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Citations to this article

Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury
Mark R. Looney, … , Clifford A. Lowell, Michael A. Matthay
Mark R. Looney, … , Clifford A. Lowell, Michael A. Matthay
Published October 5, 2009
Citation Information: J Clin Invest. 2009;119(11):3450-3461. https://doi.org/10.1172/JCI38432.
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Research Article Pulmonology

Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury

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Abstract

Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-associated mortality in the US. Previously, we established an immune-mediated TRALI mouse model, wherein mice with cognate antigen were challenged with MHC class I mAb. In this study, when mice housed in a rodent, specific pathogen–free barrier room were challenged with MHC I mAb, there was significant protection from TRALI compared with nonbarrier mice. Priming mice with LPS restored lung injury with mAb challenge. Using TLR4-deficient bone marrow chimeras, the priming phenotype was restricted to animals with WT hematopoietic cells, and depletion of either neutrophils or platelets was protective. Both neutrophils and platelets were sequestered in the lungs of mice with TRALI, and retention of platelets was neutrophil dependent. Interestingly, treatment with aspirin prevented lung injury and mortality, but blocking the P selectin or CD11b/CD18 pathways did not. These data suggest a 2-step mechanism of TRALI: priming of hematopoietic cells, followed by vascular deposition of activated neutrophils and platelets that then mediate the severe lung injury. Furthermore, our data offer an explanation for the increased incidence of TRALI in patients with immune priming conditions, and we suggest what we believe to be a novel therapeutic approach.

Authors

Mark R. Looney, John X. Nguyen, Yongmei Hu, Jessica A. Van Ziffle, Clifford A. Lowell, Michael A. Matthay

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 Total
Citations: 1 7 5 18 11 24 12 12 12 17 23 18 13 17 16 8 1 215
Citation information
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Citations to this article in year 2024 (7)

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Proteomic profiling identifies SPP1 associated with rapidly progressive interstitial lung disease in anti-MDA5-positive dermatomyositis
Qiu Y, Feng X, Liu C, Shi Y, Xu L, You H, Wang L, Lv C, Wang F, Tan W
Arthritis Research & Therapy 2024
IgG hexamers initiate acute lung injury
Simon Cleary, Yurim Seo, Jennifer Tian, Nicholas Kwaan, David Bulkley, Arthur Bentlage, Gestur Vidarsson, Éric Boilard, Rolf Spirig, James Zimring, Mark Looney
Journal of Clinical Investigation 2024
IgG hexamers initiate acute lung injury
Cleary SJ, Seo Y, Tian JJ, Kwaan N, Bulkley DP, Bentlage AE, Vidarsson G, Boilard É, Spirig R, Zimring JC, Looney MR
2024
Guardians Turned Culprits: NETosis and Its Influence on Pulmonary Fibrosis Development.
Varughese A, Balnadupete A, Ramesh P, Prasad TSK, Nidha AB, Bhandary Y
Molecular Biotechnology 2024
Acute pulmonary injury in hematology patients supported with pathogen-reduced and conventional platelet components
Wheeler AP, Snyder EL, Refaai M, Cohn CS, Poisson J, Fontaine M, Sehl M, Nooka AK, Uhl L, Spinella PC, Fenelus M, Liles D, Coyle T, Becker J, Jeng M, Gehrie EA, Spencer BR, Young P, Johnson A, O\u2019Brien JJ, Schiller GJ, Roback JD, Malynn E, Jackups R, Avecilla ST, Liu K, Bentow S, Varrone J, Benjamin RJ, Corash LM
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Hydroxychloroquine attenuates sepsis-induced acute respiratory distress syndrome in rats
Ercan G, Saylav Bora E, Çınaroğlu OS, Karaali R, Erbas O
Turkish Journal of Trauma & Emergency Surgery 2024
Donor-Specific Blood Transfusion in Lung Transplantation
Jin X, Pirenne J, Vos R, Hooft C, Kaes J, Van Slambrouck J, Kortleven P, Vandervelde C, Beeckmans H, Kerckhof P, Carlon MS, Van Raemdonck D, Looney MR, Vanaudenaerde BM, Ceulemans LJ
Transplant International 2024

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