In the human genome, the majority of protein-encoding genes are interrupted by introns, which are removed from primary transcripts by a macromolecular enzyme known as the spliceosome. Spliceosomes can constitutively remove all the introns in a primary transcript to yield a fully spliced mRNA or alternatively splice primary transcripts leading to the production of many different mRNAs from one gene. This review examines how spliceosomes can recombine two primary transcripts in trans to reprogram messenger RNAs.
Mariano A. Garcia-Blanco
Title and authors | Publication | Year |
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Correction of tau mis-splicing caused by FTDP-17 MAPT mutations by spliceosome-mediated RNA trans-splicing
T Rodriguez-Martin, K Anthony, MA Garcia-Blanco, SG Mansfield, BH Anderton, JM Gallo |
Human Molecular Genetics | 2009 |
Splicing therapeutics in SMN2 and APOB
B Khoo, AR Krainer |
Current opinion in molecular therapeutics | 2009 |
Detection of human interchromosomal trans-splicing in sequence databanks
RH Herai, ME Yamagishi |
Briefings in Bioinformatics | 2009 |
161st ENMC International Workshop on nemaline myopathy and related disorders, Newcastle upon Tyne, 2008
NG Laing, C Wallgren-Pettersson |
Neuromuscular Disorders | 2009 |