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Citations to this article

Absence of gamma interferon and interleukin 2 production during active visceral leishmaniasis.
E M Carvalho, … , T C Jones, W D Johnson Jr
E M Carvalho, … , T C Jones, W D Johnson Jr
Published December 1, 1985
Citation Information: J Clin Invest. 1985;76(6):2066-2069. https://doi.org/10.1172/JCI112209.
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Absence of gamma interferon and interleukin 2 production during active visceral leishmaniasis.

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Abstract

The lymphocytes from eight patients with active visceral leishmaniasis (VL), a disease associated with marked immunologic dysfunction, were examined for ability to produce interleukin 2 (IL-2) and gamma interferon during in vitro cultivation. It was found that both IL-2 and gamma interferon production, in response to leishmania antigen, was absent during the active disease, but was restored after successful chemotherapy. Untreated VL patients produced IL-2 and gamma interferon when stimulated with phytohemagglutinin (PHA). Six patients with either active cutaneous or mucosal leishmaniasis, a disease not associated with immunosuppression, showed high levels of gamma interferon in response to leishmania antigen and PHA. Since IL-2 and gamma interferon have been shown to have important roles in the immune response and in the killing of leishmania, their absence may represent a key defect in the immune response in VL.

Authors

E M Carvalho, R Badaró, S G Reed, T C Jones, W D Johnson Jr

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S El-Safi, MM Kheir, B Bucheton, L Argiro, L Abel, J Dereure, JP Dedet, A Dessein
Comptes Rendus Biologies 2006
Estudo comparativo de anticorpos IgG e IgE antileishmania como marcadores de infecção e doença em indivíduos de área endêmica de leishmaniose visceral, em São Luis, MA
MD Nascimento, GF de Bezerra, AP Neto, LM da Silva, JM Bezerra, GM de Viana
Revista da Sociedade Brasileira de Medicina Tropical 2006
Inhibition of IL-2 Induced IL-10 Production as a Principle of Phase-Specific Immunotherapy
M Bodas, N Jain, A Awasthi, S Martin, RK Loka, D Dandekar, D Mitra, B Saha
Journal of immunology (Baltimore, Md. : 1950) 2006
Identification of a novel G245R polymorphism in the IL-2 receptor beta membrane proximal domain associated with human visceral leishmaniasis.
Bucheton B, Argiro L, Chevillard C, Marquet S, Kheir MM, Mergani A, El-Safi SH, Dessein AJ
Genes and immunity 2006
Interleukin-12 augments a Th1-type immune response manifested as lymphocyte proliferation and interferon gamma production in Leishmania infantum-infected dogs
D Strauss-Ayali, G Baneth, S Shor, F Okano, CL Jaffe
International Journal for Parasitology 2005
INFLUENCE OF PHOSPHOLIPID COMPOSITION ON THE ADJUVANTICITY AND PROTECTIVE EFFICACY OF LIPOSOME-ENCAPSULATED LEISHMANIA DONOVANI ANTIGENS
T Mazumdar, K Anam, N Ali
Journal of Parasitology 2005
Induction of Interferon-Gamma (IFN-γ) and T Helper 1 (Th1) Immune Response by Bitter Gourd Extract
K IKE, Y UCHIDA, T NAKAMURA, S IMAI
Journal of Veterinary Medical Science 2005
Immunoglobulin G and E responses in various stages of canine leishmaniosis
L Iniesta, M Gállego, M Portús
Veterinary Immunology and Immunopathology 2005
Leishmania donovani: identification of novel vaccine candidates using human reactive sera and cell lines
SK Arora, NS Pal, S Mujtaba
Experimental Parasitology 2005
Leishmania infantum: soluble proteins released by the parasite exert differential effects on host immune response
R Rosa, OR Rodrigues, C Marques, GM Santos-Gomes
Experimental Parasitology 2005
Balance of IL-10 and Interferon-γ plasma levels in human visceral leishmaniasis: Implications in the pathogenesis
A Caldas, C Favali, D Aquino, V Vinhas, J Weyenbergh, C Brodskyn, J Costa, M Barral-Netto, A Barral
BMC Infectious Diseases 2005
Kinetoplastid Membrane Protein-11 DNA Vaccination Induces Complete Protection against Both Pentavalent Antimonial-Sensitive and -Resistant Strains of Leishmania donovani That Correlates with Inducible Nitric Oxide Synthase Activity and IL-4 Generation: Evidence for Mixed Th1- and Th2-Like Responses in Visceral Leishmaniasis
R Basu, S Bhaumik, JM Basu, K Naskar, T De, S Roy
Journal of immunology (Baltimore, Md. : 1950) 2005
Mechanisms of the Natural Reactivity of Lymphocytes from Noninfected Individuals to Membrane-Associated Leishmania infantum Antigens
A Sassi, B Larguèche-Darwaz, A Collette, A Six, D Laouini, PA Cazenave, K Dellagi
Journal of immunology (Baltimore, Md. : 1950) 2005
Recombinant Leishmania Antigens for Serodiagnosis of Visceral Leishmaniasis
S Passos, LP Carvalho, G Orge, SM Jerônimo, G Bezerra, M Soto, C Alonso, EM Carvalho
Clinical and vaccine immunology : CVI 2005
CD4+ CCR5+ and CD4+ CCR3+ lymphocyte subset and monocyte apoptosis in patients with acute visceral leishmaniasis
M Potestio, P D'Agostino, GC Romano, S Milano, V Ferlazzo, A Aquino, GD Bella, R Caruso, G Gambino, G Vitale, S Mansueto, E Cillari
Immunology 2004
A mixed Th1/Th2 response elicited by a liposomal formulation of Leishmania vaccine instructs Th1 responses and resistance to Leishmania donovani in susceptible BALB/c mice
T Mazumdar, K Anam, N Ali
Vaccine 2004
Interleukin-15, as Interferon-gamma, Induces the Killing of Leishmania infantum in Phorbol-Myristate-Acetate-Activated Macrophages Increasing Interleukin-12
P D'Agostino, S Milano, F Arcoleo, GD Bella, ML Rosa, V Ferlazzo, R Caruso, N Chifari, G Vitale, S Mansueto, E Cillari
Scandinavian Journal of Immunology 2004
Zinc/copper imbalance reflects immune dysfunction in human leishmaniasis: an ex vivo and in vitro study
JV Weyenbergh, G Santana, A D'Oliveira, AF Santos, CH Costa, EM Carvalho, A Barral, M Barral-Netto
BMC Infectious Diseases 2004
Characterization of immunoglobulin G and its subclass response to Indian kala-azar infection before and after chemotherapy
R Ravindran, K Anam, BC Bairagi, B Saha, N Pramanik, SK Guha, RP Goswami, D Banerjee, N Ali
Infection and immunity 2004
Intake of nutrient supplements affects multiplication of Leishmania donovani in hamsters
R Garg, N Singh, A Dube
Parasitology 2004
A Major Susceptibility Locus on Chromosome 22q12 Plays a Critical Role in the Control of Kala-Azar
B Bucheton, L Abel, S El-Safi, MM Kheir, S Pavek, A Lemainque, AJ Dessein
The American Journal of Human Genetics 2003
Infection of Human Mononuclear Phagocytes and Macrophage-Like THP1 Cells with Leishmania donovani Results in Modulation of Expression of a Subset of Chemokines and a Chemokine Receptor
B Dasgupta, K Roychoudhury, S Ganguly, MA Akbar, P Das, S Roy
Scandinavian Journal of Immunology 2003
Characterization of the immune response to Leishmania infantum recombinant antigens
LP de Carvalho, M Soto, S Jerônimo, B Dondji, O Bacellar, V Luz, GO Orge, C Alonso, AR Jesus, EM Carvalho
Microbes and Infection 2003
Experimental canine leishmaniasis: evolution of infection following re-challenge with Leishmania infantum
GM Santos-Gomes, MJ Capela, J Ramada, L Campino
Acta Tropica 2003
Immunosuppression in Hamsters with Progressive Visceral Leishmaniasis Is Associated with an Impairment of Protein Kinase C Activity in Their Lymphocytes That Can Be Partially Reversed by Okadaic Acid or Anti-Transforming Growth Factor β Antibody
A Mookerjee, PC Sen, AC Ghose
Infection and immunity 2003
Immune complex antigens as a tool in serodiagnosis of kala-azar
Tapati Chakraborti, Dwijen Sarkar, Dilip K Ghosh
Molecular and Cellular Biochemistry 2003
Alteration of Fas and Fas ligand expression during human visceral leishmaniasis
L Eidsmo, D Wolday, N Berhe, F Sabri, I Satti, AM el Hassan, S Sundar, F Chiodi, H Akuffo
Clinical & Experimental Immunology 2002
IL-15 in human visceral leishmaniasis caused by Leishmania infantum
S Milano, GD Bella, P D'Agostino, C Barbera, R Caruso, ML Rosa, V Ferlazzo, G Vitale, CL Russa, G Gambino, N Chifari, S Mansueto, E Cillari
Clinical & Experimental Immunology 2002
Cytokine expression during the outcome of canine experimental infection by Leishmania infantum
GM Santos-Gomes, R Rosa, C Leandro, S Cortes, P Romão, H Silveira
Veterinary Immunology and Immunopathology 2002
Predictors of an unsatisfactory response to pentavalent antimony in the treatment of American visceral leishmaniasis
MA Santos, RC Marques, CA Farias, DM Vasconcelos, JM Stewart, DL Costa, CH Costa
Revista da Sociedade Brasileira de Medicina Tropical 2002
Immunoglobulin E Antileishmanial Antibody Response in Cutaneous Leishmaniasis
ML Sousa-Atta, GS Salamé, A DOliveira, RP Almeida, AM Atta, EM Carvalho
Clinical and vaccine immunology : CVI 2002
Successful vaccination against Leishmania donovani infection in Indian langur using alum-precipitated autoclaved Leishmania major with BCG
A Misra, A Dube, B Srivastava, P Sharma, JK Srivastava, JC Katiyar, S Naik
Vaccine 2001
Leishmania donovani: Evolution and Architecture of the Splenic Cellular Immune Response Related to Control of Infection
PC Melby, A Tabares, BI Restrepo, AE Cardona, HS McGuff, JM Teale
Experimental Parasitology 2001
Association analysis of HLA-Class iI and class iII gene polymorphisms in the susceptibility to mediterranean visceral leishmaniasis
A Meddeb-Garnaoui, S Gritli, S Garbouj, MB Fadhel, RE Kares, L Mansour, B Kaabi, L Chouchane, AB Salah, K Dellagi
Human Immunology 2001
The Hamster as a Model of Human Visceral Leishmaniasis: Progressive Disease and Impaired Generation of Nitric Oxide in the Face of a Prominent Th1-Like Cytokine Response
PC Melby, B Chandrasekar, W Zhao, JE Coe
Journal of immunology (Baltimore, Md. : 1950) 2001
Dual Role of the Leishmania major Ribosomal Protein S3a Homologue in Regulation of T- and B-Cell Activation
JM Mansfield, A Cordeiro-da-Silva, MC Borges, E Guilvard, A Ouaissi
Infection and immunity 2001
Bronchopulmonary and Mediastinal Leishmaniasis: An Unusual Clinical Presentation of Leishmania donovani Infection
BG Marshall, P Kropf, K Murray, C Clark, AM Flanagan, RN Davidson, RJ Shaw, I Muller
Clinical Infectious Diseases 2000
Identification of a 30 kDa antigen from Leishmania (L.) chagasi amastigotes implicated in protective cellular reponses in a murine model
AR Pinto, CG Beyrodt, RA Lopes, CL Barbiéri
International Journal for Parasitology 2000
IL-10 AND IL-12 ARE THE MAIN REGULATORY CYTOKINES IN VISCERAL LEISHMANIASIS
O Bacellar, A D'oliveira, S Jerônimo, EM Carvalho
Cytokine 2000
The development of post-kala-azar dermal leishmaniasis (PKDL) is associated with acquisition of Leishmania reactivity by peripheral blood mononuclear cells (PBMC)
S Gasim, AM Elhassan, A Kharazmi, EA Khalil, A Ismail, TG Theander
Clinical & Experimental Immunology 2000
Treatment of visceral leishmaniasis (kala-azar): A decade of progress and future approaches
HW Murray
International Journal of Infectious Diseases 2000
HIV-1 alters T helper cytokines, interleukin-12 and interleukin-18 responses to the protozoan parasite Leishmania donovani:
D Wolday, N Berhe, S Britton, H Akuffo
AIDS 2000
Role of CD8+ T cells in endogenous interleukin-10 secretion associated with visceral leishmaniasis
BJ Holaday
Memórias do Instituto Oswaldo Cruz 2000
A Novel Leishmania infantum Recombinant Antigen Which Elicits Interleukin 10 Production by Peripheral Blood Mononuclear Cells of Patients with Visceral Leishmaniasis
TR Kozel, I Suffia, B Ferrua, X Stien, B Mograbi, P Marty, D Rousseau, K Fragaki, J Kubar
Infection and immunity 2000
TGF-β Mediates CTLA-4 Suppression of Cellular Immunity in Murine Kalaazar
NA Gomes, CR Gattass, V Barreto-de-Souza, ME Wilson, GA DosReis
Journal of immunology (Baltimore, Md. : 1950) 2000
Les leishmanioses: un modèle d'étude des interactions hôte-parasite; implications pour la maladie humaine
H Louzir, K Dellagi
Annales de l'Institut Pasteur/Actualités 1999
Leishmania-specific T cells expressing interferon-gamma (IFN-gamma) and IL-10 upon activation are expanded in individuals cured of visceral leishmaniasis
K Kemp, M Kemp, A Kharazmi, A Ismail, JA Kurtzhals, L Hviid, TG Theander
Clinical & Experimental Immunology 1999
Differential decline in Leishmania membrane antigen-specific immunoglobulin G (IgG), IgM, IgE, and IgG subclass antibodies in Indian kala-azar patients after chemotherapy
K Anam, F Afrin, D Banerjee, N Pramanik, SK Guha, RP Goswami, SK Saha, N Ali
Infection and immunity 1999
TGF-β in infections and infectious diseases
SG Reed
Microbes and Infection 1999
T-cell response in human leishmaniasis
A Kharazmi, K Kemp, A Ismail, S Gasim, A Gaafar, JA Kurtzhals, AM Hassan, TG Theander, M Kemp
Immunology Letters 1999
The immune response and PBMC subsets in canine visceral leishmaniasis before, and after, chemotherapy
J Moreno, J Nieto, C Chamizo, F González, F Blanco, DC Barker, J Alvar
Veterinary Immunology and Immunopathology 1999
Leishmania–HIV Interaction: Immunopathogenic Mechanisms
D Wolday, N Berhe, H Akuffo, S Britton
Parasitology Today 1999
Traitement de la leishmaniose viscérale infantile
P Minodier, F Faraut-Gambarelli, R Piarroux, C Gire, JM Garnier, H Dumon
Archives de Pédiatrie 1999
T Cell Response of Asymptomatic Leishmania chagasi Infected Subjects to Recombinant Leishmania Antigens
SR Costa, AD Júnior, O Bacellar, EM Carvalho
Memórias do Instituto Oswaldo Cruz 1999
A dhfr-ts- Leishmania major Knockout Mutant Cross-protects against Leishmania amazonensis
PS Veras, CI Brodskyn, FM Balestieri, LA Freitas, AP Ramos, AR Queiroz, A Barral, SM Beverley, M Barral-Netto
Memórias do Instituto Oswaldo Cruz 1999
Differential Decline in Leishmania Membrane Antigen-Specific Immunoglobulin G (IgG), IgM, IgE, and IgG Subclass Antibodies in Indian Kala-Azar Patients after Chemotherapy
SH Kaufmann, K Anam, F Afrin, D Banerjee, N Pramanik, SK Guha, RP Goswami, SK Saha, N Ali
Infection and immunity 1999
Immunoglobulin Subclass Distribution and Diagnostic Value of Leishmania donovani Antigen-Specific Immunoglobulin G3 in Indian Kala-Azar Patients
K Anam, F Afrin, D Banerjee, N Pramanik, SK Guha, RP Goswami, PN Gupta, SK Saha, N Ali
Clinical and diagnostic laboratory immunology 1999
Distribution of IgG subclasses in antimonial unresponsive Indian kala-azar patients
M Chatterjee, K Basu, D Basu, D Bannerjee, N Pramanik, SK Guha, RP Goswami, SK Saha, C Mandal
Clinical & Experimental Immunology 1998
Human_Leishmaniasis@cytokines.bahia.br
M Barral-Netto, C Brodskyn, EM Carvalho, A Barral
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica ... [et al.] 1998
Presence of Circulating Levels of Interferon-g, Interleukin-10 and Tumor Necrosis Factor-a in Patients with Visceral Leishmaniasis
IM de MEDEIROS, A CASTELO, R SALOMÃO
Revista do Instituto de Medicina Tropical de São Paulo 1998
Human and Murine Immune Responses to a Novel Leishmania major Recombinant Protein Encoded by Members of a Multicopy Gene Family
JR Webb, A Campos-Neto, PJ Ovendale, TI Martin, EJ Stromberg, R Badaro, SG Reed
Infection and immunity 1998
Regional Differences in the Cellular Immune Response to Experimental Cutaneous or Visceral Infection with Leishmania donovani
PC Melby, YZ Yang, J Cheng, W Zhao
Infection and immunity 1998
Successful therapy of chronic, nonhealing murine cutaneous leishmaniasis with sodium stibogluconate and gamma interferon depends on continued interleukin-12 production
J Li, S Sutterwala, JP Farrell
Infection and immunity 1997
Adjuvanticity and protective immunity elicited by Leishmania donovani antigens encapsulated in positively charged liposomes
F Afrin, N Ali
Infection and immunity 1997
Regulator and effector functions of T-cell subsets in human Leishmanaia infections
M Kemp
APMIS 1997
Type 1 and type 2 cytokine dysregulation in human infectious, neoplastic, and inflammatory diseases
DR Lucey, M Clerici, GM Shearer
Clinical microbiology reviews 1996
Reversibility of T helper 1 and 2 populations is lost after long-term stimulation
E Murphy, K Shibuya, N Hosken, P Openshaw, V Maino, K Davis, K Murphy, A O'Garra
Journal of Experimental Medicine 1996
VISCERAL LEISHMANIASIS
ME Wilson, JA Streit
Gastroenterology Clinics of North America 1996
The contrasting roles of CD4+ T cells in intracellular infections in humans: leishmaniasis as an example
M Kemp, TG Theander, A Kharazmi
Immunology Today 1996
Histopathology and immunocytochemical study of type 3 and type 4 complement receptors in the liver and spleen of dogs naturally and experimentally infected with Leishmania (Leishmania) chagasi
WL Tafuri, WL Tafuri, AJ Barbosa, MS Michalick, O Genaro, JC França-Silva, W Mayrink, E Nascimento
Revista do Instituto de Medicina Tropical de São Paulo 1996
Subpopulations of T Lymphocytes in the Peripheral Blood, Dermal Lesions and Lymph Nodes of Post Kala-azar Dermal Leishmaniasis Patients
MK Ghosh, A Nandy, M Addy, TK Maitra, AC Ghose
Scandinavian Journal of Immunology 1995
Interleukin-4 and Interferon-Gamma Production by Leishmania Stimulated Peripheral Blood Mononuclear Cells from Nonexposed Individuals
JA Kurtzhals, M Kemp, LK Poulsen, MB Hansen, A Kharazmi, TG Theander
Scandinavian Journal of Immunology 1995
Immunotherapy with IL-2-stimulated splenocytes reduces in vitro the level of Leishmania donovani infection in peritoneal macrophages
Z Eslami, M Olivier, CE Tanner
International Journal for Parasitology 1995
Differing antibody IgG isotypes in the polar forms of leprosy and cutaneous leishmaniasis characterized by antigen-specific T cell anergy
M Ulrich, V Rodriguez, M Centeno, J Convit
Clinical & Experimental Immunology 1995
Serum soluble markers in the evaluation of treatment in human visceral leishmaniasis
A Schriefer, A Barral, EM Carvalho, M Barral-Netto
Clinical & Experimental Immunology 1995
A recombinant Leishmania chagasi antigen that stimulates cellular immune responses in infected mice
ME Wilson, BM Young, KP Andersen, JV Weinstock, A Metwali, KM Ali, JE Donelson
Infection and immunity 1995
Switch from a type 2 to a type 1 T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin 12 and Pentostam
GS Nabors, LC Afonso, JP Farrell, P Scott
Proceedings of the National Academy of Sciences 1995
Vaccination of vervet monkeys against cutaneous leishmaniosis using recombinant Leishmania ‘major surface glycoprotein’ (gp63)
JO Olobo, CO Anjili, MM Gicheru, PA Mbati, TM Kariuki, JI Githure, DK Koech, WR McMaster
Veterinary Parasitology 1995
Immunologic Response in Pregnancy: Its Role in Endocrine Disorders of Pregnancy and Influence on the Course of Maternal Autoimmune Diseases
B Formby
Endocrinology and metabolism clinics of North America 1995
Differing antibody IgG isotypes in the polar forms of leprosy and cutaneous leishmaniasis characterized by antigen-specific T cell anergy.
Ulrich M, Rodriguez V, Centeno M, Convit J
Clinical & Experimental Immunology 1995
Serum soluble markers in the evaluation of treatment in human visceral leishmaniasis.
Schriefer A, Barral A, Carvalho EM, Barral-Netto M
Clinical & Experimental Immunology 1995
Granulocyte-macrophage colony-stimulating factor in combination with pentavalent antimony for the treatment of visceral leishmaniasis
R Badaró, C Nascimento, JS Carvalho, F Badaró, D Russo, JL Ho, SG Reed, WD Johnson, TC Jones
European Journal of Clinical Microbiology & Infectious Diseases 1994
Cytokines in the treatment of leishmaniasis: From studies of immunopathology to patient therapy
JL Ho, R Badaro, D Hatzigeorgiou, SG Reed, WD Johnson
Biotherapy 1994
Dichotomy in the human CD4+T-cell response toLeishmaniaparasites
MI Kemp, JØ Kurtzhals, AR Kharazmi, TH Theander
APMIS 1994
Role of cytokines in determining T-lymphocyte function
A O'Garra, K Murphy
Current Opinion in Immunology 1994
Dichotomy of the human T cell response to Leishmania antigens. II. Absent or Th2-like response to gp63 and Thl-like response to lipophosphoglycan- associated protein in cells from cured visceral leishmaniasis patients
JA Kurtzhals, AS Hey, A Jardim, M Kemp, KU Schaefer, EO Odera, CB Christensen, JI Githure, RW Olafson, TG Theander, A Kharazmi
Clinical & Experimental Immunology 1994
The significance of blood levels of IgM, IgA, IgG and IgG subclasses in Sudanese visceral leishmaniasis patients
AM Elassad, SA Younis, M Siddig, J Grayson, E Petersen, HW Ghalib
Clinical & Experimental Immunology 1994
Evaluation of serum levels of soluble CD4, CD8 and β2-microglobulin in visceral human leishmaniasis
G Vitale, C Mocciaro, R Malta, G Gambino, A Spinelli, C Giordano, G Stassi, F Arcoleo, S Milano, E Cillari
Clinical & Experimental Immunology 1994
Natural autoantibodies, IgG antibodies to tetanus toxoid and CD5+ B cells in patients with Mediterranean visceral leishmaniasis
H Louzir, L Belal-Kachmi, A Sassi, D Laouini, R Ismail, K Dellagi
Clinical & Experimental Immunology 1994
Th1 and Th2 cell-associated cytokines in experimental visceral leishmaniasis
GD Miralles, MY Stoeckle, DF McDermott, FD Finkelman, HW Murray
Infection and immunity 1994
Evaluation of serum levels of soluble CD4, CD8 and beta 2-microglobulin in visceral human leishmaniasis
G Vitale, C Mocciaro, R Malta, G Gambino, A Spinelli, C Giordano, G Stassi, F Arcoleo, S Milano, E Cillari
Clinical & Experimental Immunology 1994
Dichotomy of the human T cell response to Leishmania antigens. II. Absent or Th2-like response to gp63 and Th1-like response to lipophosphoglycan-associated protein in cells from cured visceral leishmaniasis patients
JA Kurtzhals, AS Hey, A Jardim, M Kemp, KU Schaefer, EO Odera, CB Christensen, JI Githure, RW Olafson, TG Theander
Clinical & Experimental Immunology 1994
Antigens shared by Leishmania species and Trypanosoma cruzi: immunological comparison of the acidic ribosomal P0 proteins
YA Skeiky, DR Benson, M Elwasila, R Badaro, JM Burns, SG Reed
Infection and immunity 1994
Natural autoantibodies, IgG antibodies to tetanus toxoid and CD5+ B cells in patients with Mediterranean visceral leishmaniasis. The Leishmania Study Group
H Louzir, L Belal-Kacemi, A Sassi, D Laouini, RB Ismail, K Dellagi
Clinical & Experimental Immunology 1994
Parasitic Infections and the Immune System
F Kierszenbaum, MB Sztein
Parasitic Infections and the Immune System 1994
Interleukin 12 and the regulation of CD4+ T-cell subset responses during murine Leishmaniasis
FP Heinzel
Parasitology Today 1994
Aspects cliniques de la leishmaniose viscérale à l'ère du SIDA
A Bourgeade, Y Nosny, S Badiaga
Médecine et Maladies Infectieuses 1994
Treatment of atypical leishmaniasis with interferon ? resulting in progression of Kaposi's sarcoma in an AIDS patient
H Albrecht, , G Gross, B Berg, U Helmchen, H Mensing
The Clinical Investigator 1994
Cytokines in the Treatment of Infectious Diseases
BJ Kullberg, JW Meer
1994
The significance of blood levels of IgM, IgA, IgG and IgG subclasses in Sudanese visceral leishmaniasis patients.
Elassad AM, Younis SA, Siddig M, Grayson J, Petersen E, Ghalib HW
Clinical & Experimental Immunology 1994
In vivo cytokine profiles in patients with kala-azar. Marked elevation of both interleukin-10 and interferon-gamma
CL Karp, SH el-Safi, TA Wynn, MM Satti, AM Kordofani, FA Hashim, M Hag-Ali, FA Neva, TB Nutman, DL Sacks
Journal of Clinical Investigation 1993
Interleukin 10 production correlates with pathology in human Leishmania donovani infections
HW Ghalib, MR Piuvezam, YA Skeiky, M Siddig, FA Hashim, AM el-Hassan, DM Russo, SG Reed
Journal of Clinical Investigation 1993
Potential role for interleukin-10 in the immunosuppression associated with kala azar
BJ Holaday, MM Pompeu, S Jeronimo, MJ Texeira, AA Sousa, AW Vasconcelos, RD Pearson, JS Abrams, RM Locksley
Journal of Clinical Investigation 1993
T-cell and cytokine responses in leishmaniasis
SG Reed, P Scott
Current Opinion in Immunology 1993
Cytokines in the differentiation of Th1/Th2 CD4+ subsets in leishmaniasis
SL Reiner, RM Locksley
Journal of Cellular Biochemistry 1993
Leishmaniases of the New World: current concepts and implications for future research
G Grimaldi, RB Tesh
Clinical microbiology reviews 1993
Interleukin-4 but not gamma interferon production correlates with the severity of murine cutaneous leishmaniasis
L Morris, AB Troutt, KS McLeod, A Kelso, E Handman, T Aebischer
Infection and immunity 1993
Practical progress and new drugs for changing patterns of leishmaniasis
PL Olliaro, AD Bryceson
Parasitology Today 1993
Progress in Clinical Parasitology
T Sun
1993
Interferon-gamma in starch microparticles: nitric oxide-generating activity in vitro and antileishmanial effect in mice
L Degling, P Stjärnkvist, I Sjöholm
Pharmaceutical Research 1993
Short term treatment of visceral leishmaniasis of the old world with low dose interferon gamma and pentavalent antimony
J van Lunzen, J Schmitz, J Brazoska, S Flessenkämper, M Dietrich, P Kern
Infection 1993
The significance of serum soluble IL-2 receptor as a marker for active visceral leishmaniasis in Sicilian patients
G Vitale, G Reina, S Mansueto, R Malta, G Gambino, C Mocciaro, R D'agostino, M Dieli, E Cillari
Clinical & Experimental Immunology 1992
Cytokines and Ly-1 (B1) B Cells
A O'garra, M Howard
International Reviews of Immunology 1992
Chemotherapy and immunity in opportunistic parasitic infections in AIDS
A Zumla, SL Croft
Parasitology 1992
Histopathology of lymphoid organs in experimental leishmaniasis
CE Corbett, RA Paes, MD Laurenti, HF Júnior, MI Duarte
International Journal of Experimental Pathology 1992
Estado atual da leishmaniose cutânea difusa (LCD) no Estado do Maranhão: II. aspectos epidemiológicos, clínico-evolutivos
JM Costa, AC Saldanha, AC de Silva, AS Neto, CE Galvão, CM Silva, AR da Silva
Revista da Sociedade Brasileira de Medicina Tropical 1992
Cytokines in Hemopoiesis, Oncology, and AIDS II
M Freund, H Link, RE Schmidt, K Welte
1992
Cyclophosphamide affects the dynamics of granuloma formation in experimental visceral leishmaniasis
EB Corra, JM Cunha, MM Bunn-Moreno, ED Madeira
Zeitschrift für Parasitenkunde 1992
Intracellular Parasites
JL Avila, JR Harris
1992
Interferons 1992: How Much of the Promise Has Been Realised?
MA Volz, CH Kirkpatrick
Drugs 1992
The significance of serum soluble IL-2 receptor as a marker for active visceral leishmaniasis in Sicilian patients.
Vitale G, Reina G, Mansueto S, Malta R, Gambino G, Mocciaro C, D'Agostino R, Dieli M, Cillari E
Clinical & Experimental Immunology 1992
A Role for CD4+T-Cell Subsets Producing a Selective Pattern of Lymphokines in the Pathogenesis of Human Chronic Inflammatory and Allergic Diseases
G Peltz
Immunological Reviews 1991
Variations in susceptibility to Leishmania amazonensis infection in lines of mice selected for high or low immunoresponsiveness
R Falcoff, M Barral-Netto, C Stiffel, Y Bouthillier, A Barral, L Freitas, J Mevel, D Mouton
Parasite Immunology 1991
Evidence of subjects sensitized to Leishmania infantum on the French Mediterranean coast: differences in gamma interferon production between this population and visceral leishmaniasis patients
C Meller-Melloul, C Farnarier, S Dunan, B Faugere, J Franck, C Mary, P Bongrand, M Quilici, S Kaplanski
Parasite Immunology 1991
Production of interferon gamma, interleukin 2, interleukin 4, and interleukin 10 by CD4+ lymphocytes in vivo during healing and progressive murine leishmaniasis
FP Heinzel, MD Sadick, SS Mutha, RM Locksley
Proceedings of the National Academy of Sciences 1991
Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI
P Vieira, R Waal-Malefyt, MN Dang, KE Johnson, R Kastelein, DF Fiorentino, JE deVries, MG Roncarolo, TR Mosmann, KW Moore
Proceedings of the National Academy of Sciences 1991
Helper T-cell subsets in mouse leishmaniasis: induction, expansion and effector function
RM Locksley, P Scott
Immunology Today 1991
CD4+ T-cell subsets: regulation of differentiation and function
RL Coffman, TR Mosmann
Research in Immunology 1991
In vitro responses to Leishmania antigens by lymphocytes from patients with leishmaniasis or Chagas' disease
SG Reed, EM Carvalho, CH Sherbert, DP Sampaio, DM Russo, O Bacelar, DL Pihl, JM Scott, A Barral, KH Grabstein
Journal of Clinical Investigation 1990
Modulation of in vitro monocyte cytokine responses to Leishmania donovani. Interferon-gamma prevents parasite-induced inhibition of interleukin 1 production and primes monocytes to respond to Leishmania by producing both tumor necrosis factor-alpha and in
NE Reiner, W Ng, CB Wilson, WR McMaster, SK Burchett
Journal of Clinical Investigation 1990
Treatment of Visceral Leishmaniasis with Pentavalent Antimony and Interferon Gamma
R Badaro, E Falcoff, FS Badaro, EM Carvalho, D Pedral-Sampaio, A Barral, JS Carvalho, M Barral-Netto, M Brandely, L Silva, JC Bina, R Teixeira, R Falcoff, H Rocha, JL Ho, WD Johnson
New England Journal of Medicine 1990
Visceral leishmaniasis in patients infected with human immunodeficiency virus
C Montalban, JL Calleja, A Erice, F Laguna, B Clotet, D Podzamczer, J Cobo, J Mallolas, M Yebra, A Gallego
Journal of Infection 1990
Determinants of the immune response in visceral leishmaniasis: Evidence for predominance of endogenous interleukin 4 over interferon-γ production
K Zwingenberger, G Harms, C Pedrosa, S Omena, B Sandkamp, S Neifer
Clinical Immunology and Immunopathology 1990
Evasion strategies of Leishmania parasites
C Bogdan, M Röllinghoff, W Solbach
Parasitology Today 1990
Peptide Growth Factors and Their Receptors II
MB Sporn, AB Roberts
1990
Antigen-specific immunosuppression in visceral leishmaniasis is cell mediated
EM Carvalho, O Bacellar, A Barral, R Badaro, WD Johnson
Journal of Clinical Investigation 1989
Requirement for T cells and effect of lymphokines in successful chemotherapy for an intracellular infection. Experimental visceral leishmaniasis
HW Murray, MJ Oca, AM Granger, RD Schreiber
Journal of Clinical Investigation 1989
Profile of human T cell response to leishmanial antigens. Analysis by immunoblotting
PC Melby, FA Neva, DL Sacks
Journal of Clinical Investigation 1989
Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets
FP Heinzel, MD Sadick, BJ Holaday, RL Coffman, RM Locksley
Journal of Experimental Medicine 1989
Characterization of protective T cells in the acquired response to Leishmania donovani in genetically determined cure (H-2b) and noncure (H-2d) mouse strains
OM Ulczak, E Ghadirian, E Skamene, JM Blackwell, PA Kongshavn
Infection and immunity 1989
Comparison of T-cell responses in self-limiting versus progressive visceral Leishmania donovani infections in golden hamsters
C Gifawesen, JP Farrell
Infection and immunity 1989
Plasma lipoproteins in infantile visceral Leishmaniasis: deficiency of apolipoproteins A-I and A-II
ED Bekaert, R Kallel, ME Bouma, JF Lontie, A Mebazaa, CL Malmendier, M Ayrault-Jarrier
Clinica Chimica Acta 1989
Pharmacology of the Skin I
MW Greaves, S Shuster
1989
Immune Response in Chronic Schistosomiasis haematobium and mansoni
H Feldmeier, GA Gastl, U Poggensee, AA Daffalla, JA Nogueira-Queiroz, A Capron, HH Peter
Scandinavian Journal of Immunology 1988
Novel 17-kilodalton Leishmania antigen revealed by immunochemical studies of a purified glycoprotein fraction recognized by murine T lymphocytes
MM Rodrigues, MT Xavier, L Mendonça-Previato, MA Barcinski
Infection and immunity 1988
Kinetics of gamma interferon binding and induction of major histocompatibility complex class II mRNA in Leishmania-infected macrophages
NE Reiner, W Ng, T Ma, WR McMaster
Proceedings of the National Academy of Sciences 1988
Leishmania major: Analysis of lymphocyte and macrophage cellular phenotypes during infection of susceptible and resistant mice
FP Heinzel, MD Sadick, RM Locksley
Experimental Parasitology 1988
Monocytes and Macrophages
RB Johnston
New England Journal of Medicine 1988
Phagocytes and Disease
MS Klempner, B Styrt, J Ho
1988
Clinical Aspects of Interferons
M Revel
1988
A Newly Defined Property of Somatotropin: Priming of Macrophages for Production of Superoxide Anion
CK Edwards, SM Ghiasuddin, JM Schepper, LM Yunger, KW Kelley
Science 1988
Parasite-specific anergy in human filariasis. Insights after analysis of parasite antigen-driven lymphokine production
TB Nutman, V Kumaraswami, EA Ottesen
Journal of Clinical Investigation 1987
Kinetics of cell-mediated immunity developing during the course of Leishmania major infection in 'healer' and 'non-healer' mice: progressive impairment of response to and generation of interleukin-2
W Solbach, M Lohoff, H Streck, P Rohwer, M Röllinghoff
Immunology 1987
Cellular Immunity in the Joints of Patients with Rheumatoid Arthritis and Other Forms of Chronic Synovitis
GS Firestein, V Tsai, NJ Zvaifler
Rheumatic diseases clinics of North America 1987
Macrophage activation: Some questions
CF Nathan
Annales de l'Institut Pasteur / Immunologie 1986
Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques
E Jucker
1986
Tropical Pathology
H Spencer, AD Dayan, JB Gibson, RG Huntsman, MS Hutt, GC Jenkins, F Köberle, BG Maegraith, K Salfelder
1973

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