Glucose homeostasis is controlled by a glucose sensor in pancreatic beta-cells. Studies on rodent beta-cells have suggested a role for GLUT2 and glucokinase in this control function and in mechanisms leading to diabetes. Little direct evidence exists so far to implicate these two proteins in glucose recognition by human beta-cells. The present in vitro study investigates the role of glucose transport and phosphorylation in beta-cell preparations from nondiabetic human pancreata. Human beta-cells differ from rodent beta-cells in glucose transporter gene expression (predominantly GLUT1 instead of GLUT2), explaining their low Km (3 mmol/liter) and low VMAX (3 mmol/min per liter) for 3-O-methyl glucose transport. The 100-fold lower GLUT2 abundance in human versus rat beta-cells is associated with a 10-fold slower uptake of alloxan, explaining their resistance to this rodent diabetogenic agent. Human and rat beta-cells exhibit comparable glucokinase expression with similar flux-generating influence on total glucose utilization. These data underline the importance of glucokinase but not of GLUT2 in the glucose sensor of human beta-cells.
A De Vos, H Heimberg, E Quartier, P Huypens, L Bouwens, D Pipeleers, F Schuit
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Calcium signaling in pancreatic β-cells in health and in Type 2 diabetes
P Gilon, HY Chae, GA Rutter, MA Ravier |
Cell Calcium | 2014 |
Reference Module in Biomedical Sciences
DL Sackett, RB Haynes |
2014 | |
Islets of Langerhans, 2. ed
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Impaired Islet Function in Commonly Used Transgenic Mouse Lines due to Human Growth Hormone Minigene Expression
B Brouwers, G de Faudeur, AB Osipovich, L Goyvaerts, K Lemaire, L Boesmans, EJ Cauwelier, M Granvik, VP Pruniau, L Van Lommel, J Van Schoors, JS Stancill, I Smolders, V Goffin, N Binart, P int Veld, J Declercq, MA Magnuson, JW Creemers, F Schuit, A Schraenen |
Cell Metabolism | 2014 |
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S Islam |
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Nervous control of postnatal beta-cell proliferation and glucose homeostasis
David Tarussio, Salima Metref, Pascal Seyer, Lourdes Mounien, David Vallois, Christophe Magnan, Marc Foretz, Bernard Thorens |
Journal of Clinical Investigation | 2013 |
Islet β cell mass in diabetes and how it relates to function, birth, and death
GC Weir, S Bonner-Weir |
Annals of the New York Academy of Sciences | 2013 |
Maturation and function of human embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant into mice
JE Bruin, A Rezania, J Xu, K Narayan, JK Fox, JJ O’Neil, TJ Kieffer |
Diabetologia | 2013 |
Sympathetic Innervation during Development Is Necessary for Pancreatic Islet Architecture and Functional Maturation
P Borden, J Houtz, SD Leach, R Kuruvilla |
Cell Reports | 2013 |
Glucose principally regulates insulin secretion in mouse islets by controlling the numbers of granule fusion events per cell
JT Low, JM Mitchell, OH Do, J Bax, A Rawlings, M Zavortink, G Morgan, RG Parton, HY Gaisano, P Thorn |
Diabetologia | 2013 |
Characterization of polyhormonal insulin-producing cells derived in vitro from human embryonic stem cells
JE Bruin, S Erener, J Vela, X Hu, JD Johnson, HT Kurata, FC Lynn, JM Piret, A Asadi, A Rezania, TJ Kieffer |
Stem Cell Research | 2013 |
Enrichment of human embryonic stem cell-derived NKX6.1-expressing pancreatic progenitor cells accelerates the maturation of insulin-secreting cells in vivo
A Rezania, JE Bruin, J Xu, K Narayan, JK Fox, JJ O'Neil, TJ Kieffer |
Stem Cells | 2013 |
Regulation of Insulin Secretion in Human Pancreatic Islets
P Rorsman, M Braun |
Annual Review of Physiology | 2013 |
N-glycosylation modulates the membrane sub-domain distribution and activity of glucose transporter 2 in pancreatic beta cells
K Ohtsubo, S Takamatsu, C Gao, H Korekane, TM Kurosawa, N Taniguchi |
Biochemical and Biophysical Research Communications | 2013 |
Metabolic Signaling in Fuel-Induced Insulin Secretion
M Prentki, FM Matschinsky, SR Madiraju |
Cell Metabolism | 2013 |
Parp1 deficient mice are protected from streptozotocin-induced diabetes but not caerulein-induced pancreatitis, independent of the induction of Reg family genes
B Li, C Luo, S Chowdhury, ZH Gao, JL Liu |
Regulatory Peptides | 2013 |
Glucose-stimulated insulin secretion: the hierarchy of its multiple cellular and subcellular mechanisms
P Meda, F Schuit |
Diabetologia | 2013 |
Influence of melatonin receptor signalling on parameters involved in blood glucose regulation
I Bazwinsky-Wutschke, L Bieseke, E Mühlbauer, E Peschke |
Journal of Pineal Research | 2013 |
Congenital Hyperinsulinism Caused by Hexokinase I Expression or Glucokinase-Activating Mutation in a Subset of -Cells
JC Henquin, C Sempoux, J Marchandise, S Godecharles, Y Guiot, M Nenquin, J Rahier |
Diabetes | 2012 |
Involvement of heparan sulfate 3-O-sulfotransferase isoform-1 in the insulin secretion pathway
I Takahashi, K Ohashi, K Nata |
Journal of Diabetes Investigation | 2012 |
Diabetes Mellitus and the β Cell: The Last Ten Years
FM Ashcroft, P Rorsman |
Cell | 2012 |
The SLC2 (GLUT) family of membrane transporters
M Mueckler, B Thorens |
Molecular Aspects of Medicine | 2012 |
High-fat diet consumption during pregnancy and the early post-natal period leads to decreased α cell plasticity in the nonhuman primate
SM Comstock, LD Pound, JM Bishop, DL Takahashi, AM Kostrba, MS Smith, KL Grove |
Molecular Metabolism | 2012 |
Cholesterol‐enriched membrane rafts and insulin secretion
R Dirkx, M Solimena |
Journal of Diabetes Investigation | 2012 |
The pancreatic beta cell surface proteome
I Stützer, D Esterházy, M Stoffel |
Diabetologia | 2012 |
Regeneration of pancreatic beta-cell mass for the treatment of diabetes
J Domínguez-Bendala, L Inverardi, C Ricordi |
Expert Opinion on Biological Therapy | 2012 |
SLC2A2 mutations can cause neonatal diabetes, suggesting GLUT2 may have a role in human insulin secretion
FH Sansbury, SE Flanagan, JA Houghton, FL Shen, AM Al-Senani, AM Habeb, M Abdullah, A Kariminejad, S Ellard, AT Hattersley |
Diabetologia | 2012 |
GLP-1 receptor activated insulin secretion from pancreatic β-cells: mechanism and glucose dependence
AR Meloni, MB DeYoung, C Lowe, DG Parkes |
Diabetes, Obesity and Metabolism | 2012 |
A tale of two glucose transporters: how GLUT2 re-emerged as a contender for glucose transport into the human beta cell
M Bunt, AL Gloyn |
Diabetologia | 2012 |
Restoring insulin production for type 1 diabetes: Restoring insulin for diabetes
E Tudurí, JE Bruin, TJ Kieffer |
Journal of Diabetes | 2012 |
Metabolite profiling reveals normal metabolic control in carriers of mutations in the glucokinase gene (MODY2)
P Spégel, E Ekholm, T Tuomi, L Groop, H Mulder, K Filipsson |
Diabetes | 2012 |
Zinc transporters and their role in the pancreatic β‐cell
K Lemaire, F Chimienti, F Schuit |
Journal of Diabetes Investigation | 2012 |
Computational Modeling of Glucose Transport in Pancreatic β-Cells Identifies Metabolic Thresholds and Therapeutic Targets in Diabetes
C Luni, JD Marth, FJ Doyle, F Castiglione |
PloS one | 2012 |
Overcoming the spatial barriers of the stimulus secretion cascade in pancreatic β-cells
PR Huypens, M Huang, JW Joseph |
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-Cell-Specific Gene Repression: A Mechanism to Protect Against Inappropriate or Maladjusted Insulin Secretion?
F Schuit, LV Lommel, M Granvik, L Goyvaerts, G Faudeur, A Schraenen, K Lemaire |
Diabetes | 2012 |
SSTR2 is the functionally dominant somatostatin receptor in human pancreatic β- and α-cells
B Kailey, M de Bunt, S Cheley, PR Johnson, PE MacDonald, AL Gloyn, P Rorsman, M Braun |
American journal of physiology. Endocrinology and metabolism | 2012 |
Human Insulin Secreted from Insulinogenic Xenograft Restores Normoglycemia in Type 1 Diabetic Mice without Immunosuppression
J Kim, S Park, HM Kang, CW Ahn, HC Kwon, JH Song, YJ Lee, KH Lee, H Yang, SY Baek, SH Yoo, SH Kim, H Kim |
Cell Transplantation | 2012 |
A tale of two glucose transporters: how GLUT2 re-emerged as a contender for glucose transport into the human beta cell
M van de Bunt, AL Gloyn |
Diabetologia | 2012 |
A genetically-engineered human pancreatic beta cell line with glucose-inducible insulin secretion
Philippe Ravassard, Yasmine Hazhouz, Severine Pechberty, Emilie Bricou-Neveu, Mathieu Armanet, Paul Czernichow, Raphaël Scharfmann |
Journal of Clinical Investigation | 2011 |
Islet-enriched gene expression and glucose-induced insulin secretion in human and mouse islets
C Dai, M Brissova, Y Hang, C Thompson, G Poffenberger, A Shostak, Z Chen, R Stein, AC Powers |
Diabetologia | 2011 |
Pathway to diabetes through attenuation of pancreatic beta cell glycosylation and glucose transport
K Ohtsubo, MZ Chen, JM Olefsky, JD Marth |
Nature Medicine | 2011 |
Oxidative Stress and Disease
I Paur, M Carlsen, B Halvorsen, R Blomhoff |
Herbal Medicine | 2011 |
Mapping of INS promoter interactions reveals its role in long-range regulation of SYT8 transcription
Z Xu, G Wei, I Chepelev, K Zhao, G Felsenfeld |
Nature Structural & Molecular Biology | 2011 |
New type 2 diabetes risk genes provide new insights in insulin secretion mechanisms
SA Schäfer, F Machicao, A Fritsche, HU Häring, K Kantartzis |
Diabetes Research and Clinical Practice | 2011 |
GLUT2 (SLC2A2) is not the principal glucose transporter in human pancreatic beta cells: Implications for understanding genetic association signals at this locus
LJ McCulloch, M de Bunt, M Braun, KN Frayn, A Clark, AL Gloyn |
Molecular Genetics and Metabolism | 2011 |
Persistent glucose transporter expression on pancreatic beta cells from longstanding type 1 diabetic individuals
KT Coppieters, A Wiberg, N Amirian, TW Kay, MG von Herrath |
Diabetes/Metabolism Research and Reviews | 2011 |
The functional and molecular characterisation of human embryonic stem cell-derived insulin-positive cells compared with adult pancreatic beta cells
CL Basford, KJ Prentice, AB Hardy, F Sarangi, SJ Micallef, X Li, Q Guo, AG Elefanty, EG Stanley, G Keller, EM Allister, MC Nostro, MB Wheeler |
Diabetologia | 2011 |
Ultrastructural analysis, zinc transporters, glucose transporters and hormones expression in new world primate (Callithrix jacchus) and human pancreatic islets
D Mohanasundaram, C Drogemuller, J Brealey, CF Jessup, C Milner, C Murgia, CJ Lang, A Milton, PD Zalewski, GR Russ, PT Coates |
General and Comparative Endocrinology | 2011 |
The central role of calcium in the effects of cytokines on beta-cell function: implications for type 1 and type 2 diabetes
JW Ramadan, SR Steiner, CM O'Neill, CS Nunemaker |
Cell Calcium | 2011 |
Pancreatic islet-specific overexpression of Reg3β protein induced the expression of pro-islet genes and protected the mice against streptozotocin-induced diabetes mellitus
X Xiong, X Wang, B Li, S Chowdhury, Y Lu, CB Srikant, G Ning, JL Liu |
American journal of physiology. Endocrinology and metabolism | 2011 |
Differences between Human and Rodent Pancreatic Islets: LOW PYRUVATE CARBOXYLASE, ATP CITRATE LYASE, AND PYRUVATE CARBOXYLATION AND HIGH GLUCOSE-STIMULATED ACETOACETATE IN HUMAN PANCREATIC ISLETS
MJ MacDonald, MJ Longacre, SW Stoker, M Kendrick, A Thonpho, LJ Brown, NM Hasan, S Jitrapakdee, T Fukao, MS Hanson, LA Fernandez, J Odorico |
The Journal of biological chemistry | 2011 |
Atlas of Diabetes
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Transient Receptor Potential Channels | 2010 |
Transient Receptor Potential Channels
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Transient Receptor Potential Channels
S Islam |
Transient Receptor Potential Channels | 2010 |
Transient Receptor Potential Channels
S Islam |
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Transient Receptor Potential Channels
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Transient Receptor Potential Channels
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Transient Receptor Potential Channels | 2010 |
Transient Receptor Potential Channels
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Transient Receptor Potential Channels | 2010 |
Transient Receptor Potential Channels
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Transient Receptor Potential Channels | 2010 |
Transient Receptor Potential Channels
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Transient Receptor Potential Channels | 2010 |
Transient Receptor Potential Channels
S Islam |
Transient Receptor Potential Channels | 2010 |
Transient Receptor Potential Channels
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Transient Receptor Potential Channels | 2010 |
Transient Receptor Potential Channels
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Transient Receptor Potential Channels
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Transient Receptor Potential Channels | 2010 |
Transient Receptor Potential Channels
S Islam |
Transient Receptor Potential Channels | 2010 |
Transient Receptor Potential Channels
S Islam |
Transient Receptor Potential Channels | 2010 |
Transient Receptor Potential Channels
S Islam |
Transient Receptor Potential Channels | 2010 |
Transient Receptor Potential Channels
S Islam |
Transient Receptor Potential Channels | 2010 |
Transient Receptor Potential Channels
S Islam |
Transient Receptor Potential Channels | 2010 |
Transient Receptor Potential Channels
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Transient Receptor Potential Channels | 2010 |
Transient Receptor Potential Channels
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Transient Receptor Potential Channels | 2010 |
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The Journal of biological chemistry | 2010 |
Glucose stimulates human beta cell replication in vivo in islets transplanted into NOD–severe combined immunodeficiency (SCID) mice
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Diabetologia | 2010 |
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Diabetes | 2010 |
The role of peroxisome proliferator-activated receptor γ in pancreatic β cell function and survival: therapeutic implications for the treatment of type 2 diabetes mellitus
D Gupta, T Kono, C Evans-Molina |
Diabetes, Obesity and Metabolism | 2010 |
Textbook of Diabetes
PM Jones, SJ Persaud |
Textbook of Diabetes | 2010 |
The protein family of glucose transport facilitators: It's not only about glucose after all
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Brain Glucose Transporter Protein 2 and Sporadic Alzheimer's Disease
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Translational Neuroscience | 2010 |
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General and Comparative Endocrinology | 2010 |
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Calcineurin Signaling Regulates Human Islet β-Cell Survival
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The Journal of biological chemistry | 2010 |
Gene Expression Profiles of Beta-Cell Enriched Tissue Obtained by Laser Capture Microdissection from Subjects with Type 2 Diabetes
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PloS one | 2010 |
Effects of the HIV Protease Inhibitor Ritonavir on GLUT4 Knock-out Mice
AK Vyas, JC Koster, A Tzekov, PW Hruz |
The Journal of biological chemistry | 2010 |
Protein Markers for Insulin-Producing Beta Cells with Higher Glucose Sensitivity
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PloS one | 2010 |
Glucose Suppression of Glucagon Secretion: METABOLIC AND CALCIUM RESPONSES FROM α-CELLS IN INTACT MOUSE PANCREATIC ISLETS
SJ le Marchand, DW Piston |
The Journal of biological chemistry | 2010 |
BetaSys: Systems Biology of Regulated Exocytosis in Pancreatic ß-Cells
B Booß-Bavnbek, B Klösgen, J Larsen, F Pociot, E Renström |
2010 | |
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Structure, Function, and Regulation of Insulin-Degrading Enzyme
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Vitamins and hormones | 2009 |
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Nature Reviews Endocrinology | 2009 |
The glucose transporter 2 undergoes plasma membrane endocytosis and lysosomal degradation in a secretagogue-dependent manner
JC Hou, D Williams, J Vicogne, JE Pessin |
Endocrinology | 2009 |
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A Leturque, E Brot-Laroche, ML Gall |
American journal of physiology. Endocrinology and metabolism | 2009 |
Stem Cell Therapy for Diabetes
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Beta cells within single human islets originate from multiple progenitors
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PloS one | 2008 |
Voltage-Gated Ion Channels in Human Pancreatic -Cells: Electrophysiological Characterization and Role in Insulin Secretion
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Diabetes | 2008 |
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Diabetologia | 2008 |
Cx36 makes channels coupling human pancreatic -cells, and correlates with insulin expression
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Human Molecular Genetics | 2008 |
Beta Cells within Single Human Islets Originate from Multiple Progenitors
R Scharfmann, X Xiao, H Heimberg, J Mallet, P Ravassard, T Chan-Ling |
PloS one | 2008 |
Mechanisms and Outcomes of Drug- and Toxicant-Induced Liver Toxicity in Diabetes
T Wang, K Shankar, MJ Ronis, HM Mehendale |
Critical Reviews in Toxicology | 2007 |
Mechanisms of action of glucagon-like peptide 1 in the pancreas
ME Doyle, JM Egan |
Pharmacology & Therapeutics | 2007 |
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K Docherty, AS Bernardo, L Vallier |
Seminars in Cell & Developmental Biology | 2007 |
Low levels of glucose transporters and % MathType!Translator!2!1!AMS LaTeX.tdl!TeX -- AMS-LaTeX! % MathType!MTEF!2!1!+- % feaaeaart1ev0aaatCvAUfeBSjuyZL2yd9gzLbvyNv2CaerbbjxAHX % garmWu51MyVXgatuuDJXwAK1uy0HwmaeHbfv3ySLgzG0uy0Hgip5wz % aebbnrfifHhDYfgasaacH8qrps0lbbf9q8WrFfeuY-Hhbbf9v8qqaq % Fr0xc9pk0xbba9q8WqFfea0-yr0RYxir-Jbba9q8aq0-yq-He9q8qq % Q8frFve9Fve9Ff0dmeaabaqaciGacaGaaeqabaWaaeWaeaaakeaaca % WGlbWaa0baaSqaaiaadgeacaWGubGaamiuaaqaaiabgUcaRaaaaaa!3BE3! $$ K^{ + }_{{ATP}} $$ channels in human pancreatic beta cells early in development
CC Richardson, K Hussain, PM Jones, S Persaud, K Löbner, A Boehm, A Clark, MR Christie |
Diabetologia | 2007 |
Paradoxical stimulation of glucagon secretion by high glucose concentrations
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B Desvergne, L Michalik, W Wahli |
Physiological reviews | 2006 |
Nutrient Control of Insulin Secretion in Isolated Normal Human Islets
JC Henquin, D Dufrane, M Nenquin |
Diabetes | 2006 |
Differential subcellular distribution of glucose transporters GLUT1–6 and GLUT9 in human cancer: Ultrastructural localization of GLUT1 and GLUT5 in breast tumor tissues
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Journal of Cellular Physiology | 2006 |
Things we have learned from tilapia islet xenotransplantation
EL Alexander, KC Dooley, B Pohajdak, BY Xu, JR Wright |
General and Comparative Endocrinology | 2006 |
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PE MacDonald, JW Joseph, P Rorsman |
Philosophical Transactions of the Royal Society B: Biological Sciences | 2005 |
The role of GLUT2 in dietary sugar handling
A Leturque, E Brot-Laroche, M Gall, E Stolarczyk, V Tobin |
Journal of Physiology and Biochemistry | 2005 |
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SD Guerra, L Marselli, R Lupi, U Boggi, F Mosca, L Benzi, SD Prato, P Marchetti |
Journal of Diabetes and its Complications | 2005 |
Loss of ARNT/HIF1β Mediates Altered Gene Expression and Pancreatic-Islet Dysfunction in Human Type 2 Diabetes
JE Gunton, RN Kulkarni, SH Yim, T Okada, WJ Hawthorne, YH Tseng, RS Roberson, C Ricordi, PJ O’Connell, FJ Gonzalez, CR Kahn |
Cell | 2005 |
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A Leturque, E Brot-Laroche, ML Gall, E Stolarczyk, V Tobin |
Journal of Physiology and Biochemistry | 2005 |
Developmental biology of the pancreas
PL Merino |
Cell Biochemistry and Biophysics | 2004 |
Tilapia islet grafts are highly alloxan-resistant
BY Xu, CM Morrison, H Yang, JR Wright |
General and Comparative Endocrinology | 2004 |
Hyperinsulinism in Infancy: From Basic Science to Clinical Disease
MJ Dunne, KE Cosgrove, RM Shepherd, A Aynsley-Green, KJ Lindley |
Physiological reviews | 2004 |
Establishment and Application of in Vitro Membrane Potential Assays in Cell Lines with Endogenous or Recombinant Expression of ATP-Sensitive Potassium Channels (Kir6.2/SUR1) Using a Fluorescent Probe Kit
P Arkhammar, P Wahl, B Gerlach, T Fremming, JB Hansen |
Journal of biomolecular screening | 2004 |
HIV protease inhibitors acutely impair glucose-stimulated insulin release
JC Koster, MS Remedi, H Qiu, CG Nichols, PW Hruz |
Diabetes | 2003 |
International Textbook of Diabetes Mellitus
RA DeFronzo, L Mandarino, E Ferrannini |
International Textbook of Diabetes Mellitus | 2003 |
Broad expression of fructose-1,6-bisphosphatase and phosphoenolpyruvate carboxykinase provide evidence for gluconeogenesis in human tissues other than liver and kidney: EXPRESSION OF FBPase AND PEPCK IN ADULT HUMAN TISSUES
AJ Yánez, F Nualart, C Droppelmann, R Bertinat, M Brito, II Concha, JC Slebe |
Journal of Cellular Physiology | 2003 |
Membrane Transporter Diseases
S Bröer, CA Wagner |
2003 | |
Mechanism underlying resistance of human pancreatic beta cells against toxicity of streptozotocin and alloxan
M Elsner, M Tiedge, S Lenzen |
Diabetologia | 2003 |
Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3
Y Heremans, MV de Casteele, P Veld, G Gradwohl, P Serup, O Madsen, D Pipeleers, H Heimberg |
The Journal of Cell Biology | 2002 |
Glucokinase Is the Likely Mediator of Glucosensing in Both Glucose-Excited and Glucose-Inhibited Central Neurons
AA Dunn-Meynell, VH Routh, L Kang, L Gaspers, BE Levin |
Diabetes | 2002 |
Human β Cells Are Exceedingly Resistant to Streptozotocin in Vivo
H Yang, JR Wright |
Endocrinology | 2002 |
Differential sensitivity of GLUT1- and GLUT2-expressing beta cells to streptozotocin
M Hosokawa, W Dolci, B Thorens |
Biochemical and Biophysical Research Communications | 2001 |
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M Hosokawa, W Dolci, B Thorens |
Biochemical and Biophysical Research Communications | 2001 |
Glucose Sensing in Pancreatic -Cells: A Model for the Study of Other Glucose-Regulated Cells in Gut, Pancreas, and Hypothalamus
FC Schuit, P Huypens, H Heimberg, DG Pipeleers |
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Molecular Basis of Pancreas Development and Function
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Characterization and partial purification of liver glucose transporter GLUT2
M Lachaal, AL Rampal, J Ryu, W Lee, JS Hah, CY Jung |
Biochimica et Biophysica Acta (BBA) - Biomembranes | 2000 |
Subcellular localization of aldolase B
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Journal of Cellular Biochemistry | 2000 |
The Role of Glucose and Its Metabolism in the Regulation of Glucokinase Expression in Isolated Human Pancreatic Islets
R Gasa, ME Fabregat, R Gomis |
Biochemical and Biophysical Research Communications | 2000 |
Transgenic Reexpression of GLUT1 or GLUT2 in Pancreatic β Cells Rescues GLUT2-null Mice from Early Death and Restores Normal Glucose-stimulated Insulin Secretion
B Thorens, MT Guillam, F Beermann, R Burcelin, M Jaquet |
The Journal of biological chemistry | 2000 |
Human Islets in Mixed Islet Grafts Protect Mouse Pancreatic β-Cells from Alloxan Toxicity
B Tyrberg, DL Eizirik, SL Marklund, B Olejnicka, OD Madsen, A Andersson |
Pharmacology & Toxicology | 1999 |
Human islets of Langerhans express theδC isoform of calcium/calmodulin-dependent protein kinase II
L Southam, R Ashfield, R Cox, M Lathrop, SJ Ashcroft |
Diabetes/Metabolism Research and Reviews | 1999 |
Expression of the hexose transporters GLUT1 and GLUT2 during the early development of the human brain
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Brain Research | 1999 |
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Biochemical Journal | 1999 |
Cellular origin of hexokinase in pancreatic islets
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The Journal of biological chemistry | 1999 |
Streptozotocin Dose–Response Curve in Tilapia, a Glucose-Responsive Teleost Fish
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General and Comparative Endocrinology | 1999 |
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American journal of physiology. Endocrinology and metabolism | 1999 |
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Molecular and Cellular Biochemistry | 1999 |
Les transporteurs d'hexoses chez l'homme: leur rôle dans l'insulinosensibilité des tissus périphériques
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La Revue de Médecine Interne | 1998 |
D-Glucose Combined Chronic Toxicity and Carcinogenicity Studdjs in Sprague-Dawley Rats and Syrian Golden Hamsters
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Drug and Chemical Toxicology | 1998 |
Aspects of Novel Sites of Regulation of the Insulin Stimulus-Secretion Coupling in Normal and Diabetic Pancreatic Islets
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Nature Genetics | 1997 |
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Human Islets of Langerhans Express Multiple Isoforms of Calcium/Calmodulin-Dependent Protein Kinase II
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Biochemical and Biophysical Research Communications | 1997 |
Metabolic Fate of Glucose in Purified Islet Cells: GLUCOSE-REGULATED ANAPLEROSIS IN β CELLS
F Schuit, AD Vos, S Farfari, K Moens, D Pipeleers, T Brun, M Prentki |
The Journal of biological chemistry | 1997 |
Role of the GLUT 2 Glucose Transporter in the Response of the L-type Pyruvate Kinase Gene to Glucose in Liver-derived Cells
B Antoine, AM Lefrançois-Martinez, GL Guillou, A Leturque, A Vandewalle, A Kahn |
The Journal of biological chemistry | 1997 |
Clinical Research in Diabetes and Obesity
B Draznin, R Rizza |
1997 | |
Expression of Glucokinase in Glucose-Unresponsive Human Fetal Pancreatic Islet-Like Cell Clusters1
J Tu, BE Tuch |
The Journal of clinical endocrinology and metabolism | 1997 |
Glucose-Stimulated Genes and Prospects of Gene Therapy for Type I Diabetes*
D Mitanchez, B Doiron, R Chen, A Kahn |
Endocrine reviews | 1997 |
Prolonged exposure of human beta cells to elevated glucose levels results in sustained cellular activation leading to a loss of glucose regulation
Z Ling, DG Pipeleers |
Journal of Clinical Investigation | 1996 |
Localization of the fructose 1,6-bisphosphatase at the nuclear periphery
DE Sáez, CD Figueroa, II Concha, JC Slebe |
Journal of Cellular Biochemistry | 1996 |
The glucose sensor protein glucokinase is expressed in glucagon-producing alpha-cells
H Heimberg, AD Vos, K Moens, E Quartier, L Bouwens, D Pipeleers, EV Schaftingen, O Madsen, F Schuit |
Proceedings of the National Academy of Sciences | 1996 |
EJB Reviews 1996
P Christen, E Hofmann |
1996 |