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Abstract
In the human genome, the majority of protein-encoding genes are interrupted by introns, which are removed from primary transcripts by a macromolecular enzyme known as the spliceosome. Spliceosomes can constitutively remove all the introns in a primary transcript to yield a fully spliced mRNA or alternatively splice primary transcripts leading to the production of many different mRNAs from one gene. This review examines how spliceosomes can recombine two primary transcripts in trans to reprogram messenger RNAs.
Authors
Mariano A. Garcia-Blanco
Total citations by year
Citation information
Citations to this article in year 2017 (3)
| Title and authors | Publication | Year |
|---|---|---|
|
Optimization of trans-Splicing for Huntington's Disease RNA Therapy
H Rindt, CM Tom, CL Lorson, VB Mattis |
Frontiers in neuroscience | 2017 |
|
De novo assembly and characterization of breast cancer transcriptomes identifies large numbers of novel fusion-gene transcripts of potential functional significance
VK Mittal, JF McDonald |
BMC Medical Genomics | 2017 |
|
Alternative Splicing in Aging and Age-related Diseases
H Li, Z Wang, T Ma, G Wei, T Ni |
Translational Medicine of Aging | 2017 |
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ISSN: 0021-9738 (print), 1558-8238 (online)