The causal chain between a gene and its effect on disease susceptibility cannot be understood until the effect has been localized in the DNA sequence. Recently, polymorphisms incorporated in the HapMap Project have made linkage disequilibrium (LD) the most powerful tool for localization. The genetics of LD, the maps and databases that it provides, and their use for association mapping, as well as alternative methods for gene localization, are briefly described.
Newton E. Morton
Title and authors | Publication | Year |
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Massachusetts General Hospital Comprehensive Clinical Psychiatry
JW Smoller, CT Finn, EE Gardner-Schuster |
Massachusetts General Hospital Comprehensive Clinical Psychiatry | 2008 |
Advances in the Research of Strategies and Methods for Analyzing Complex Traits
Z TANG, C XU |
Agricultural Sciences in China | 2008 |
Molecular Epidemiology: Applications in Cancer and Other Human Diseases
J Barnholtz-Sloan, I Halder, M Shriver |
Molecular Epidemiology: Applications in Cancer and Other Human Diseases | 2008 |
Sourcebook of Models for Biomedical Research
PM Conn |
2008 | |
The Domestic Cat, Felis catus, as a Model of Hereditary and Infectious Disease
Menotti-Raymond M, O\u2019Brien SJ |
2008 |