Citations to this article

Reperfusion injury induces apoptosis in rabbit cardiomyocytes.
R A Gottlieb, … , B M Babior, R L Engler
R A Gottlieb, … , B M Babior, R L Engler
Published October 1, 1994
Citation Information: J Clin Invest. 1994;94(4):1621-1628. https://doi.org/10.1172/JCI117504.
View: Text | PDF
Research Article Article has an altmetric score of 6

Reperfusion injury induces apoptosis in rabbit cardiomyocytes.

Abstract

The most effective way to limit myocardial ischemic necrosis is reperfusion, but reperfusion itself may result in tissue injury, which has been difficult to separate from ischemic injury. This report identifies elements of apoptosis (programmed cell death) in myocytes as a response to reperfusion but not ischemia. The hallmark of apoptosis, nucleosomal ladders of DNA fragments (approximately 200 base pairs), was detected in ischemic/reperfused rabbit myocardial tissue but not in normal or ischemic-only rabbit hearts. Granulocytopenia did not prevent nucleosomal DNA cleavage. In situ nick end labeling demonstrated DNA fragmentation predominantly in myocytes. The pattern of nuclear chromatin condensation was distinctly different in reperfused than in persistently ischemic tissue by transmission electron microscopy. Apoptosis may be a specific feature of reperfusion injury in cardiac myocytes, leading to late cell death.

Authors

R A Gottlieb, K O Burleson, R A Kloner, B M Babior, R L Engler

×

Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1988 1981 1977 Total
Citations: 3 2 10 12 13 12 23 19 25 33 24 28 33 37 37 34 41 30 42 37 48 50 67 45 65 66 63 52 53 31 16 2 1 1 1 1056
Citation information

Citations to this article in year 2012 (37)

Title and authors Publication Year
Regression of pathological cardiac hypertrophy: Signaling pathways and therapeutic targets
J Hou, YJ Kang 		Pharmacology & Therapeutics 2012
Genomics in cardiovascular diseases: analysis of the importance of the toll-like receptor signaling pathway
J Bustamante, E Tamayo, J Herreros 		International journal of general medicine 2012
Adora2b Signaling on Bone Marrow Derived Cells Dampens Myocardial Ischemia-Reperfusion Injury:
M Koeppen, PN Harter, S Bonney, M Bonney, S Reithel, C Zachskorn, M Mittelbronn, T Eckle 		Anesthesiology 2012
A Soluble Receptor for Advanced Glycation End-Products Inhibits Hypoxia/Reoxygenation-Induced Apoptosis in Rat Cardiomyocytes via the Mitochondrial Pathway
C Guo, X Zeng, J Song, M Zhang, H Wang, X Xu, F Du, B Chen 		International journal of molecular sciences 2012
Imaging Myocardial Ischemia and Reperfusion Injury via Cy5.5-Annexin V
R Tian, DF Pan 		Nuclear Medicine and Molecular Imaging 2012
MicroRNA-15a/b are up-regulated in response to myocardial ischemia/reperfusion injury
LF Liu, Z Liang, ZR Lv, XH Liu, J Bai, J Chen, C Chen, Y Wang 		Journal of Geriatric Cardiology 2012
Local Oxidative Stress Expansion through Endothelial Cells – A Key Role for Gap Junction Intercellular Communication
I Feine, I Pinkas, Y Salomon, A Scherz 		PloS one 2012
Intracoronary Levosimendan during Ischemia Prevents Myocardial Apoptosis
M Malmberg, T Vähäsilta, A Saraste, JW Koskenvuo, JP Pärkkä, K Leino, T Laitio, C Stark, A Heikkilä, P Saukko, T Savunen 		Frontiers in physiology 2012
Methods in Enzymology
JD Stone, AS Chervin, DH Aggen, DM Kranz 		Protein Engineering for Therapeutics Part B 2012
Contrast-enhanced MRI of murine myocardial infarction - Part I : CONTRAST-ENHANCED MRI OF MURINE MYOCARDIAL INFARCTION
T Geelen, LE Paulis, BF Coolen, K Nicolay, GJ Strijkers 		NMR in Biomedicine 2012
Extracellular and intracellular proteases in cardiac dysfunction due to ischemia–reperfusion injury
AL Müller, LV Hryshko, NS Dhalla 		International Journal of Cardiology 2012
Liposomes for cardiovascular targeting
TS Levchenko, WC Hartner, VP Torchilin 		Therapeutic Delivery 2012
GLP-1 and cardioprotection: from bench to bedside
S Ravassa, A Zudaire, J Diez 		Cardiovascular Research 2012
Muscle
ML Martin, SL Belmonte, R Ram, FA Kamal, BC Blaxall 		Muscle 2012
Liposomes in diagnosis and treatment of cardiovascular disorders
TS Levchenko, WC Hartner, VP Torchilin 		Methodist DeBakey Cardiovascular Journal 2012
Protection of the ischemic myocardium during the reperfusion: between hope and reality
JC Bopassa 		American Journal of Cardiovascular Disease 2012
Single intravenous low-dose injections of connexin 43 mimetic peptides protect ischemic heart in vivo against myocardial infarction
G Hawat, P Hélie, G Baroudi 		Journal of Molecular and Cellular Cardiology 2012
Delayed Postconditioning: Not Too Late?
S Barrère-Lemaire, J Nargeot, C Piot 		Trends in Cardiovascular Medicine 2012
Enhanced cell survival and diminished apoptotic response to simulated ischemia–reperfusion in H9c2 cells by magnetic field preconditioning
MV Kurian, L Hamilton, J Keeven, P Mehl, JM Mullins 		Apoptosis 2012
An Apoptosis Signal-regulating Kinase 1 Inhibitor Reduces Cardiomyocyte Apoptosis and Infarct Size in a Rat Ischemia-reperfusion Model:
PZ Gerczuk, DG Breckenridge, JT Liles, GR Budas, JC Shryock, L Belardinelli, RA Kloner, W Dai 		Journal of Cardiovascular Pharmacology 2012
Cardiac fibroblast death by ischemia/reperfusion is partially inhibited by IGF-1 through both PI3K/Akt and MEK–ERK pathways
R Vivar, C Humeres, M Varela, P Ayala, N Guzmán, I Olmedo, M Catalán, P Boza, C Muñoz, GD Araya 		Experimental and Molecular Pathology 2012
Nitric oxide preserves XIAP and reduces hypoxia/reoxygenation-induced cardiomyocytes apoptosis via ERK1/2 activation
H Yuan, B Yan, HH Wang, S Hua, A Hu 		Biochemical and Biophysical Research Communications 2012
Protective Role of Cardiac CFTR Activation Upon Early Reperfusion Against Myocardial Infarction
H Uramoto, T Okada, Y Okada 		Cellular Physiology and Biochemistry 2012
Trichostatin A Ameliorates Myocardial Ischemia/Reperfusion Injury Through Inhibition of Endoplasmic Reticulum Stress-induced Apoptosis
L Yu, M Lu, P Wang, X Chen 		Archives of Medical Research 2012
Reperfusion-triggered stress protein response in the myocardium is blocked by post-conditioning. Systems biology pathway analysis highlights the key role of the canonical aryl-hydrocarbon receptor pathway
G Vilahur, J Cubedo, L Casani, T Padro, M Sabate-Tenas, JJ Badimon, L Badimon 		European Heart Journal 2012
Madecassoside, a triterpenoid saponin isolated from Centella asiatica herbs, protects endothelial cells against oxidative stress
D Bian, M Liu, Y Li, Y Xia, Z Gong, Y Dai 		Journal of Biochemical and Molecular Toxicology 2012
Péptido similar al glucagón tipo 1 y supervivencia de la célula cardiaca
S Ravassa, A Zudaire, J Díez 		Endocrinología y Nutrición 2012
Effects of xenon and isoflurane on apoptosis and inflammation in a porcine myocardial infarction model
S Sopka, C Mertens, AB Roehl, K Schiffl, R Rossaint, I Classen-Linke 		Annals of Anatomy - Anatomischer Anzeiger 2012
Glucagon-like peptide 1 and cardiac cell survival
S Ravassa, A Zudaire, J Díez 		Endocrinología y Nutrición (English Edition) 2012
Epoxyeicosatrienoic acids protect rat hearts against tumor necrosis factor-α-induced injury
G Zhao, J Wang, X Xu, Y Jing, L Tu, X Li, C Chen, K Cianflone, P Wang, RT Dackor, DC Zeldin, DW Wang 		Journal of lipid research 2012
Redox-mediated programed death of myocardial cells after cardiac arrest and cardiopulmonary resuscitation
A Chalkias, T Xanthos 		Redox Report 2012
Local Oxidative Stress Expansion through Endothelial Cells – A Key Role for Gap Junction Intercellular Communication
I Feine, I Pinkas, Y Salomon, A Scherz, M Ushio-Fukai 		PloS one 2012
Strategic localization of heart mitochondrial NOS: a review of the evidence
T Zaobornyj, P Ghafourifar 		American journal of physiology. Heart and circulatory physiology 2012
Safety and efficacy of intracoronary adenosine administration in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention: a meta-analysis of randomized controlled trials
M Singh, T Shah, K Khosla, P Singh, J Molnar, S Khosla, R Arora 		Therapeutic advances in cardiovascular disease 2012
Mitochondria and Their Role in Cardiovascular Disease
J Marín-García 		2012
Atlas of Nuclear Cardiology
V Dilsizian, J Narula 		2012
Management of Myocardial Reperfusion Injury
JC Kaski, DJ Hausenloy, BJ Gersh, DM Yellon 		2012

Advertisement