Citations to this article

Reperfusion injury induces apoptosis in rabbit cardiomyocytes.
R A Gottlieb, … , B M Babior, R L Engler
R A Gottlieb, … , B M Babior, R L Engler
Published October 1, 1994
Citation Information: J Clin Invest. 1994;94(4):1621-1628. https://doi.org/10.1172/JCI117504.
View: Text | PDF
Research Article Article has an altmetric score of 6

Reperfusion injury induces apoptosis in rabbit cardiomyocytes.

Abstract

The most effective way to limit myocardial ischemic necrosis is reperfusion, but reperfusion itself may result in tissue injury, which has been difficult to separate from ischemic injury. This report identifies elements of apoptosis (programmed cell death) in myocytes as a response to reperfusion but not ischemia. The hallmark of apoptosis, nucleosomal ladders of DNA fragments (approximately 200 base pairs), was detected in ischemic/reperfused rabbit myocardial tissue but not in normal or ischemic-only rabbit hearts. Granulocytopenia did not prevent nucleosomal DNA cleavage. In situ nick end labeling demonstrated DNA fragmentation predominantly in myocytes. The pattern of nuclear chromatin condensation was distinctly different in reperfused than in persistently ischemic tissue by transmission electron microscopy. Apoptosis may be a specific feature of reperfusion injury in cardiac myocytes, leading to late cell death.

Authors

R A Gottlieb, K O Burleson, R A Kloner, B M Babior, R L Engler

×

Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1988 1981 1977 Total
Citations: 3 2 10 12 13 12 23 19 25 33 24 28 33 37 37 34 41 30 42 37 48 50 67 45 65 66 63 52 53 31 16 2 1 1 1 1056
Citation information

Citations to this article in year 2010 (34)

Title and authors Publication Year
Activation of calcium-sensing receptors is associated with apoptosis in a model of simulated cardiomyocytes ischemia/reperfusion
L Yan, T Zhu, T Sun, L Wang, S Pan, Z Tao, Z Yang, K Cao 		Journal of Biomedical Research 2010
Cellular stress responses: cell survival and cell death
S Fulda, AM Gorman, O Hori, A Samali 		International Journal of Cell Biology 2010
Protein Kinases as Drug Development Targets for Heart Disease Therapy
NS Dhalla, AL Müller 		Pharmaceuticals (Basel, Switzerland) 2010
Netrin-1 prevents ischemia/reperfusion-induced myocardial infarction via a DCC/ERK1/2/eNOS s1177/NO/DCC feed-forward mechanism
J Zhang, H Cai 		Journal of Molecular and Cellular Cardiology 2010
Pim-1 Kinase Protects Mitochondrial Integrity in Cardiomyocytes
GA Borillo, M Mason, P Quijada, M Völkers, C Cottage, M McGregor, S Din, K Fischer, N Gude, D Avitabile, S Barlow, R Alvarez, S Truffa, R Whittaker, MS Glassy, AB Gustafsson, S Miyamoto, CC Glembotski, RA Gottlieb, JH Brown, MA Sussman 		Circulation research 2010
Cell Death in the Pathogenesis of Heart Disease: Mechanisms and Significance
RS Whelan, V Kaplinskiy, RN Kitsis 		Annual Review of Physiology 2010
How to Mediate Cardioprotection in Ischemic Hearts—Accumulated Evidence of Basic Research Should Translate to Clinical Medicine
M Kitakaze 		Cardiovascular Drugs and Therapy 2010
Sevoflurane postconditioning prevents activation of caspase 3 and 9 through antiapoptotic signaling after myocardial ischemia–reperfusion
Y Inamura, M Miyamae, S Sugioka, N Domae, J Kotani 		Journal of Anesthesia 2010
Small-animal SPECT and SPECT/CT: application in cardiovascular research
R Golestani, C Wu, RA Tio, CJ Zeebregts, AD Petrov, FJ Beekman, RA Dierckx, HH Boersma, RH Slart 		European Journal of Nuclear Medicine and Molecular Imaging 2010
Connexin 43 mimetic peptide Gap26 confers protection to intact heart against myocardial ischemia injury
G Hawat, M Benderdour, G Rousseau, G Baroudi 		Pflügers Archiv - European Journal of Physiology 2010
Apoptosis in Cardiovascular Diseases: Mechanism and Clinical Implications
NH Kim, PM Kang 		Korean Circulation Journal 2010
Imaging of apoptosis in the heart with nanoparticle technology
HH Chen, L Josephson, DE Sosnovik 		Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 2010
In Vivo Fluorometric Assessment of Cyclosporine on Mitochondrial Function During Myocardial Ischemia and Reperfusion
M Matsubara, M Ranji, BG Leshnower, M Noma, SJ Ratcliffe, B Chance, RC Gorman, JH 3rd 		The Annals of Thoracic Surgery 2010
PAF exerts a direct apoptotic effect on the rat H9c2 cardiomyocytes in Ca2+-dependent manner
D Zhao, WF Chu, L Wu, J Li, QM Liu, YJ Lu, GF Qiao, ZG Wang, ZR Zhang, BF Yang 		International Journal of Cardiology 2010
Attenuating Ischemia-Induced H9c2 Myoblasts Apoptosis by Therapeutic Hypothermia
CH Lin, WS Wu, MT Lin, WP Liu, RB Hsu, CP Chang 		The American Journal of the Medical Sciences 2010
The Role of the Transcription Factor Nuclear Factor Kappa B in the Regulation of Cardiac Hypertrophy
D Sorriento, G Iaccarino, B Trimarco 		High Blood Pressure & Cardiovascular Prevention 2010
Reduction of Myocardial Ischemia-Reperfusion Injury by Mechanical Tissue Resuscitation Using Sub-Atmospheric Pressure
LC Argenta, MJ Morykwas, JJ Mays, EA Thompson, JW Hammon, JE Jordan 		Journal of Cardiac Surgery 2010
Apoptosis is not involved in the mechanism of myocardial dysfunction after resuscitation in a rat model of cardiac arrest and cardiopulmonary resuscitation
F Song, Y Shan, F Cappello, F Rappa, G Ristagno, T Yu, GL Volti, S Sun, MH Weil, W Tang 		Critical Care Medicine 2010
The role of p53, bax, bcl2, and 8-OHdG in human acute myocardial infarction
RA Najar, SM Ghaderian, H Vakili, AS Panah, AR Farimani, G Rezaie, AB Harchegani 		Central European Journal of Biology 2010
Indomethacin Reduces Cell Damage: Shedding New Light on Compartment Syndrome
A Manjoo, D Sanders, A Lawendy, M Gladwell, D Gray, N Parry, A Badhwar 		Journal of Orthopaedic Trauma 2010
Antiapoptotic potential of herbal drugs in cardiovascular disorders: An overview
R Ahmad, S Javed, U Bhandari 		Pharmaceutical Biology 2010
Cardioprotective properties of Crataegus oxycantha extract against ischemia-reperfusion injury
JK Swaminathan, M Khan, IK Mohan, K Selvendiran, SN Devaraj, BK Rivera, P Kuppusamy 		Phytomedicine : international journal of phytotherapy and phytopharmacology 2010
Myocardium and microvessel endothelium apoptosis at day 7 following reperfused acute myocardial infarction
S Kang, Y Yang, Y Wu, Y Chen, L Li, Y Tian 		Microvascular Research 2010
Cardioprotective activity of urocortin by preventing caspase-independent, non-apoptotic death in cultured neonatal rat cardiomyocytes exposed to ischemia
T Takatani-Nakase, K Takahashi 		Biochemical and Biophysical Research Communications 2010
Curculigoside attenuates human umbilical vein endothelial cell injury induced by H2O2
YK Wang, YJ Hong, M Wei, Y Wu, ZQ Huang, RZ Chen, HZ Chen 		Journal of Ethnopharmacology 2010
Activation of Bone Remodeling after Fatigue: Differential Response to Linear Microcracks and Diffuse Damage
BC Herman, L Cardoso, RJ Majeska, KJ Jepsen, MB Schaffler 		Bone 2010
Vitamins & Hormones
KJ Hare, FK Knop 		Vitamins & Hormones 2010
Biomarkers: In Medicine, Drug Discovery, and Environmental Health
AS McLean, SJ Huang 		Biomarkers: In Medicine, Drug Discovery, and Environmental Health 2010
Sirolimus in Kidney Transplant Donors and Clinical and Histologic Improvement in Recipients: Rat Model
F Cicora, N Lausada, DN Vasquez, P Cicora, G Zalazar, P Gonzalez, G Palti, C Raimondi 		Transplantation Proceedings 2010
Trimetazidine, Administered at the Onset of Reperfusion, Ameliorates Myocardial Dysfunction and Injury by Activation of p38 Mitogen-Activated Protein Kinase and Akt Signaling
M Khan, S Meduru, M Mostafa, S Khan, K Hideg, P Kuppusamy 		The Journal of pharmacology and experimental therapeutics 2010
Herba Epimedii: Anti-Oxidative Properties and Its Medical Implications
SC Sze, Y Tong, TB Ng, CL Cheng, HP Cheung 		Molecules (Basel, Switzerland) 2010
Cancer Nanotechnology
SR Grobmyer, BM Moudgil 		Cancer Nanotechnology 2010
Studies on Cardiovascular Disorders
H Sauer, AM Shah, FR Laurindo 		2010
New Solutions for the Heart
BK Podesser, DJ Chambers 		2010

Advertisement