The causal chain between a gene and its effect on disease susceptibility cannot be understood until the effect has been localized in the DNA sequence. Recently, polymorphisms incorporated in the HapMap Project have made linkage disequilibrium (LD) the most powerful tool for localization. The genetics of LD, the maps and databases that it provides, and their use for association mapping, as well as alternative methods for gene localization, are briefly described.
Newton E. Morton
Title and authors | Publication | Year |
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Genotype matrix mapping: searching for quantitative trait loci interactions in genetic variation in complex traits
S Isobe, A Nakaya, S Tabata |
DNA research : an international journal for rapid publication of reports on genes and genomes | 2007 |
Magnetic resonance imaging as a tool for in vivo and ex vivo anatomical phenotyping in experimental genetic models
A Pitiot, Z Pausova, M Prior, J Perrin, N Loyse, T Paus |
Human Brain Mapping | 2007 |
Association Between Human Polymorphic DNA Markers and Hypoxia Adaptation in Sherpa Detected by a Preliminary Genome Scan
S Malacrida, Y Katsuyama, Y Droma, B Basnyat, C Angelini, M Ota, GA Danieli |
Annals of Human Genetics | 2007 |
Genetic Variability of Major Inflammatory Mediators Has No Impact on the Outcome of Kidney Transplantation
I Brabcova, J Petrasek, P Hribova, K Hyklova, K Bartosova, J Lacha, O Viklický |
Transplantation | 2007 |
A novel method to express SNP-based genetic heterogeneity,Ψ, and its use to measure linkage disequilibrium for multiple SNPs,Dg, and to estimate absolute maximum of haplotype frequency
R Yamada, F Matsuda |
Genetic Epidemiology | 2007 |
Diagnosis of neuronal ceroid lipofuscinosis: mutation detection strategies
AL Getty, PG Rothberg, DA Pearce |
Expert Opinion on Medical Diagnostics | 2007 |
snp.plotter: an R-based SNP/haplotype association and linkage disequilibrium plotting package
A Luna, KK Nicodemus |
Bioinformatics | 2007 |
Mechanisms of disease: genetics of rheumatoid arthritis--ethnic differences in disease-associated genes
R Yamada, K Yamamoto |
Nature Clinical Practice Rheumatology | 2007 |
Magnetic resonance imaging as a tool for in vivo and ex vivo anatomical phenotyping in experimental genetic models.
Pitiot A, Pausova Z, Prior M, Perrin J, Loyse N, Paus T |
Human Brain Mapping | 2007 |