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Article has an altmetric score of 6

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Referenced in 16 patents
30 readers on Mendeley
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Research Article Free access | 10.1172/JCI119633

Expression of mucosal homing receptor alpha4beta7 by circulating CD4+ cells with memory for intestinal rotavirus.

L S Rott, J R Rosé, D Bass, M B Williams, H B Greenberg, and E C Butcher

Department of Pathology and the Digestive Disease Center, Stanford University, Stanford, California 94305, USA. lrott@cmgm.stanford.edu

Find articles by Rott, L. in: PubMed | Google Scholar

Department of Pathology and the Digestive Disease Center, Stanford University, Stanford, California 94305, USA. lrott@cmgm.stanford.edu

Find articles by Rosé, J. in: PubMed | Google Scholar

Department of Pathology and the Digestive Disease Center, Stanford University, Stanford, California 94305, USA. lrott@cmgm.stanford.edu

Find articles by Bass, D. in: PubMed | Google Scholar

Department of Pathology and the Digestive Disease Center, Stanford University, Stanford, California 94305, USA. lrott@cmgm.stanford.edu

Find articles by Williams, M. in: PubMed | Google Scholar

Department of Pathology and the Digestive Disease Center, Stanford University, Stanford, California 94305, USA. lrott@cmgm.stanford.edu

Find articles by Greenberg, H. in: PubMed | Google Scholar

Department of Pathology and the Digestive Disease Center, Stanford University, Stanford, California 94305, USA. lrott@cmgm.stanford.edu

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Published September 1, 1997 - More info

Published in Volume 100, Issue 5 on September 1, 1997
J Clin Invest. 1997;100(5):1204–1208. https://doi.org/10.1172/JCI119633.
© 1997 The American Society for Clinical Investigation
Published September 1, 1997 - Version history
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Abstract

The integrin alpha4beta7 mediates lymphocyte binding to mucosal addressin cell adhesion molecule-1, and its expression defines lymphocytes capable of trafficking through the intestines and the intestinal lymphoid tissues. We examined the ability of discrete alpha4beta7(hi) and alpha4beta7- subsets of circulating memory phenotype (CD45RA-) CD4+ T cells to proliferate in response to rotavirus, a ubiquitous intestinal pathogen. alpha4beta7(hi) memory (CD45RA-) CD4+ T cells displayed much greater reactivity to rotavirus than alpha4beta7- memory or naive (CD45RA+) CD4+ T cells. In contrast, alpha4beta7- memory cells were the predominant population responsive to mumps antigen after intramuscular vaccination. Our results are consistent with the conclusion that natural rotavirus infection, an enteric pathogen, results in a specific circulating memory CD4+ response that is largely limited to the gut-homing alpha4beta7+ subpopulation. This phenotype is not shared with memory cells elicited by intramuscular immunization (shown here) or by skin contact allergens. The results support the hypothesis that gut trafficking memory CD4+ T cells comprise cellular memory for intestinal antigens and suggest that regulated expression of alpha4beta7 helps target and segregate intestinal versus systemic immune response.

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Referenced in 16 patents
30 readers on Mendeley
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