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Citations to this article

Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression.
A De Vos, … , D Pipeleers, F Schuit
A De Vos, … , D Pipeleers, F Schuit
Published November 1, 1995
Citation Information: J Clin Invest. 1995;96(5):2489-2495. https://doi.org/10.1172/JCI118308.
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Research Article Article has an altmetric score of 7

Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression.

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Abstract

Glucose homeostasis is controlled by a glucose sensor in pancreatic beta-cells. Studies on rodent beta-cells have suggested a role for GLUT2 and glucokinase in this control function and in mechanisms leading to diabetes. Little direct evidence exists so far to implicate these two proteins in glucose recognition by human beta-cells. The present in vitro study investigates the role of glucose transport and phosphorylation in beta-cell preparations from nondiabetic human pancreata. Human beta-cells differ from rodent beta-cells in glucose transporter gene expression (predominantly GLUT1 instead of GLUT2), explaining their low Km (3 mmol/liter) and low VMAX (3 mmol/min per liter) for 3-O-methyl glucose transport. The 100-fold lower GLUT2 abundance in human versus rat beta-cells is associated with a 10-fold slower uptake of alloxan, explaining their resistance to this rodent diabetogenic agent. Human and rat beta-cells exhibit comparable glucokinase expression with similar flux-generating influence on total glucose utilization. These data underline the importance of glucokinase but not of GLUT2 in the glucose sensor of human beta-cells.

Authors

A De Vos, H Heimberg, E Quartier, P Huypens, L Bouwens, D Pipeleers, F Schuit

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 Total
Citations: 2 9 8 10 16 11 12 7 9 16 18 19 13 20 14 39 5 5 4 5 6 4 5 3 5 4 8 3 9 4 293
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Citations to this article in year 2014 (19)

Title and authors Publication Year
Impaired Islet Function in Commonly Used Transgenic Mouse Lines due to Human Growth Hormone Minigene Expression
B Brouwers, G de Faudeur, AB Osipovich, L Goyvaerts, K Lemaire, L Boesmans, EJ Cauwelier, M Granvik, VP Pruniau, L Van Lommel, J Van Schoors, JS Stancill, I Smolders, V Goffin, N Binart, P in’t Veld, J Declercq, MA Magnuson, JW Creemers, F Schuit, A Schraenen
Cell Metabolism 2014
Human  -Cell Proliferation and Intracellular Signaling Part 2: Still Driving in the Dark Without a Road Map
E Bernal-Mizrachi, RN Kulkarni, DK Scott, F Mauvais-Jarvis, AF Stewart, A Garcia-Ocana
Diabetes 2014
Analysis of transcription factors key for mouse pancreatic development establishes NKX2-2 and MNX1 mutations as causes of neonatal diabetes in man
SE Flanagan, ED Franco, HL Allen, M Zerah, MM Abdul-Rasoul, JA Edge, H Stewart, E Alamiri, K Hussain, S Wallis, L Vries, O Rubio-Cabezas, JA Houghton, EL Edghill, AM Patch, S Ellard, AT Hattersley
Cell Metabolism 2014
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GG Holz, CA Leech, OG Chepurny
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2014
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E Graaf-Roelfsema
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Glucose regulation of glucagon secretion
E Gylfe, P Gilon
Diabetes Research and Clinical Practice 2014
Cellular Endocrinology in Health and Disease
AA Bremer, WL Miller
Cellular Endocrinology in Health and Disease 2014
Effect of early life stress on pancreatic isolated islets’ insulin secretion in young adult male rats subjected to chronic stress
F Sadeghimahalli, R Karbaschi, H Zardooz, F Khodagholi, F Rostamkhani
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Potential role of skeletal muscle glucose metabolism on the regulation of insulin secretion: Organ crosstalk and insulin secretion
ML Mizgier, M Casas, A Contreras-Ferrat, P Llanos, JE Galgani
Obesity Reviews 2014
Nutrient regulation of insulin secretion and action
P Newsholme, V Cruzat, F Arfuso, K Keane
Journal of Endocrinology 2014
Transcriptomic analysis of the lesser spotted catshark (Scyliorhinus canicula) pancreas, liver and brain reveals molecular level conservation of vertebrate pancreas function
JF Mulley, AD Hargreaves, MJ Hegarty, RS Heller, MT Swain
BMC Genomics 2014
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The Journal of biological chemistry 2014
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B Thorens
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Calcium signaling in pancreatic β-cells in health and in Type 2 diabetes
P Gilon, HY Chae, GA Rutter, MA Ravier
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Reference Module in Biomedical Sciences
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2014
Islets of Langerhans, 2. ed
MS Islam
Islets of Langerhans, 2. ed. 2014
Impaired Islet Function in Commonly Used Transgenic Mouse Lines due to Human Growth Hormone Minigene Expression
B Brouwers, G de Faudeur, AB Osipovich, L Goyvaerts, K Lemaire, L Boesmans, EJ Cauwelier, M Granvik, VP Pruniau, L Van Lommel, J Van Schoors, JS Stancill, I Smolders, V Goffin, N Binart, P int Veld, J Declercq, MA Magnuson, JW Creemers, F Schuit, A Schraenen
Cell Metabolism 2014
Islets of Langerhans
S Islam
2014

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