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Abstract
In the human genome, the majority of protein-encoding genes are interrupted by introns, which are removed from primary transcripts by a macromolecular enzyme known as the spliceosome. Spliceosomes can constitutively remove all the introns in a primary transcript to yield a fully spliced mRNA or alternatively splice primary transcripts leading to the production of many different mRNAs from one gene. This review examines how spliceosomes can recombine two primary transcripts in trans to reprogram messenger RNAs.
Authors
Mariano A. Garcia-Blanco
Total citations by year
Citation information
Citations to this article in year 2006 (4)
| Title and authors | Publication | Year |
|---|---|---|
|
Complementary intron sequence motifs associated with human exon repetition: a role for intragenic, inter-transcript interactions in gene expression
RJ Dixon, IC Eperon, NJ Samani |
Bioinformatics | 2006 |
|
Stimulating Full-Length SMN2 Expression by Delivering Bifunctional RNAs via a Viral Vector
T Baughan, M Shababi, TH Coady, AM Dickson, GE Tullis, CL Lorson |
Molecular Therapy | 2006 |
|
RNA interference: a potential therapeutic tool for silencing splice isoforms linked to human diseases
RK Gaur |
BioTechniques | 2006 |
|
Alternative Splicing and Disease
P Jeanteur |
2006 |
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