The causal chain between a gene and its effect on disease susceptibility cannot be understood until the effect has been localized in the DNA sequence. Recently, polymorphisms incorporated in the HapMap Project have made linkage disequilibrium (LD) the most powerful tool for localization. The genetics of LD, the maps and databases that it provides, and their use for association mapping, as well as alternative methods for gene localization, are briefly described.
Newton E. Morton
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Genome–Environment Associations, an Innovative Tool for Studying Heritable Evolutionary Adaptation in Orphan Crops and Wild Relatives
Cortés AJ, López-Hernández F, Blair MW |
Frontiers in Genetics | 2022 |
Genome-wide association study and identification of candidate genes for seed oil content in Brassica napus
L Pal, SK Sandhu, D Bhatia |
Euphytica | 2021 |
Oil Crop Genomics
H Tombuloglu, T Unver, G Tombuloglu, KR Hakeem |
2021 | |
High-Resolution Genetic Maps Identify Multiple Type 2 Diabetes Loci at Regulatory Hotspots in African Americans and Europeans
W Lau, T Andrew, N Maniatis |
The American Journal of Human Genetics | 2017 |
Genetic dissection of adventitious shoot regeneration in roses by employing genome-wide association studies
TH Nguyen, D Schulz, T Winkelmann, T Debener |
Plant Cell Reports | 2017 |
Genetic dissection of adventitious shoot regeneration in roses by employing genome-wide association studies.
Nguyen THN, Schulz D, Winkelmann T, Debener T |
Plant Cell Reports | 2017 |
The Decay of Disease Association with Declining Linkage Disequilibrium: A Fine Mapping Theorem
M Maadooliat, NK Bansal, J Upadhya, MR Farazi, X Li, MM He, SJ Hebbring, Z Ye, SJ Schrodi |
Frontiers in Genetics | 2016 |
Longevity Genes
G Atzmon |
2015 | |
Longevity Genes
G Atzmon |
2015 | |
Distribution and haplotype associations of XPD Lys751Gln, XRCC1 Arg280His and XRCC1 Arg399Gln polymorphisms with nasopharyngeal carcinoma in the Malaysian population
Shaneeta Visuvanathan, Pei-Pei Chong, Yoke-Yeow Yap, Chin-Chye Lim, Meng-Kuan Tan, Munn-Sann Lye |
Asian Pacific Journal of Cancer Prevention | 2014 |
Association mapping of quantitative trait loci for carcass and meat quality traits at the central part of chromosome 2 in Italian Large White pigs
S Čepica, P Zambonelli, F Weisz, M Bigi, A Knoll, Z Vykoukalová, M Masopust, M Gallo, L Buttazzoni, R Davoli |
Meat Science | 2013 |
Candidate Genes and Political Behavior
E Charney, W English |
American Political Science Review | 2012 |
Optimizing Experimental Design in Genetics
B McClosky, SD Tanksley |
Journal of Optimization Theory and Applications | 2012 |
Encyclopedia of Life Sciences
B Dahlbäck |
Encyclopedia of Life Sciences | 2011 |
Molecular Diagnostics
A Athanassiadou, EF Stavrou, A Papachatzopoulou, GP Patrinos |
Molecular Diagnostics | 2010 |
Bioinformatics for Systems Biology
S Krawetz |
2009 | |
Analytical Approaches and Population Types for Finding and Utilizing QTL in Complex Plant Populations
CH Sneller, DE Mather, S Crepieux |
Crop Science | 2009 |
Massachusetts General Hospital Comprehensive Clinical Psychiatry
JW Smoller, CT Finn, EE Gardner-Schuster |
Massachusetts General Hospital Comprehensive Clinical Psychiatry | 2008 |
Advances in the Research of Strategies and Methods for Analyzing Complex Traits
Z TANG, C XU |
Agricultural Sciences in China | 2008 |
Molecular Epidemiology: Applications in Cancer and Other Human Diseases
J Barnholtz-Sloan, I Halder, M Shriver |
Molecular Epidemiology: Applications in Cancer and Other Human Diseases | 2008 |
Sourcebook of Models for Biomedical Research
PM Conn |
2008 | |
The Domestic Cat, Felis catus, as a Model of Hereditary and Infectious Disease
Menotti-Raymond M, O\u2019Brien SJ |
2008 | |
Genotype matrix mapping: searching for quantitative trait loci interactions in genetic variation in complex traits
S Isobe, A Nakaya, S Tabata |
DNA research : an international journal for rapid publication of reports on genes and genomes | 2007 |
Magnetic resonance imaging as a tool for in vivo and ex vivo anatomical phenotyping in experimental genetic models
A Pitiot, Z Pausova, M Prior, J Perrin, N Loyse, T Paus |
Human Brain Mapping | 2007 |
Association Between Human Polymorphic DNA Markers and Hypoxia Adaptation in Sherpa Detected by a Preliminary Genome Scan
S Malacrida, Y Katsuyama, Y Droma, B Basnyat, C Angelini, M Ota, GA Danieli |
Annals of Human Genetics | 2007 |
Genetic Variability of Major Inflammatory Mediators Has No Impact on the Outcome of Kidney Transplantation
I Brabcova, J Petrasek, P Hribova, K Hyklova, K Bartosova, J Lacha, O Viklický |
Transplantation | 2007 |
A novel method to express SNP-based genetic heterogeneity,Ψ, and its use to measure linkage disequilibrium for multiple SNPs,Dg, and to estimate absolute maximum of haplotype frequency
R Yamada, F Matsuda |
Genetic Epidemiology | 2007 |
Diagnosis of neuronal ceroid lipofuscinosis: mutation detection strategies
AL Getty, PG Rothberg, DA Pearce |
Expert Opinion on Medical Diagnostics | 2007 |
snp.plotter: an R-based SNP/haplotype association and linkage disequilibrium plotting package
A Luna, KK Nicodemus |
Bioinformatics | 2007 |
Mechanisms of disease: genetics of rheumatoid arthritis--ethnic differences in disease-associated genes
R Yamada, K Yamamoto |
Nature Clinical Practice Rheumatology | 2007 |
Magnetic resonance imaging as a tool for in vivo and ex vivo anatomical phenotyping in experimental genetic models.
Pitiot A, Pausova Z, Prior M, Perrin J, Loyse N, Paus T |
Human Brain Mapping | 2007 |
Microarray technology in obstetrics and gynecology: A guide for clinicians
K Ward |
American Journal of Obstetrics and Gynecology | 2006 |
Host susceptibility to persistent hepatitis B virus infection
YL He, YR Zhao, SL Zhang, SM Lin |
World journal of gastroenterology : WJG | 2006 |
Fine-Scale Map of Encyclopedia of DNA Elements Regions in the Korean Population
YK Yoo, X Ke, S Hong, HY Jang, K Park, S Kim, TJ Ahn, YD Lee, O Song, NY Rho, MS Lee, YS Lee, J Kim, YJ Kim, JM Yang, K Song, K Kimm, B Weir, LR Cardon, JE Lee, JJ Hwang |
Genetics | 2006 |
Mapping the new frontier: complex genetic disorders
R Mayeux |
Journal of Clinical Investigation | 2005 |