The most effective way to limit myocardial ischemic necrosis is reperfusion, but reperfusion itself may result in tissue injury, which has been difficult to separate from ischemic injury. This report identifies elements of apoptosis (programmed cell death) in myocytes as a response to reperfusion but not ischemia. The hallmark of apoptosis, nucleosomal ladders of DNA fragments (approximately 200 base pairs), was detected in ischemic/reperfused rabbit myocardial tissue but not in normal or ischemic-only rabbit hearts. Granulocytopenia did not prevent nucleosomal DNA cleavage. In situ nick end labeling demonstrated DNA fragmentation predominantly in myocytes. The pattern of nuclear chromatin condensation was distinctly different in reperfused than in persistently ischemic tissue by transmission electron microscopy. Apoptosis may be a specific feature of reperfusion injury in cardiac myocytes, leading to late cell death.
R A Gottlieb, K O Burleson, R A Kloner, B M Babior, R L Engler
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Title and authors | Publication | Year |
---|---|---|
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B Wu, R Lin, R Dai, C Chen, H Wu, M Hong |
European Journal of Pharmacology | 2013 |
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International Journal of Cardiology | 2013 |
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F Chen, Y Cao, H Qi, L Li, W Huang, Y Wang, H Sun |
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D Lee, S Bae, Q Ke, J Lee, B Song, SA Karumanchi, G Khang, HS Choi, PM Kang |
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C Suo, L Sun, S Yang |
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H2O2-responsive molecularly engineered polymer nanoparticles as ischemia/reperfusion-targeted nanotherapeutic agents
D Lee, S Bae, D Hong, H Lim, JH Yoon, O Hwang, S Park, Q Ke, G Khang, PM Kang |
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Soluble TNF Receptors Are Associated with Infarct Size and Ventricular Dysfunction in ST-Elevation Myocardial Infarction
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Dynasore Protects Mitochondria and Improves Cardiac Lusitropy in Langendorff Perfused Mouse Heart
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Prognostic Value of TNF-Related Apoptosis Inducing Ligand (TRAIL) in Acute Coronary Syndrome Patients
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Cardiac Remodeling
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