaum

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Biomechanical coupling in renin-releasing cells.
R M Carey, … , R A Gomez, P Q Barrett
R M Carey, … , R A Gomez, P Q Barrett
Published September 15, 1997
Citation Information: J Clin Invest. 1997;100(6):1566-1574. https://doi.org/10.1172/JCI119680.
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Biomechanical coupling in renin-releasing cells.

Abstract

Research Article

Authors

R M Carey, H E McGrath, E S Pentz, R A Gomez, P Q Barrett

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The effects of total lymphocyte deficiency on the extent of atherosclerosis in apolipoprotein E-/- mice.
A Daugherty, … , S E Roselaar, D J Rader
A Daugherty, … , S E Roselaar, D J Rader
Published September 15, 1997
Citation Information: J Clin Invest. 1997;100(6):1575-1580. https://doi.org/10.1172/JCI119681.
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The effects of total lymphocyte deficiency on the extent of atherosclerosis in apolipoprotein E-/- mice.

Abstract

Research Article

Authors

A Daugherty, E Puré, D Delfel-Butteiger, S Chen, J Leferovich, S E Roselaar, D J Rader

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Heterozygosity for a defective gene for CC chemokine receptor 5 is not the sole determinant for the immunologic and virologic phenotype of HIV-infected long-term nonprogressors.
O J Cohen, … , J B Margolick, A S Fauci
O J Cohen, … , J B Margolick, A S Fauci
Published September 15, 1997
Citation Information: J Clin Invest. 1997;100(6):1581-1589. https://doi.org/10.1172/JCI119682.
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Heterozygosity for a defective gene for CC chemokine receptor 5 is not the sole determinant for the immunologic and virologic phenotype of HIV-infected long-term nonprogressors.

Abstract

Research Article

Authors

O J Cohen, M Vaccarezza, G K Lam, B F Baird, K Wildt, P M Murphy, P A Zimmerman, T B Nutman, C H Fox, S Hoover, J Adelsberger, M Baseler, J Arthos, R T Davey Jr, R L Dewar, J Metcalf, D J Schwartzentruber, J M Orenstein, S Buchbinder, A J Saah, R Detels, J Phair, C Rinaldo, J B Margolick, A S Fauci

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Disruption of the guanylyl cyclase-C gene leads to a paradoxical phenotype of viable but heat-stable enterotoxin-resistant mice.
S Schulz, … , M Kuhn, D L Garbers
S Schulz, … , M Kuhn, D L Garbers
Published September 15, 1997
Citation Information: J Clin Invest. 1997;100(6):1590-1595. https://doi.org/10.1172/JCI119683.
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Glucose activates the carboxyl methylation of gamma subunits of trimeric GTP-binding proteins in pancreatic beta cells. Modulation in vivo by calcium, GTP, and pertussis toxin.
A Kowluru, … , G Li, S A Metz
A Kowluru, … , G Li, S A Metz
Published September 15, 1997
Citation Information: J Clin Invest. 1997;100(6):1596-1610. https://doi.org/10.1172/JCI119684.
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The syndecan family of proteoglycans. Novel receptors mediating internalization of atherogenic lipoproteins in vitro.
I V Fuki, … , E A Fisher, K J Williams
I V Fuki, … , E A Fisher, K J Williams
Published September 15, 1997
Citation Information: J Clin Invest. 1997;100(6):1611-1622. https://doi.org/10.1172/JCI119685.
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The syndecan family of proteoglycans. Novel receptors mediating internalization of atherogenic lipoproteins in vitro.

Abstract

Research Article

Authors

I V Fuki, K M Kuhn, I R Lomazov, V L Rothman, G P Tuszynski, R V Iozzo, T L Swenson, E A Fisher, K J Williams

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Novel autocrine feedback control of catecholamine release. A discrete chromogranin a fragment is a noncompetitive nicotinic cholinergic antagonist.
S K Mahata, … , B M Gill, R J Parmer
S K Mahata, … , B M Gill, R J Parmer
Published September 15, 1997
Citation Information: J Clin Invest. 1997;100(6):1623-1633. https://doi.org/10.1172/JCI119686.
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Novel autocrine feedback control of catecholamine release. A discrete chromogranin a fragment is a noncompetitive nicotinic cholinergic antagonist.

Abstract

Research Article

Authors

S K Mahata, D T O'Connor, M Mahata, S H Yoo, L Taupenot, H Wu, B M Gill, R J Parmer

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Congenital hyperthyroidism caused by a solitary toxic adenoma harboring a novel somatic mutation (serine281-->isoleucine) in the extracellular domain of the thyrotropin receptor.
P Kopp, … , J L Jameson, C Rodd
P Kopp, … , J L Jameson, C Rodd
Published September 15, 1997
Citation Information: J Clin Invest. 1997;100(6):1634-1639. https://doi.org/10.1172/JCI119687.
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Chloroquine induces human mononuclear phagocytes to inhibit and kill Cryptococcus neoformans by a mechanism independent of iron deprivation.
S M Levitz, … , A Tabuni, X Liu
S M Levitz, … , A Tabuni, X Liu
Published September 15, 1997
Citation Information: J Clin Invest. 1997;100(6):1640-1646. https://doi.org/10.1172/JCI119688.
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RGDN peptide interaction with endothelial alpha5beta1 integrin causes sustained endothelin-dependent vasoconstriction of rat skeletal muscle arterioles.
J E Mogford, … , G E Davis, G A Meininger
J E Mogford, … , G E Davis, G A Meininger
Published September 15, 1997
Citation Information: J Clin Invest. 1997;100(6):1647-1653. https://doi.org/10.1172/JCI119689.
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