In the human genome, the majority of protein-encoding genes are interrupted by introns, which are removed from primary transcripts by a macromolecular enzyme known as the spliceosome. Spliceosomes can constitutively remove all the introns in a primary transcript to yield a fully spliced mRNA or alternatively splice primary transcripts leading to the production of many different mRNAs from one gene. This review examines how spliceosomes can recombine two primary transcripts in trans to reprogram messenger RNAs.
Mariano A. Garcia-Blanco
Title and authors | Publication | Year |
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Expression analysis and functional activity of interleukin-7 splice variants
NK Vudattu, I Magalhaes, H Hoehn, D Pan, MJ Maeurer |
Genes and Immunity | 2008 |
Sequestering of the 3′ Splice Site in a Theophylline-Responsive Riboswitch Allows Ligand-Dependent Control of Alternative Splicing
V Gusti, DS Kim, RK Gaur |
Oligonucleotides | 2008 |
Trans-splicing into highly abundant albumin transcripts for production of therapeutic proteins in vivo
J Wang, SG Mansfield, CA Cote, PD Jiang, K Weng, MJ Amar, BH Brewer, AT Remaley, GJ McGarrity, MA Garcia-Blanco, M Puttaraju |
Molecular Therapy | 2008 |
Development of a single vector system that enhances trans-splicing of SMN2 transcripts
TH Coady, TD Baughan, M Shababi, MA Passini, CL Lorson |
PloS one | 2008 |
Development of a Single Vector System that Enhances Trans-Splicing of SMN2 Transcripts
TH Coady, TD Baughan, M Shababi, MA Passini, CL Lorson, J Valcarcel |
PloS one | 2008 |