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Citations to this article

Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression.
A De Vos, … , D Pipeleers, F Schuit
A De Vos, … , D Pipeleers, F Schuit
Published November 1, 1995
Citation Information: J Clin Invest. 1995;96(5):2489-2495. https://doi.org/10.1172/JCI118308.
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Research Article Article has an altmetric score of 7

Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression.

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Abstract

Glucose homeostasis is controlled by a glucose sensor in pancreatic beta-cells. Studies on rodent beta-cells have suggested a role for GLUT2 and glucokinase in this control function and in mechanisms leading to diabetes. Little direct evidence exists so far to implicate these two proteins in glucose recognition by human beta-cells. The present in vitro study investigates the role of glucose transport and phosphorylation in beta-cell preparations from nondiabetic human pancreata. Human beta-cells differ from rodent beta-cells in glucose transporter gene expression (predominantly GLUT1 instead of GLUT2), explaining their low Km (3 mmol/liter) and low VMAX (3 mmol/min per liter) for 3-O-methyl glucose transport. The 100-fold lower GLUT2 abundance in human versus rat beta-cells is associated with a 10-fold slower uptake of alloxan, explaining their resistance to this rodent diabetogenic agent. Human and rat beta-cells exhibit comparable glucokinase expression with similar flux-generating influence on total glucose utilization. These data underline the importance of glucokinase but not of GLUT2 in the glucose sensor of human beta-cells.

Authors

A De Vos, H Heimberg, E Quartier, P Huypens, L Bouwens, D Pipeleers, F Schuit

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 Total
Citations: 2 9 8 10 16 11 12 7 9 16 18 19 13 20 14 39 5 5 4 5 6 4 5 3 5 4 8 3 9 4 293
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Citations to this article in year 2012 (20)

Title and authors Publication Year
Congenital Hyperinsulinism Caused by Hexokinase I Expression or Glucokinase-Activating Mutation in a Subset of  -Cells
JC Henquin, C Sempoux, J Marchandise, S Godecharles, Y Guiot, M Nenquin, J Rahier
Diabetes 2012
Involvement of heparan sulfate 3-O-sulfotransferase isoform-1 in the insulin secretion pathway
I Takahashi, K Ohashi, K Nata
Journal of Diabetes Investigation 2012
Diabetes Mellitus and the β Cell: The Last Ten Years
FM Ashcroft, P Rorsman
Cell 2012
The SLC2 (GLUT) family of membrane transporters
M Mueckler, B Thorens
Molecular Aspects of Medicine 2012
High-fat diet consumption during pregnancy and the early post-natal period leads to decreased α cell plasticity in the nonhuman primate
SM Comstock, LD Pound, JM Bishop, DL Takahashi, AM Kostrba, MS Smith, KL Grove
Molecular Metabolism 2012
Cholesterol‐enriched membrane rafts and insulin secretion
R Dirkx, M Solimena
Journal of Diabetes Investigation 2012
The pancreatic beta cell surface proteome
I Stützer, D Esterházy, M Stoffel
Diabetologia 2012
Regeneration of pancreatic beta-cell mass for the treatment of diabetes
J Domínguez-Bendala, L Inverardi, C Ricordi
Expert Opinion on Biological Therapy 2012
SLC2A2 mutations can cause neonatal diabetes, suggesting GLUT2 may have a role in human insulin secretion
FH Sansbury, SE Flanagan, JA Houghton, FL Shen, AM Al-Senani, AM Habeb, M Abdullah, A Kariminejad, S Ellard, AT Hattersley
Diabetologia 2012
GLP-1 receptor activated insulin secretion from pancreatic β-cells: mechanism and glucose dependence
AR Meloni, MB DeYoung, C Lowe, DG Parkes
Diabetes, Obesity and Metabolism 2012
A tale of two glucose transporters: how GLUT2 re-emerged as a contender for glucose transport into the human beta cell
M Bunt, AL Gloyn
Diabetologia 2012
Restoring insulin production for type 1 diabetes: Restoring insulin for diabetes
E Tudurí, JE Bruin, TJ Kieffer
Journal of Diabetes 2012
Metabolite profiling reveals normal metabolic control in carriers of mutations in the glucokinase gene (MODY2)
P Spégel, E Ekholm, T Tuomi, L Groop, H Mulder, K Filipsson
Diabetes 2012
Zinc transporters and their role in the pancreatic β‐cell
K Lemaire, F Chimienti, F Schuit
Journal of Diabetes Investigation 2012
Computational Modeling of Glucose Transport in Pancreatic β-Cells Identifies Metabolic Thresholds and Therapeutic Targets in Diabetes
C Luni, JD Marth, FJ Doyle, F Castiglione
PloS one 2012
Overcoming the spatial barriers of the stimulus secretion cascade in pancreatic β-cells
PR Huypens, M Huang, JW Joseph
Islets 2012
 -Cell-Specific Gene Repression: A Mechanism to Protect Against Inappropriate or Maladjusted Insulin Secretion?
F Schuit, LV Lommel, M Granvik, L Goyvaerts, G Faudeur, A Schraenen, K Lemaire
Diabetes 2012
SSTR2 is the functionally dominant somatostatin receptor in human pancreatic β- and α-cells
B Kailey, M de Bunt, S Cheley, PR Johnson, PE MacDonald, AL Gloyn, P Rorsman, M Braun
American journal of physiology. Endocrinology and metabolism 2012
Human Insulin Secreted from Insulinogenic Xenograft Restores Normoglycemia in Type 1 Diabetic Mice without Immunosuppression
J Kim, S Park, HM Kang, CW Ahn, HC Kwon, JH Song, YJ Lee, KH Lee, H Yang, SY Baek, SH Yoo, SH Kim, H Kim
Cell Transplantation 2012
A tale of two glucose transporters: how GLUT2 re-emerged as a contender for glucose transport into the human beta cell
M van de Bunt, AL Gloyn
Diabetologia 2012

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