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Citations to this article

Reperfusion injury induces apoptosis in rabbit cardiomyocytes.
R A Gottlieb, … , B M Babior, R L Engler
R A Gottlieb, … , B M Babior, R L Engler
Published October 1, 1994
Citation Information: J Clin Invest. 1994;94(4):1621-1628. https://doi.org/10.1172/JCI117504.
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Research Article Article has an altmetric score of 6

Reperfusion injury induces apoptosis in rabbit cardiomyocytes.

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Abstract

The most effective way to limit myocardial ischemic necrosis is reperfusion, but reperfusion itself may result in tissue injury, which has been difficult to separate from ischemic injury. This report identifies elements of apoptosis (programmed cell death) in myocytes as a response to reperfusion but not ischemia. The hallmark of apoptosis, nucleosomal ladders of DNA fragments (approximately 200 base pairs), was detected in ischemic/reperfused rabbit myocardial tissue but not in normal or ischemic-only rabbit hearts. Granulocytopenia did not prevent nucleosomal DNA cleavage. In situ nick end labeling demonstrated DNA fragmentation predominantly in myocytes. The pattern of nuclear chromatin condensation was distinctly different in reperfused than in persistently ischemic tissue by transmission electron microscopy. Apoptosis may be a specific feature of reperfusion injury in cardiac myocytes, leading to late cell death.

Authors

R A Gottlieb, K O Burleson, R A Kloner, B M Babior, R L Engler

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1988 1981 1977 Total
Citations: 4 2 10 12 13 12 23 19 25 33 24 28 33 37 37 34 41 30 42 37 48 50 67 45 65 66 63 52 53 31 16 2 1 1 1 1057
Citation information
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Citations to this article in year 2004 (50)

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Y Akamatsu, M Haga, S Tyagi, K Yamashita, AV GraçaSouza, R Ollinger, E Czismadia, GA May, E Ifedigbo, LE Otterbein, FH Bach, MP Soares
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U Savla
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J Marn-Garca, MJ Goldenthal
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Nitric oxide and promotion of cardiac myocyte apoptosis
P Andréka, T Tran, KA Webster, NH Bishopric
Molecular and Cellular Biochemistry 2004
Functional and clinical repercussions of myocyte apoptosis in the multifaceted damage by ischemia/reperfusion injury: old and new concepts after 10 years of contributions
TM Scarabelli, RA Gottlieb
Cell Death and Differentiation 2004
Multiple deficiencies in antioxidant enzymes in mice result in a compound increase in sensitivity to oxidative stress
HV Remmen, W Qi, M Sabia, G Freeman, L Estlack, H Yang, ZM Guo, TT Huang, R Strong, S Lee, CJ Epstein, A Richardson
Free radical biology & medicine 2004
Inhibition of c-Jun N-terminal kinase decreases cardiomyocyte apoptosis and infarct size after myocardial ischemia and reperfusion in anaesthetized rats
C Ferrandi, R Ballerio, P Gaillard, C Giachetti, S Carboni, PA Vitte, JP Gotteland, R Cirillo
British Journal of Pharmacology 2004
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PP Babu, G Suzuki, Y Ono, Y Yoshida
Pathology International 2004
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M Siemionow, E Arslan
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Inhaled nitric oxide attenuates apoptosis in ischemia-reperfusion injury of the rabbit lung
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Transient and reversible deoxyribonucleic acid damage in human left ventricle under controlled ischemia and reperfusion
GG Corbucci, C Perrino, G Donato, A Ricchi, B Lettieri, G Troncone, C Indolfi, M Chiariello, EV Avvedimento
Journal of the American College of Cardiology 2004
Mitochondrial Permeability Transition in Cardiomyocyte Apoptosis during Acute Graft Rejection
O Raisky, L Gomez, L Chalabreysse, O Gateau-Roesch, J Loufouat, F Thivolet-Bejui, J Ninet, M Ovize
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YS Jung, YS Jung, MY Kim, E Kim
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G Takemura, H Fujiwara
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Brain Research Reviews 2004
Nitric oxide: a signaling molecule against mitochondrial permeability transition- and pH-dependent cell death after reperfusion
JS Kim, S Ohshima, P Pediaditakis, JJ Lemasters
Free radical biology & medicine 2004
Apoptosis: Pathophysiology and therapeutic implications for the cardiac surgeon
A Khoynezhad, Z Jalali, AJ Tortolani
The Annals of Thoracic Surgery 2004
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Proceedings of the National Academy of Sciences 2004
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BI Jugdutt
Experimental and clinical cardiology 2004
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Life Sciences 2004
Reduction of infarct size and preservation of endothelial function by multidose intravenous adenosine during extended reperfusion
JM Budde, CD Morris, DA Velez, S Muraki, NP Wang, RA Guyton, ZQ Zhao
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Nutritional supplementation with mixed essential amino acids enhances myocyte survival, preserving mitochondrial functional capacity during ischemia-reperfusion injury
TM Scarabelli, E Pasini, A Stephanou, C Chen-Scarabelli, L Saravolatz, RA Knight, DS Latchman, JM Gardin
The American Journal of Cardiology 2004
Synthesis and evaluation of anti-apoptotic activity of L-carnitine cyclic analogues and amino acid derivatives
R Fringuelli, MP Navarro, L Milanese, S Bruscoli, F Schiaffella, C Riccardi, CD Simone
Il Farmaco 2004
Initiation of mitochondrial-mediated apoptosis during cardiac reperfusion
KC Lundberg, LI Szweda
Archives of Biochemistry and Biophysics 2004
Local delivery of soluble TNF-alpha receptor 1 gene reduces infarct size following ischemia/reperfusion injury in rats
M Sugano, T Hata, K Tsuchida, N Suematsu, JI Oyama, S Satoh, N Makino
Molecular and Cellular Biochemistry 2004
Overexpression of mitogen-activated protein kinase kinase 6 in the heart improves functional recovery from ischemia in vitro and protects against myocardial infarction in vivo
JJ Martindale, JA Wall, DM Martinez-Longoria, P Aryal, HA Rockman, Y Guo, R Bolli, CC Glembotski
The Journal of biological chemistry 2004
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VG Florea, J Moon, DJ Pennell, W Doehner, AJ Coats, SD Anker
International Journal of Cardiology 2004
Taurine prevents the ischemia-induced apoptosis in cultured neonatal rat cardiomyocytes through Akt/caspase-9 pathway
T Takatani, K Takahashi, Y Uozumi, T Matsuda, T Ito, SW Schaffer, Y Fujio, J Azuma
Biochemical and Biophysical Research Communications 2004
Cell death in cartilage
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Post-Ischemic Cardioprotection by A2A Adenosine Receptors: Dependent of Phosphatidylinositol 3-Kinase Pathway:
M Boucher, S Pesant, S Falcao, C Montigny, É Schampaert, R Cardinal, G Rousseau
Journal of Cardiovascular Pharmacology 2004
Minoxidil Attenuates Ischemia-Induced Apoptosis in Cultured Neonatal Rat Cardiomyocytes:
T Takatani, K Takahashi, C Jin, T Matsuda, X Cheng, T Ito, J Azuma
Journal of Cardiovascular Pharmacology 2004
Apoptosis Repressor with Caspase Recruitment Domain Protects against Cell Death by Interfering with Bax Activation
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Taurine inhibits apoptosis by preventing formation of the Apaf-1/caspase-9 apoptosome
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Differential contribution of necrosis and apoptosis in myocardial ischemia-reperfusion injury
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The Role of Oxygen-Free Radical in the Apoptosis of Enterocytes in Scalded Rats After Delayed Resuscitation:
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2004
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