Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Reperfusion injury induces apoptosis in rabbit cardiomyocytes.
R A Gottlieb, … , B M Babior, R L Engler
R A Gottlieb, … , B M Babior, R L Engler
Published October 1, 1994
Citation Information: J Clin Invest. 1994;94(4):1621-1628. https://doi.org/10.1172/JCI117504.
View: Text | PDF
Research Article Article has an altmetric score of 6

Reperfusion injury induces apoptosis in rabbit cardiomyocytes.

  • Text
  • PDF
Abstract

The most effective way to limit myocardial ischemic necrosis is reperfusion, but reperfusion itself may result in tissue injury, which has been difficult to separate from ischemic injury. This report identifies elements of apoptosis (programmed cell death) in myocytes as a response to reperfusion but not ischemia. The hallmark of apoptosis, nucleosomal ladders of DNA fragments (approximately 200 base pairs), was detected in ischemic/reperfused rabbit myocardial tissue but not in normal or ischemic-only rabbit hearts. Granulocytopenia did not prevent nucleosomal DNA cleavage. In situ nick end labeling demonstrated DNA fragmentation predominantly in myocytes. The pattern of nuclear chromatin condensation was distinctly different in reperfused than in persistently ischemic tissue by transmission electron microscopy. Apoptosis may be a specific feature of reperfusion injury in cardiac myocytes, leading to late cell death.

Authors

R A Gottlieb, K O Burleson, R A Kloner, B M Babior, R L Engler

×

Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1988 1981 1977 Total
Citations: 3 2 10 12 13 12 23 19 25 33 24 28 33 37 37 34 41 30 42 37 48 50 67 45 65 66 63 52 53 31 16 2 1 1 1 1056
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2013 (33)

Title and authors Publication Year
Fluorescence tomography of rapamycin-induced autophagy and cardioprotection in vivo
HH Chen, C Mekkaoui, H Cho, S Ngoy, B Marinelli, P Waterman, M Nahrendorf, R Liao, L Josephson, DE Sosnovik
Circulation. Cardiovascular imaging 2013
Cell death in the myocardium: my heart won't go on
AM Orogo, ÅB Gustafsson
IUBMB Life (International Union of Biochemistry and Molecular Biology: Life) 2013
Apoptosis repressor with a CARD domain (ARC) restrains Bax-mediated pathogenesis in dystrophic skeletal muscle
J Davis, JQ Kwong, RN Kitsis, JD Molkentin
PloS one 2013
Endocrine protection of ischemic myocardium by FGF21 from the liver and adipose tissue
SQ Liu, D Roberts, A Kharitonenkov, B Zhang, SM Hanson, YC Li, LQ Zhang, YH Wu
Scientific Reports 2013
Soluble TNF receptors are associated with infarct size and ventricular dysfunction in ST-elevation myocardial infarction
L Nilsson, A Szymanowski, E Swahn, L Jonasson
PloS one 2013
Dynasore protects mitochondria and improves cardiac lusitropy in Langendorff perfused mouse heart
D Gao, L Zhang, R Dhillon, TT Hong, RM Shaw, J Zhu
PloS one 2013
Ginsenoside RK3 Prevents Hypoxia-Reoxygenation Induced Apoptosis in H9c2 Cardiomyocytes via AKT and MAPK Pathway
J Sun, G Sun, X Meng, H Wang, M Wang, M Qin, B Ma, Y Luo, Y Yu, R Chen, Q Ai, X Sun
Evidence-Based Complementary and Alternative Medicine 2013
Bioactive Food as Dietary Interventions for Cardiovascular Disease
H Hwang, JP Konhilas
Bioactive Food as Dietary Interventions for Cardiovascular Disease 2013
Danshen mediates through estrogen receptors to activate Akt and inhibit apoptosis effect of Leu27IGF-II-induced IGF-II receptor signaling activation in cardiomyoblasts
YS Weng, WW Kuo, YM Lin, CH Kuo, BS Tzang, FJ Tsai, CH Tsai, JA Lin, DJ Hsieh, CY Huang
Food and Chemical Toxicology 2013
Valsartan attenuates oxidative stress and NF-κB activation and reduces myocardial apoptosis after ischemia and reperfusion
B Wu, R Lin, R Dai, C Chen, H Wu, M Hong
European Journal of Pharmacology 2013
Inhibition of apoptosis by the intrinsic but not the extrinsic apoptotic pathway in myocardial ischemia-reperfusion
AV Kristen, K Ackermann, S Buss, L Lehmann, PA Schnabel, A Haunstetter, HA Katus, SE Hardt
Cardiovascular Pathology 2013
Mesenchymal stem cell exosome ameliorates reperfusion injury through proteomic complementation
RC Lai, RW Yeo, KH Tan, SK Lim
Regenerative Medicine 2013
Cardiomyocyte apoptosis in the failing heart — A critical review from definition and classification of cell death
G Takemura, M Kanoh, S Minatoguchi, H Fujiwara
International Journal of Cardiology 2013
The Comparison of the Effects of Bretschneider's Histidine-Tryptophan-Ketoglutarate and Conventional Crystalloid Cardioplegia on Pediatric Myocardium at Tissue Level: Bretschneider's HTK and Conventional Crystalloid Cardioplegia
O Korun, M Özkan, A Terzi, G Aşkın, A Sezgin, S Aşlamacı
Artificial Organs 2013
Targeting cell death in the reperfused heart: Pharmacological approaches for cardioprotection
MI Oerlemans, S Koudstaal, SA Chamuleau, DP de Kleijn, PA Doevendans, JP Sluijter
International Journal of Cardiology 2013
Haschek and Rousseaux's Handbook of Toxicologic Pathology
BR Berridge, JF van Vleet, E Herman
Haschek and Rousseaux's Handbook of Toxicologic Pathology 2013
Effect and Mechanism of Propofol on Myocardial Ischemia Reperfusion Injury in Type 2 Diabetic Rats
C Lin, H Sui, J Gu, X Yang, L Deng, W Li, W Ding, D Li, Y Yang
Microvascular Research 2013
Involvement of cardiomyocyte apoptosis in myocardial injury of hereditary epileptic rats
F Chen, Y Cao, H Qi, L Li, W Huang, Y Wang, H Sun
Canadian Journal of Physiology and Pharmacology 2013
Hydrogen peroxide-responsive copolyoxalate nanoparticles for detection and therapy of ischemia–reperfusion injury
D Lee, S Bae, Q Ke, J Lee, B Song, SA Karumanchi, G Khang, HS Choi, PM Kang
Journal of Controlled Release 2013
Protective effect of CDP-choline on ischemia-reperfusion-induced myocardial tissue injury in rats
C Coskun, B Avci, M Yalcin, A Yermezler, MS Yilmaz, V Savci
Irish Journal of Medical Science 2013
Alpinetin activates the δ receptor instead of the κ and μ receptor pathways to protect against rat myocardial cell apoptosis
C Suo, L Sun, S Yang
Experimental and therapeutic medicine 2013
p53's choice of myocardial death or survival: Oxygen protects infarct myocardium by recruiting p53 on NOS3 promoter through regulation of p53-Lys(118) acetylation
R Gogna, E Madan, M Khan, U Pati, P Kuppusamy
EMBO Molecular Medicine 2013
H2O2-responsive molecularly engineered polymer nanoparticles as ischemia/reperfusion-targeted nanotherapeutic agents
D Lee, S Bae, D Hong, H Lim, JH Yoon, O Hwang, S Park, Q Ke, G Khang, PM Kang
Scientific Reports 2013
Z-disc transcriptional coupling, sarcomeroptosis and mechanoptosis [corrected]
R Knöll, B Buyandelger
Cell Biochemistry and Biophysics 2013
Combination of Epinephrine with Esmolol Attenuates Post-Resuscitation Myocardial Dysfunction in a Porcine Model of Cardiac Arrest
Q Zhang, CS Li, X Chen
PloS one 2013
Gene Therapy
S Nimesh
Gene Therapy 2013
Soluble TNF Receptors Are Associated with Infarct Size and Ventricular Dysfunction in ST-Elevation Myocardial Infarction
L Nilsson, A Szymanowski, E Swahn, L Jonasson, AJ Marian
PloS one 2013
Dynasore Protects Mitochondria and Improves Cardiac Lusitropy in Langendorff Perfused Mouse Heart
D Gao, L Zhang, R Dhillon, TT Hong, RM Shaw, J Zhu, R Mohanraj
PloS one 2013
Apoptosis Repressor with a CARD Domain (ARC) Restrains Bax-Mediated Pathogenesis in Dystrophic Skeletal Muscle
J Davis, JQ Kwong, RN Kitsis, JD Molkentin, MA Sussman
PloS one 2013
Pediatric and Congenital Cardiology, Cardiac Surgery and Intensive Care
EM da Cruz, D Ivy, J Jaggers
Pediatric and Congenital Cardiology, Cardiac Surgery and Intensive Care 2013
Isoflurane Preconditioning Confers Cardioprotection by Activation of ALDH2
XE Lang, X Wang, KR Zhang, JY Lv, JH Jin, QS Li, SR Singh
PloS one 2013
Prognostic Value of TNF-Related Apoptosis Inducing Ligand (TRAIL) in Acute Coronary Syndrome Patients
P Osmancik, E Teringova, P Tousek, P Paulu, P Widimsky, A Abbate
PloS one 2013
Cardiac Remodeling
BI Jugdutt, NS Dhalla
2013

← Previous 1 2 Next →

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Referenced in 10 patents
Referenced in 2 Wikipedia pages
154 readers on Mendeley
See more details