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Citations to this article

Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression.
A De Vos, … , D Pipeleers, F Schuit
A De Vos, … , D Pipeleers, F Schuit
Published November 1, 1995
Citation Information: J Clin Invest. 1995;96(5):2489-2495. https://doi.org/10.1172/JCI118308.
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Research Article Article has an altmetric score of 7

Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression.

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Abstract

Glucose homeostasis is controlled by a glucose sensor in pancreatic beta-cells. Studies on rodent beta-cells have suggested a role for GLUT2 and glucokinase in this control function and in mechanisms leading to diabetes. Little direct evidence exists so far to implicate these two proteins in glucose recognition by human beta-cells. The present in vitro study investigates the role of glucose transport and phosphorylation in beta-cell preparations from nondiabetic human pancreata. Human beta-cells differ from rodent beta-cells in glucose transporter gene expression (predominantly GLUT1 instead of GLUT2), explaining their low Km (3 mmol/liter) and low VMAX (3 mmol/min per liter) for 3-O-methyl glucose transport. The 100-fold lower GLUT2 abundance in human versus rat beta-cells is associated with a 10-fold slower uptake of alloxan, explaining their resistance to this rodent diabetogenic agent. Human and rat beta-cells exhibit comparable glucokinase expression with similar flux-generating influence on total glucose utilization. These data underline the importance of glucokinase but not of GLUT2 in the glucose sensor of human beta-cells.

Authors

A De Vos, H Heimberg, E Quartier, P Huypens, L Bouwens, D Pipeleers, F Schuit

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 Total
Citations: 2 9 8 10 16 11 12 7 9 16 18 19 13 20 14 39 5 5 4 5 6 4 5 3 5 4 8 3 9 4 293
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Citations to this article in year 2016 (16)

Title and authors Publication Year
Urea impairs β-cell glycolysis and insulin secretion in chronic kidney disease
Laetitia Koppe, Elsa Nyam, Kevin Vivot, Jocelyn Manning Fox, Xiao-Qing Dai, Bich Nguyen, Dominique Trudel, Attané Camille, Valentine Moullé, Patrick MacDonald, Julien Ghislain, Vincent Poitout
Journal of Clinical Investigation 2016
Monogenic Diabetes: What It Teaches Us on the Common Forms of Type 1 and Type 2 Diabetes
Y Yang, L Chan
Endocrine reviews 2016
Disallowed and Allowed Gene Expression: Two Faces of Mature Islet Beta Cells
K Lemaire, L Thorrez, F Schuit
Annual Review of Nutrition 2016
Insulin-positive, Glut2-low cells present within mouse pancreas exhibit lineage plasticity and are enriched within extra-islet endocrine cell clusters
CA Beamish, BJ Strutt, EJ Arany, DJ Hill
Islets 2016
β-Cell dysfunction in diabetes: a crisis of identity?
MF Brereton, M Rohm, FM Ashcroft
Diabetes Obesity and Metabolism 2016
Genome-edited human stem cell-derived beta cells: a powerful tool for drilling down on type 2 diabetes GWAS biology
NL Beer, AL Gloyn
F1000Research 2016
Mass production of functional human pancreatic β-cells: why and how?
R Scharfmann, M Didiesheim, P Richards, V Chandra, M Oshima, O Albagli
Diabetes Obesity and Metabolism 2016
Glucose control of glucagon secretion—‘There’s a brand-new gimmick every year’
E Gylfe
Upsala Journal of Medical Sciences 2016
Activation of GPR119 Stimulates Human β -Cell Replication and Neogenesis in Humanized Mice with Functional Human Islets
Ansarullah, C Free, J Christopherson, Q Chen, J Gao, C Liu, A Naji, A Rabinovitch, Z Guo
Journal of Diabetes Research 2016
Glucose transporters: physiological and pathological roles
AM Navale, AN Paranjape
Biophysical Reviews 2016
Serotonin competence of mouse beta cells during pregnancy
L Goyvaerts, A Schraenen, F Schuit
Diabetologia 2016
Molecular Nutrition and Diabetes
D Sala, A Zorzano
Molecular Nutrition and Diabetes 2016
Drug Discovery Toxicology: From Target Assessment to Translational Biomarkers
JK Chuah, YN Lam, P Huang, D Zink
Drug Discovery Toxicology: From Target Assessment to Translational Biomarkers 2016
Glycogen metabolism in the glucose-sensing and supply-driven β-cell
LE Andersson, LM Nicholas, K Filipsson, J Sun, A Medina, M Al-Majdoub, M Fex, H Mulder, P Spégel
FEBS Letters 2016
The Pancreatic β-Cell: A Bioenergetic Perspective
DG Nicholls
Physiological reviews 2016
Circadian Clocks: Role in Health and Disease
ML Gumz
2016

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