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Citations to this article

Reperfusion injury induces apoptosis in rabbit cardiomyocytes.
R A Gottlieb, … , B M Babior, R L Engler
R A Gottlieb, … , B M Babior, R L Engler
Published October 1, 1994
Citation Information: J Clin Invest. 1994;94(4):1621-1628. https://doi.org/10.1172/JCI117504.
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Research Article Article has an altmetric score of 6

Reperfusion injury induces apoptosis in rabbit cardiomyocytes.

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Abstract

The most effective way to limit myocardial ischemic necrosis is reperfusion, but reperfusion itself may result in tissue injury, which has been difficult to separate from ischemic injury. This report identifies elements of apoptosis (programmed cell death) in myocytes as a response to reperfusion but not ischemia. The hallmark of apoptosis, nucleosomal ladders of DNA fragments (approximately 200 base pairs), was detected in ischemic/reperfused rabbit myocardial tissue but not in normal or ischemic-only rabbit hearts. Granulocytopenia did not prevent nucleosomal DNA cleavage. In situ nick end labeling demonstrated DNA fragmentation predominantly in myocytes. The pattern of nuclear chromatin condensation was distinctly different in reperfused than in persistently ischemic tissue by transmission electron microscopy. Apoptosis may be a specific feature of reperfusion injury in cardiac myocytes, leading to late cell death.

Authors

R A Gottlieb, K O Burleson, R A Kloner, B M Babior, R L Engler

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1988 1981 1977 Total
Citations: 4 2 10 12 13 12 23 19 25 33 24 28 33 37 37 34 41 30 42 37 48 50 67 45 65 66 63 52 53 31 16 2 1 1 1 1057
Citation information
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Citations to this article in year 2005 (48)

Title and authors Publication Year
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European Heart Journal 2005
Apoptosis and oncosis in acute coronary syndromes: Assessment and implications
BI Jugdutt, HA Idikio
Molecular and Cellular Biochemistry 2005
Biochemical dysfunction in heart mitochondria exposed to ischaemia and reperfusion
G Solaini, DA Harris
Biochemical Journal 2005
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M Hase, C Depre, SF Vatner, J Sadoshima
Biochemical Journal 2005
Gene transfer of the pancaspase inhibitor P35 reduces myocardial infarct size and improves cardiac function
L Bott-Flügel, HJ Weig, M Knödler, C Städele, A Moretti, KL Laugwitz, M Seyfarth
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Death begets failure in the heart
RS Foo, K Mani, RN Kitsis
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F Fiordaliso, S Chimenti, L Staszewsky, A Bai, E Carlo, I Cuccovillo, M Doni, M Mengozzi, R Tonelli, P Ghezzi, T Coleman, M Brines, A Cerami, R Latini
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Clinical and Experimental Pharmacology and Physiology 2005
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Pulmonary Apoptosis After Supraceliac Aorta Clamping in a Rat Model1
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