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Citations to this article

Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression.
A De Vos, … , D Pipeleers, F Schuit
A De Vos, … , D Pipeleers, F Schuit
Published November 1, 1995
Citation Information: J Clin Invest. 1995;96(5):2489-2495. https://doi.org/10.1172/JCI118308.
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Research Article Article has an altmetric score of 7

Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression.

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Abstract

Glucose homeostasis is controlled by a glucose sensor in pancreatic beta-cells. Studies on rodent beta-cells have suggested a role for GLUT2 and glucokinase in this control function and in mechanisms leading to diabetes. Little direct evidence exists so far to implicate these two proteins in glucose recognition by human beta-cells. The present in vitro study investigates the role of glucose transport and phosphorylation in beta-cell preparations from nondiabetic human pancreata. Human beta-cells differ from rodent beta-cells in glucose transporter gene expression (predominantly GLUT1 instead of GLUT2), explaining their low Km (3 mmol/liter) and low VMAX (3 mmol/min per liter) for 3-O-methyl glucose transport. The 100-fold lower GLUT2 abundance in human versus rat beta-cells is associated with a 10-fold slower uptake of alloxan, explaining their resistance to this rodent diabetogenic agent. Human and rat beta-cells exhibit comparable glucokinase expression with similar flux-generating influence on total glucose utilization. These data underline the importance of glucokinase but not of GLUT2 in the glucose sensor of human beta-cells.

Authors

A De Vos, H Heimberg, E Quartier, P Huypens, L Bouwens, D Pipeleers, F Schuit

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 Total
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Citations to this article in year 2020 (11)

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Modeling different types of diabetes using human pluripotent stem cells
EM Abdelalim
Cellular and Molecular Life Sciences 2020
From Genetic Association to Molecular Mechanisms for Islet-cell Dysfunction in Type 2 Diabetes
KK Mattis, AL Gloyn
Journal of Molecular Biology 2020
Fanconi–Bickel Syndrome: A Review of the Mechanisms That Lead to Dysglycaemia
S Sharari, M Abou-Alloul, K Hussain, FA Khan
International journal of molecular sciences 2020
Glucose transporters in pancreatic islets
C Berger, D Zdzieblo
Pflügers Archiv - European Journal of Physiology 2020
Augmented mitochondrial energy metabolism is an early response to chronic glucose stress in human pancreatic beta cells
I Chareyron, S Christen, S Moco, A Valsesia, S Lassueur, L Dayon, CB Wollheim, JS Domingo, A Wiederkehr
Diabetologia 2020
A CRISPR/Cas9 genome editing pipeline in the EndoC-βH1 cell line to study genes implicated in beta cell function
Grotz AK, Abaitua F, Navarro-Guerrero E, Hastoy B, Ebner D, Gloyn AL
Wellcome Open Research 2020
Sodium–glucose cotransporters: Functional properties and pharmaceutical potential
R Sano, Y Shinozaki, T Ohta
Journal of Diabetes Investigation 2020
Indomethacin decreases insulin secretion by reducing KCa3.1 as a biomarker of pancreatic tumor and causes apoptotic cell death
AK Kacar
Journal of Biochemical and Molecular Toxicology 2020
A new perspective of probe development for imaging pancreatic beta cell in vivo
CW Neo, LM Ciaramicoli, AA Soetedjo, AK Teo, NY Kang
Seminars in Cell & Developmental Biology 2020
Early postnatal stress impairs insulin secretion in response to psychological stress in adult rats
H Zardooz, F Sadeghimahalli, F Khodagholi
Journal of Endocrinological Investigation 2020
Derivation of a human induced pluripotent stem cell line (QBRIi007-A) from a patient carrying a homozygous intronic mutation (c.613-7T>G) in the SLC2A2 gene
AK Elsayed, M Aghadi, S Al-Khawaga, K Hussain, EM Abdelalim
Stem Cell Research 2020

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