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Abstract
In the human genome, the majority of protein-encoding genes are interrupted by introns, which are removed from primary transcripts by a macromolecular enzyme known as the spliceosome. Spliceosomes can constitutively remove all the introns in a primary transcript to yield a fully spliced mRNA or alternatively splice primary transcripts leading to the production of many different mRNAs from one gene. This review examines how spliceosomes can recombine two primary transcripts in trans to reprogram messenger RNAs.
Authors
Mariano A. Garcia-Blanco
Total citations by year
Citation information
Citations to this article in year 2010 (6)
| Title and authors | Publication | Year |
|---|---|---|
|
RNA reprogramming and repair based on trans-splicing group I ribozymes
T Fiskaa, ÅB Birgisdottir |
New Biotechnology | 2010 |
|
Exon exchange approach to repair Duchenne dystrophin transcripts
S Lorain, C Peccate, ML Hir, L Garcia |
PloS one | 2010 |
|
Trans-splicing-mediated improvement in a severe mouse model of spinal muscular atrophy
TH Coady, CL Lorson |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2010 |
|
Exon Exchange Approach to Repair Duchenne Dystrophin Transcripts
S Lorain, C Peccate, ML Hir, L Garcia, A Lewin |
PloS one | 2010 |
|
ARCHAEA-ExPRESs targeting of α-tubulin 4 mRNA: a model for high-specificity trans-splicing
G Deidda, N Rossi, S Putti, GP Tocchini-Valentini |
The FASEB Journal | 2010 |
|
Molecular Pathology of Liver Diseases
SP Monga |
2010 |
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